Merck

Biological Buffers

Image of light blue biological buffer solution in beaker with pipette.

It’s important to protect the integrity of your biomolecules and reagents by choosing the right biological buffer systems. We offer an extensive portfolio of biological buffers for a wide variety of applications, including cell culture buffers, PCR buffers, HEPES buffers, and assay buffers.

Key features of our advanced buffer systems:

  • High-purity solutions available in a wide range of grades
  • Multiple and user-friendly packaging options
  • Assured solution stability with pH control
  • No interference with biological processes
  • Add critical salts and nutrients to cells and tissues
  • Scalable from early research to commercial applications
  • Customized blending

Our advanced buffering systems can bring phenomenal stability to your cell culture, polymerase chain reaction (PCR), drug screening, bioprocessing, purification, and final formulation-based applications. All our products can be scaled from early research to commercial applications.


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Related Product Resources


Complete Workflow Solutions

We provide a comprehensive selection of high-quality biochemicals in a wide range of buffer grades and innovative, user-friendly packaging options. In addition to off-the-shelf products, we offer custom reagent manufacturing and customized blending.

Bioperformance Certified Buffers

Our superior BioPerformance Certified buffers are stringently tested and pre-qualified to expedite your bioprocessing workflows in critical life science applications, such as cell culture, molecular biology, and diagnostic manufacturing. This may include enzymatic assay of nuclease, protease, and phosphatase, cellular toxicity, or endotoxin and bioburden levels. Using a single high-quality buffer across multiple workflows ensures the reproducibility of your experiment.

pHast Pack™ Ready-to-Use Buffers

Trying to get the correct concentration and pH value in buffer preparations can be a tedious and time-consuming task. Our pHast Pack™ ready-to-use buffers are specially designed to simplify your work. Simply mix the precisely pre-weighed packets with distilled water for quick and reproducible results again and again. By saving time, effort and even shelf space, you can focus on more important areas of your research endeavors.

Need help making a buffer? Our buffer preparation calculator helps you to quickly calculate buffer molarity, mass, and volume.





Highlights


HEPES induces lysosomes and autophagy in culture cells
HEPES induces lysosomes & autophagy in culture cells - a call for action

Discover how HEPES may influence cell culture experiments and what to be aware of in data interpretation.



Webinar: Getting Your Buffers Right: How to Control the pH of Cell Culture Medium

This webinar will explain the principles of good practice in controlling the acid-base balance of culture media. It will highlight those combinations of buffers that can result in poor pH control, non-intuitive outcomes and erroneous inferences.

Buffer Selection Guide
Request your Buffer Selection Guide

The Biological Buffers Selection Guide can be a great reference piece to hang in your lab. Request your DIN A1 (23.4" x 33.1") poster.


pHast Pack ready-to-use buffers

Save time, effort, and shelf space with pHast Pack™ ready-to-use buffers. Our formulations are specially developed to simplify your work, and strictly tested to ensure exact concentrations and pH.