Skip to Content
Merck
HomeProductsPharma & Biopharma ManufacturingActive Pharmaceutical IngredientsAPI Processing Chemicals

API Processing Chemicals

Solid white substance solubilizing into fine powder / water

Solubility is an important aspect of solid and liquid drug formulation. Active pharmaceutical ingredient (API) solubility is critical for the success of the final dosage form and is necessary for the API’s absorption in the body and its therapeutic effect. As more and more APIs are poorly soluble, it’s crucial to take steps to enhance solubility either through API processing or formulation.

Go the API Processing Route

But why start optimizing API solubility during the late stage of formulation when you can truly enhance your API’s performance from the beginning?

Choose API processing to:

  • Improve API properties right from the start
  • Take advantage of established and proven technologies
  • Avoid the risk of dealing with a poorly water-soluble API in formulation development or the need to start API development from scratch

There are many techniques available for API processing based on your specific API’s characteristics and needs.

Request Information

Products

API processing | cocrystal formation (24)

API processing | salt formation (23)

API processing | nano-milling (15)

API processing | polymorph screening (14)

in vitro transcription (IVT) (1)

acids (19)

coatings (17)

stabilizers (15)

preservatives (12)

solvents (11)

binders (10)
Sort by Relevance
Showing 1-20 of 63
Change View
Showing 1-20 of 63
Ethanol
1.00986

Ethanol

absolute, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Hydrochloric acid
1.00314

Hydrochloric acid

37%, Emprove® ESSENTIAL, Ph. Eur., BP, JP, NF, fuming

TWEEN<SUP>®</SUP> 80 (Polysorbate)
8.17061

TWEEN® 80 (Polysorbate)

EMPROVE® ESSENTIAL, Ph. Eur., JP, NF

<SC>L</SC>-Histidine
1.04352

L-Histidine

EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP

Sodium dodecyl sulfate
8.17034

Sodium dodecyl sulfate

EMPROVE® ESSENTIAL, Ph. Eur.

Phenol
1.00201

Phenol

EMPROVE® ESSENTIAL, Ph. Eur., ChP, JP, USP

TWEEN<SUP>®</SUP> 20 (Polysorbate)
8.17072

TWEEN® 20 (Polysorbate)

EMPROVE® ESSENTIAL, Ph. Eur., JPE, NF

Methanol
1.06008

Methanol

EMPROVE® ESSENTIAL, Ph. Eur., BP, JPE, NF

Acetic acid
1.00056

Acetic acid

(glacial) 100%, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, E 260, USP

Benzoic acid
1.00130

Benzoic acid

powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, E 210

ortho-Phosphoric acid
1.00563

ortho-Phosphoric acid

85%, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPE, NF

Acetone
1.00013

Acetone

EMPROVE® ESSENTIAL, Ph. Eur., BP, JPE, NF

Sulfuric acid
1.00713

Sulfuric acid

95-98%, EMPROVE® ESSENTIAL, Ph. Eur., BP, JPE, NF

Chloroform
1.02431

Chloroform

EMPROVE® ESSENTIAL

Meglumine
1.06143

Meglumine

low in endotoxins, EMPROVE® API, Ph. Eur., ChP, JP, USP

Poloxamer 188
1.37112

Poloxamer 188

EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., ChP, NF

Acetic acid
1.37000

Acetic acid

100%, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

2-Propanol
1.00995

2-Propanol

EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP

Dichloromethane
1.06049

Dichloromethane

EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

Dimethyl sulfoxide
1.37117

Dimethyl sulfoxide

EMPROVE® EXPERT, Ph. Eur., ChP, USP

You have viewed 1-20 of 63 results
Page 1 of 4
Page 1 of 4
Two lab technicians in white lab coats are collaborating at a laboratory bench, one holding a clipboard and the other using a device. The background features various laboratory supplies and equipment, with a vibrant yellow and purple design framing the image.
The Emprove® Program
Comprehensive documentation to facilitate your qualification, risk assessment, and process optimization.
Learn More

High-quality Chemicals for Different API Processing Techniques

We provide a range of high-quality chemicals which target different API processing techniques. This way, you can focus on commercialization instead of on solubilization.

Explore our offering for:

The image depicts a cluster of purple and yellow hexagons on a teal background. Each yellow hexagon has a white plus and purple one has minus symbol at its center.
Salt Formation

High-quality chemical raw materials, such as acids, bases, and buffers, suitable for use as a counterion

The image features a geometric pattern on a teal background. There are multiple purple hexagons, each outlined in yellow. The hexagons are arranged in two rows, creating a honeycomb-like pattern.
Co-Crystal Formation

High-quality chemical raw materials suitable for use as a co-former

The image consists of two sets of distorted characters set against a turquoise background. The top set of characters is arranged in a rectangular grid format, while the bottom set of characters is more jumbled and less structured.
Polymorph Screening

Solvents addressing different polymorph screening techniques

The image shows a circle with a dark purple core, surrounded by yellow spike proteins resembling a sun or sea urchin. Small yellow arcs near the base of each spike add detail. The background is solid teal
Nano-Milling

Polymers and surfactants to support nano-crystal stability

Especially for salt and co-crystal formation, raw material quality is critical as the counterion and co-former are considered parts of the API by regulatory agencies. Whichever of these API processing methods you decide to use, we provide you with high-quality API processing chemicals which are part of the Emprove® Program. This provides 24/7 access to comprehensive documentation to support your management of regulatory- and quality-associated risks.

Our offering and service goes well beyond just supplying products for API processing. We offer easy access to an extensive portfolio of high-quality raw materials solutions that are easy to use, ensure product and patient safety, and meet your drug development and manufacturing needs. These products are designed to address pharmaceutical processes and manufacturing across all dosage forms.

Related Product Resources

Related Webinars

Slide 1 of 2
How to improve api solubility by salt and cocrystal formation

Webinar: How to Improve API Solubility by Salt and Cocrystal Formation

Learn when salt or cocrystal formation are your techniques of choice, and how to find the right coformers for your API.

Strategies and enabling technologies for enhancing api solubility

Webinar: Strategies and Enabling Technologies for Enhancing API Solubility

Learn about various strategies to optimize formulation of poorly soluble molecules depending on your API's properties.

Related Product Categories
Excipients for Your Liquid Application
Whether you are developing solutions, emulsions or suspensions – we provide high-quality pharmaceutical excipients for liquid formulations.
Solid Formulation: Excipients Used in Pharmaceutical Dosage Forms
Our comprehensive portfolio of high-quality raw materials and functionalized excipients helps you meet the challenges of solid formulation pharmaceutical manufacturing, backed by regulatory support for simplified supplier qualification, accelerated processes, and reduced total cost of ownership.
Related Applications
Liquid Formulation Strategies
Explore a variety of excipient solutions that address small molecule liquid formulation challenges and requirements.
Solid Formulation Strategies
Challenges such as API stability, release kinetics, and bioavailability have made the manufacturing of solid formulation pharmaceuticals more difficult, particularly given pressures to reduce costs and optimize process efficiency. Learn how new solutions and expert partnership can overcome these challenges.
Related Services
Emprove® Program – Two Decades of Easing Risk Management
Emprove® Program streamlines compliance with technical, regulatory, and supply information in Emprove® Dossiers, supporting risk assessment.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?