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Showing 1-30 of 3910 results for "34869" within Papers
Hae-Ryung Park et al.
Toxicology and applied pharmacology, 281(1), 67-77 (2014-10-12)
Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants, and BDE-47 is a prevalent PBDE congener detected in human tissues. Exposure to PBDEs has been linked to adverse pregnancy outcomes in humans. Although the underlying mechanisms of adverse birth outcomes
Yong Lu et al.
Nature communications, 5, 4229-4229 (2014-06-25)
Dendritic cell (DC)-based cancer immunotherapy is a promising method, but so far has demonstrated limited clinical benefits. Regulatory T cells (Tregs) represent a major obstacle to cancer immunotherapy approaches. Here we show that inhibiting p38 MAPK during DC differentiation enables
R Imbert et al.
Human reproduction (Oxford, England), 29(9), 1931-1940 (2014-06-25)
Do the benefits of ovarian tissue cryopreservation outweigh the risks for patients seeking to preserve fertility before gonadotoxic treatment in various indications? In >90% of the patients undergoing cryopreservation of ovarian tissue, oncological treatment was associated with a reduced ovarian
Xinmei Wang et al.
Biochimica et biophysica acta, 1853(1), 244-253 (2014-12-03)
A major obstacle to successful treatment of hepatocellular carcinoma (HCC) is its high resistance to cytotoxic chemotherapy due to overexpression of multidrug resistance genes. Activation of the AKT pathway is known to be involved in chemoresistance in HCC; however, the
Hercules Antônio da Silva-Souza et al.
Biochimica et biophysica acta, 1838(7), 1967-1977 (2014-04-20)
We have previously described that arachidonic acid (AA)-5-lipoxygenase (5-LO) metabolism inhibitors such as NDGA and MK886, inhibit cell death by apoptosis, but not by necrosis, induced by extracellular ATP (ATPe) binding to P2X7 receptors in macrophages. ATPe binding to P2X7
Lisa Yan et al.
The Prostate, 75(3), 280-291 (2014-11-18)
LIGHT, a ligand for lymphotoxin-β receptor (LTβR) and herpes virus entry mediator, is predominantly expressed on activated immune cells and LTβR signaling leads to the recruitment of lymphocytes. The interaction between LIGHT and LTβR has been previously shown to activate
Minjie Zhang et al.
Bone, 72, 92-100 (2014-12-03)
PGE2 exerts anabolic and catabolic effects on bone through the discrete actions of four prostanoid receptors (EP1-4). We have previously demonstrated that loss EP1 accelerates fracture repair by enhancing bone formation. In the present study we defined the role of
Balaram Thota et al.
Journal of neurosurgery, 121(2), 374-383 (2014-06-01)
Insulin-like growth factor binding proteins (IGFBPs) have been implicated in the pathogenesis of glioma. In a previous study the authors demonstrated that IGFBP-3 is a novel glioblastoma biomarker associated with poor survival. Since signal transducer and activator of transcription 1
Qingyi Tong et al.
Steroids, 96, 30-36 (2015-01-03)
Deltonin is a steroidal saponin which could suppress tumor growth through suppressing angiogenesis, but the mechanisms have not been directly elucidated yet. In the present study, we showed that deltonin inhibited the proliferation of primary cultured human umbilical vein endothelial
Sophie A George et al.
Psychopharmacology, 232(1), 47-56 (2014-06-01)
Post-traumatic stress disorder (PTSD) is a chronic, debilitating disorder. Only two pharmacological agents are approved for PTSD treatment, and they often do not address the full range of symptoms nor are they equally effective in all cases. Animal models of
Cédric Maerckx et al.
World journal of gastroenterology, 20(30), 10553-10563 (2014-08-19)
To test the ability of adult-derived human liver stem/progenitor cells (ADHLSC) from large scale cultures to conjugate bilirubin in vitro and in bilirubin conjugation deficient rat. ADHLSC from large scale cultures were tested for their phenotype and for their capacity
Yoko Yazaki-Sugiyama et al.
The European journal of neuroscience, 41(1), 97-108 (2014-10-30)
Genetically targeted approaches that permit acute and reversible manipulation of neuronal circuit activity have enabled an unprecedented understanding of how discrete neuronal circuits control animal behavior. Zebra finch singing behavior has emerged as an excellent model for studying neuronal circuit
Ge Liu et al.
Toxicology letters, 232(2), 384-392 (2014-12-03)
Dioxins are persistent environmental pollutants that cause multiple adverse health effects in humans, mainly through binding to the ligand-activated transcription factor, aryl hydrocarbon receptor (AhR). Genetic variation in AhR may modulate the susceptibility to dioxins. In this study, we aimed
Mei Yu So et al.
PloS one, 9(5), e96404-e96404 (2014-05-03)
Zearalenone (ZEA), a mycoestrogen produced by Fusarium fungal species, is mainly found in cereal crops such as maize, wheat and barley. Although ZEA has been reported to be present in air, little is known about the health risk or the
Aristotelis S Filippidis et al.
Journal of neurotrauma, 31(14), 1258-1267 (2014-03-19)
Brain swelling and increased intracranial pressure (ICP) following traumatic brain injury (TBI) contribute to poor outcome. Vasopressin-1a receptors (V1aR) and aquaporin-4 (AQP4) regulate water transport and brain edema formation, perhaps in part by modulating cation fluxes. After focal TBI, V1aR
Fanny Charbonnier-Beaupel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 96-111 (2015-01-09)
In Parkinson's disease, long-term dopamine replacement therapy is complicated by the appearance of L-DOPA-induced dyskinesia (LID). One major hypothesis is that LID results from an aberrant transcriptional program in striatal neurons induced by L-DOPA and triggered by the activation of
Takashi Nakamura et al.
Journal of cellular physiology, 230(4), 922-929 (2014-09-13)
Hedgehog (Hh) family members are involved in multiple cellular processes including proliferation, migration, differentiation, and cell fate determination. Recently, the novel Hh agonists Hh-Ag 1.3 and 1.7 were identified in a high-throughput screening of small molecule compounds that activate the
Chen Xuejun et al.
Archives of gynecology and obstetrics, 290(3), 525-532 (2014-04-04)
As water transporters, aquaporins (AQPs) are closely related to other membrane transporters, and water permeability in cell may contribute to chemosensitivity of tumor. To understand the correlation between AQPs and cisplatin (DDP) sensitivity to ovarian cancer cells, effects of DDP
Young H Lim et al.
ACS nano, 9(2), 1995-2008 (2015-01-27)
The development of well-defined polymeric nanoparticles (NPs) as delivery carriers for antimicrobials targeting human infectious diseases requires rational design of the polymer template, an efficient synthetic approach, and fundamental understanding of the developed NPs, e.g., drug loading/release, particle stability, and
Myeong-Hoon Kim et al.
Macromolecular bioscience, 14(7), 943-952 (2014-04-18)
Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to
Daniel Wehrung et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 962-972 (2014-08-17)
Recently, we reported the synthesis and biocompatibility of alkoxylphenacyl-based polycarbonates (APP); a promising new class of polymers that undergo photo-induced chain scission. In the current study, nanoparticles (NPs) were prepared from the APP polymer (APP-NPs) and loaded with doxorubicin (DOX)
Caroline Frizzell et al.
Toxicology letters, 229(2), 366-373 (2014-07-06)
Patulin (PAT) is a mycotoxin produced by various species of fungi, with Penicillium expansum being the most commonly occurring. Apples and apple products are the main sources of PAT contamination. This mycotoxin has been shown to induce toxic effects in
Ha-Young Park et al.
Bioscience, biotechnology, and biochemistry, 79(1), 130-137 (2014-09-02)
We investigated the effect of theaflavins (TFs) on membrane barrier of Caco-2 cells. For fluorescein-transport experiments, the apparent permeability (Papp) of fluorescein in Caco-2 cells pretreated with 20 μM TFs were significantly decreased compared with that in untreated cells. Although the
Shouju Wang et al.
Small (Weinheim an der Bergstrasse, Germany), 11(15), 1801-1810 (2015-01-08)
Shielding nanoparticles from nonspecific interactions with normal cells/tissues before they reach and after they leave tumors is crucial for the selective delivery of NPs into tumor cells. By utilizing the reversible protonation of weak electrolytic groups to pH changes, long-chain
Zhouwei Wu et al.
Journal of dermatological science, 75(1), 16-23 (2014-04-15)
Aquaporin 3 (AQP3) is the predominant aquaporin in the skin and is overexpressed in hyperplastic epidermal disorders. Upregulation of AQP3 contributes to keratinocyte proliferation and epidermal hyperplasia. Resveratrol, a natural polyphenol, has an anti-proliferative effect on normal human epidermal keratinocytes
Steven Knafo et al.
Journal of neurosurgery. Spine, 18(4), 378-381 (2013-02-26)
Subarachnoid-pleural fistula is a well-described complication after anterior surgery for thoracic disc herniation, but is difficult to treat by means of traditional chest and lumbar drains due to interference by positive ventilation pressures that may keep the fistula open and
Mayuri Sharma et al.
Journal of virology, 89(1), 523-534 (2014-10-24)
Herpesvirus nucleocapsids exit the host cell nucleus in an unusual process known as nuclear egress. The human cytomegalovirus (HCMV) UL97 protein kinase is required for efficient nuclear egress, which can be explained by its phosphorylation of the nuclear lamina component
Jin-A Lee et al.
Veterinary immunology and immunopathology, 161(3-4), 193-204 (2014-09-07)
Honeybee (Apis melifera) venom (HBV), which includes melittin and lipid-soluble ingredients (chrysin and pinocembrin), elicited increases in the CD4(+)/CD8(+) T lymphocyte ratio, relative mRNA expression levels of the T helper type 1 (Th 1) cytokines (interferon-γ and IL-12) and reinforced
Nicolas Ponroy et al.
Journal of medical virology, 87(1), 141-153 (2014-07-01)
Vasculoprotective and cholesterol-lowering properties are hallmarks of statins. Recently, statins have been found to exhibit antiviral activity. Little is known about the potential of statins against human cytomegalovirus (HCMV), a risk factor in the pathogenesis of atherosclerosis. In this study
Giovanna Di Emidio et al.
Human reproduction (Oxford, England), 29(9), 2006-2017 (2014-06-26)
Is SIRT1 involved in the oxidative stress (OS) response in mouse oocytes? SIRT1 plays a pivotal role in the adaptive response of mouse germinal vesicle (GV) oocytes to OS and promotes a signalling cascade leading to up-regulation of the MnSod
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