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613428

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Sebastian Meier
Analytical and bioanalytical chemistry, 406(30), 7763-7772 (2014-10-25)
Many functions of carbohydrates depend on the detection of short structural motifs, approximately up to hexasaccharide length, by receptors or catalysts. This study investigates the usefulness of state-of-the-art (1)H-(13)C nuclear-magnetic-resonance (NMR) spectroscopy for characterizing the diversity, abundance, and degradability of...
Wim F P M Van den Hof et al.
Toxicology, 324, 18-26 (2014-07-23)
The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better pre-clinical toxicity tests are needed. In order to bypass animal models for toxicity screening, we exposed primary mouse hepatocytes...
Liping Yang et al.
Biochimica et biophysica acta, 1844(9), 1684-1693 (2014-06-24)
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes...
Kazuyuki Nakajima et al.
Neuroscience letters, 591, 99-104 (2015-02-15)
We previously verified that newborn rat brain-derived microglia have the ability to uptake (14)C-glutamate (Glu) through glutamate transporter-1. A given amount of Glu incorporated into microglia was suspected to be metabolized to glutamine (Gln). However, the ability of microglia to...
Michael Wleklinski et al.
Physical chemistry chemical physics : PCCP, 17(28), 18364-18373 (2015-06-25)
Electrospray ionization of metal salt solutions followed by ambient heating transforms the resulting salt clusters into new species, primarily naked ionic metal clusters. The experiment is done by passing the clusters through a heated coiled loop outside the mass spectrometer...
Luke A Clifton et al.
Methods in molecular biology (Clifton, N.J.), 974, 119-150 (2013-02-14)
Studying the structure of protein-lipid complexes, be they in vesicles, planar bilayers, monolayers, or nanodiscs, poses two particular challenges. Firstly such complexes are often dynamic. Secondly we need to resolve the lipid and protein structures within the complex. Neutron scattering...
Arianna Bertolani et al.
Nature communications, 6, 7574-7574 (2015-07-01)
Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable...
Wei Liu et al.
Journal of food science, 80(11), C2413-C2419 (2015-09-30)
The dynamic hydrolysis of tetrasodium pyrophosphate (TSPP), sodium tripolyphosphate (STPP) and polyphosphate compound, which was catalyzed by purified pyrophosphatase (PPase) and myosin- tripolyphosphatase (TPPase) from the silver carp dorsal muscle, was studied using (31) P NMR spectroscopy. In the PPase...
Sebastian Trousil et al.
Cancer research, 74(23), 6867-6877 (2014-10-01)
Metabolic rearrangements subsequent to malignant transformation are not well characterized in endometrial cancer. Identification of altered metabolites could facilitate imaging-guided diagnosis, treatment surveillance, and help to identify new therapeutic options. Here, we used high-resolution magic angle spinning magnetic resonance mass...
Zhi Liu et al.
PloS one, 10(9), e0137124-e0137124 (2015-09-05)
The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all base...
Jose C Paz et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17116-17121 (2014-11-19)
In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions in catecholamine signaling, where it contributes...
Arpana Dutta et al.
Biochemistry, 53(46), 7160-7169 (2014-10-01)
Rhodopsin is a model system for understanding membrane protein folding. Recently, conditions that allow maximally denaturing rhodopsin without causing aggregation have been determined, opening the door to the first structural characterization of denatured states of rhodopsin by nuclear magnetic resonance...
Rachel R Schendel et al.
Carbohydrate research, 407, 16-25 (2015-02-24)
In comparison to the annual grain crops dominating current agricultural production, perennial grain species require fewer chemical and energy inputs and improve soil health and erosion control. The possibility for producing sustainable grain harvests from marginal land areas is motivating...
Barry W Hyland et al.
Clinical oral investigations, 19(6), 1395-1404 (2014-11-09)
This study aimed to develop and characterise a new three-component dental whitening formulation which is as effective as the currently used carbamide peroxide but at significantly lower hydrogen peroxide concentrations. The new formulation (Carbamide Plus) was prepared containing hydrogen peroxide...
Jeeyoun Jung et al.
PLoS neglected tropical diseases, 9(1), e3427-e3427 (2015-01-09)
Tsutsugamushi disease is an infectious disease transmitted to humans through the bite of the Orientia tsutsugamushi-infected chigger mite; however, host-pathogen interactions and the precise mechanisms of damage in O. tsutsugamushi infections have not been fully elucidated. Here, we analyzed the...
Daniela Giordano et al.
The FEBS journal, 282(15), 2948-2965 (2015-06-05)
Truncated hemoglobins build one of the three branches of the globin protein superfamily. They display a characteristic two-on-two α-helical sandwich fold and are clustered into three groups (I, II and III) based on distinct structural features. Truncated hemoglobins are present...
N Ravenscroft et al.
Carbohydrate research, 404, 108-116 (2015-02-11)
Salmonella paratyphi A is increasingly recognized as a common cause of enteric fever cases and there are no licensed vaccines against this infection. Antibodies directed against the O-polysaccharide of the lipopolysaccharide of Salmonella are protective and conjugation of the O-polysaccharide...
Zdeněk Sofer et al.
Nanoscale, 7(23), 10535-10543 (2015-05-28)
Graphane is one of the most intensively studied derivatives of graphene. Here we demonstrate the evaluation of exact degree of graphene hydrogenation using the Clemmensen reduction reaction and deuterium labeling. The Clemmensen reduction reaction is based on application of zinc...
Nancy Witowski et al.
PloS one, 10(4), e0124467-e0124467 (2015-04-16)
Hemorrhagic shock accompanied by injury represents a major physiologic stress. Fasted animals are often used to study hemorrhagic shock (with injury). A fasted state is not guaranteed in the general human population. The objective of this study was to determine...
Matthew W Waugh et al.
Biochemistry, 53(34), 5537-5543 (2014-08-22)
The reaction catalyzed by cyanobacterial aldehyde deformylating oxygenase is of interest both because of its potential application to the production of biofuels and because of the highly unusual nature of the deformylation reaction it catalyzes. Whereas the proton in the...
Ning Li et al.
Journal of proteome research, 14(3), 1566-1573 (2015-02-12)
Prostaglandin E2 receptor 4 (EP4) is one of the receptors for prostaglandin E2 and plays important roles in various biological functions. EP4 antagonists have been used as anti-inflammatory drugs. To investigate the effects of an EP4 antagonist (L-161982) on the...
Barbara R Evans et al.
Planta, 242(1), 215-222 (2015-04-22)
The bioenergy crop switchgrass was grown hydroponically from tiller cuttings in 50 % D 2 O to obtain biomass with 34 % deuterium substitution and physicochemical properties similar to those of H 2 O-grown switchgrass controls. Deuterium enrichment of biological...
Aurore Flandrin et al.
Journal of mass spectrometry : JMS, 50(12), 1358-1366 (2015-12-05)
Ascorbate is as a potent antioxidant in vivo protecting the organism against oxidative stress. In this process, ascorbate is oxidized in two steps to dehydroascorbate (DHA), which if not efficiently reduced back to ascorbate decomposes irreversibly to a complex mixture...
Jutta K H Skau et al.
The American journal of clinical nutrition, 101(4), 742-751 (2015-04-04)
Poor nutritional quality of complementary foods often limits growth. Animal source foods, such as milk or meat, are often unaffordable. Local affordable alternatives are needed. We evaluate the efficacy of 2 newly developed, rice-based complementary food products: WinFood (WF) with...
Eric Bonneau et al.
RNA (New York, N.Y.), 21(9), 1621-1632 (2015-07-01)
As part of an effort to structurally characterize the complete Neurospora VS ribozyme, NMR solution structures of several subdomains have been previously determined, including the internal loops of domains I and VI, the I/V kissing-loop interaction and the III-IV-V junction....
Sandra J Veen et al.
Physical review letters, 109(24), 248302-248302 (2013-02-02)
By using the critical Casimir force, we study the attractive strength dependent aggregation of colloids with and without gravity by means of near field scattering. Significant differences were seen between microgravity and ground experiments, both in the structure of the...
Ge Wang et al.
Soft matter, 11(26), 5253-5264 (2015-06-09)
The temperature-induced phase transition behaviors of a thermoresponsive ionic liquid (tributylhexylphosphonium 3-sulfopropylmethacrylate, [P4,4,4,6][MC3S]) and its polymer (poly-tributylhexylphosphonium 3-sulfopropylmethacrylate, P[P4,4,4,6][MC3S]) have been investigated using DSC, optical microscopy, temperature-variable (1)H NMR, and FT-IR in combination with two-dimensional analysis methods, including perturbation correlation...
Anna A DePaoli-Roach et al.
The Journal of biological chemistry, 290(2), 841-850 (2014-11-25)
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate per 500-2000 glucose residues depending on the source. The function...
Yunbin Xiao et al.
International journal of nanomedicine, 10, 1155-1172 (2015-02-25)
Magnetic resonance imaging (MRI) contrast agents based on chitosan derivatives have great potential for diagnosing diseases. However, stable tumor-targeted MRI contrast agents using micelles prepared from high molecular weight chitosan derivatives are seldom reported. In this study, we developed a...
Noreen Yaqoob et al.
Toxicology, 323, 70-77 (2014-06-14)
Trichloroethylene (TCE) is widely used as a cleaning and decreasing agent and has been shown to cause liver tumours in rodents and a small incidence of renal tubule tumours in male rats. The basis for the renal tubule injury is...
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