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Anna E Rapp et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1235-1241 (2015-04-17)
Abatement of fracture-related pain is important in patient welfare. However, the frequently used non-steroidal anti-inflammatory drugs are considered to impair fracture healing through blockade of cyclooxygenase-2. An alternative for fracture-related pain treatment may be blockade of nerve growth factor (NGF)/neurotrophic
Li-na Sun et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 1079-1088 (2014-12-03)
Epithelial-mesenchymal transition (EMT) is recognized to play a key role in diabetic nephropathy (DN). Curcumin, the main active component of turmeric extracted from the roots of the Curcuma longa plant, has been reported for its anti-fibrotic effects in kidney fibrosis. The
Weijun Xuan et al.
Journal of biophotonics, 8(6), 502-511 (2014-09-10)
Transcranial low-level laser (light) therapy (LLLT) is a new non-invasive approach to treating a range of brain disorders including traumatic brain injury (TBI). We (and others) have shown that applying near-infrared light to the head of animals that have suffered
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 15(3), 573-578 (2005-01-25)
A detailed inhibition study of five carbonic anhydrase (CA, EC 4.2.1.1) isozymes with carboxylates including aliphatic (formate, acetate), dicarboxylic (oxalate, malonate), hydroxy/keto acids (l-lactate, l-malate, pyruvate), tricarboxylic (citrate), or aromatic (benzoate, tetrafluorobenzoate) representatives, some of which are important intermediates in
Tong-Song Wang et al.
Biology open, 4(7), 893-902 (2015-05-24)
The prevalence of diabetes is increasing worldwide with the trend of patients being young and creating a significant burden on health systems, including reproductive problems, but the effects of diabetes on embryo implantation are still poorly understood. Our study was
Sebastian Hafner et al.
Shock (Augusta, Ga.), 43(2), 140-147 (2014-12-20)
Blunt chest trauma causes pulmonary and systemic inflammation. It is still a matter of debate whether the long-term course of this inflammatory response is associated with persistent impairment of lung function. We hypothesized that an increase of inflammatory biomarkers may
Franziska Bollmann et al.
PloS one, 10(6), e0130401-e0130401 (2015-06-16)
Patients suffering from chronic inflammatory diseases have an increased mortality risk resulting from cardiovascular disorders due to enhanced atherosclerotic and thrombotic events. Until now, it is not completely understood in which way an abnormal expression of pro-inflammatory mediators contributes to
Seokyung Kang et al.
ACS nano, 9(10), 9678-9690 (2015-09-09)
Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal
Janet L Huebner et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(9), 2440-2449 (2014-06-10)
To evaluate joint tissue remodeling using the urinary collagen biomarkers urinary α-C-telopeptide of type I collagen (α-CTX) and urinary C-telopeptide of type II collagen (CTX-II) and to determine the association of these biomarkers with osteoarthritis (OA) severity, progression, and localized
Devin R McCormack et al.
Biomedical optics express, 5(7), 2247-2261 (2014-07-30)
HER2-amplified (HER2 + ) breast cancers are treated with the anti-HER2 monoclonal antibody trastuzumab. Although trastuzumab reduces production of the angiogenic factor VEGF in HER2 + tumors, the acute and sustained effects of trastuzumab on the tumor vasculature are not
Linlin Zhu et al.
Placenta, 36(10), 1148-1152 (2015-08-26)
Placental dysfunction and increased inflammation are believed to underlie the pathogenesis of severe preeclampsia (PE). High-mobility group box 1 (HMGB1), a recently identified inflammatory cytokine, has been known to contribute to the development of inflammatory responses in PE. This study
Gamze Karaca et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(4), G325-G334 (2014-12-20)
TNF-like weak inducer of apoptosis (TWEAK) is a growth factor for bipotent liver progenitors that express its receptor, fibroblast growth factor-inducible 14 (Fn14), a TNF receptor superfamily member. Accumulation of Fn14(+) progenitors occurs in severe acute alcoholic steatohepatitis (ASH) and
Dae Song Jang et al.
Journal of biomolecular screening, 20(2), 202-211 (2014-10-19)
Deoxyribonuclease I (DNase I), the most active and abundant apoptotic endonuclease in mammals, is known to mediate toxic, hypoxic, and radiation injuries to the cell. Neither inhibitors of DNase I nor high-throughput methods for screening of high-volume chemical libraries in
Tina C Roeske et al.
PloS one, 9(11), e111722-e111722 (2014-11-14)
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays
Arkady Uryash et al.
PloS one, 10(7), e0131392-e0131392 (2015-07-03)
The recognition that oxidative stress is a major component of several chronic diseases has engendered numerous trials of antioxidant therapies with minimal or no direct benefits. Nanomolar quantities of nitric oxide released into the circulation by pharmacologic stimulation of eNOS
Ahmed I Mahmoud et al.
Developmental cell, 34(4), 387-399 (2015-08-11)
Some organisms, such as adult zebrafish and newborn mice, have the capacity to regenerate heart tissue following injury. Unraveling the mechanisms of heart regeneration is fundamental to understanding why regeneration fails in adult humans. Numerous studies have revealed that nerves
A Barreca et al.
Blood cancer journal, 4, e249-e249 (2014-10-11)
Most follicular lymphomas (FLs) are genetically defined by the t(14;18)(q32;q21) translocation that juxtaposes the BCL2 gene to the immunoglobulin heavy chain (IgH) 3' regulatory regions (IgH-3'RRs). Despite this recurrent translocation, FL cases are heterogeneous in terms of intratumoral clonal diversity
Matthew S Kelker et al.
PloS one, 9(11), e112555-e112555 (2014-11-13)
Bacillus thuringiensis strains are well known for the production of insecticidal proteins upon sporulation and these proteins are deposited in parasporal crystalline inclusions. The majority of these insect-specific toxins exhibit three domains in the mature toxin sequence. However, other Cry
Mathieu André et al.
Organic & biomolecular chemistry, 13(2), 388-397 (2014-11-05)
In the development of our melanoma-selective delivery approach, three preselected conjugates of 5-iodo-2'-deoxyuridine (IUdR) to the ICF01012 melanoma-carrier were radiolabelled with iodine-125, and their in vivo distribution profile was determined. A radioiodination method for the conjugate 1a and its PEGylated
Hong Huang et al.
Journal of dermatological science, 79(3), 241-251 (2015-06-21)
Wound healing is impaired in diabetes mellitus. The underlying mechanism involved in this process is still unknown. The Akt/mTOR signaling pathway plays a crucial role in the pathogenesis of diabetes. we investigated the role of the Akt/mTOR pathway in diabetic
Zhongping Xu et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 6133-6143 (2015-05-06)
Immune responses to HLA and development of anti-donor HLA (DSA) were shown to play a role in chronic rejection following transplantation. We hypothesized that Abs to MHC change microRNAs (miRNAs), leading to chronic lung allograft rejection. Microarray analysis was performed
Feifeng Jing et al.
International journal of oncology, 46(4), 1582-1588 (2015-01-28)
CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic
Ryan L O'Hare Doig et al.
Experimental neurology, 261, 136-146 (2014-06-17)
Secondary degeneration contributes substantially to structural and functional deficits following traumatic injury to the CNS. While it has been proposed that oxidative stress is a feature of secondary degeneration, contributing reactive species and resultant oxidized products have not been clearly
Kai-liang Zhou et al.
Scientific reports, 5, 17130-17130 (2015-11-26)
In this study we examined the relationship between autophagy and apoptosis in diabetic rats after spinal cord injury (SCI), also we determined the role of autophagy in diabetes-aggravated neurological injury in vivo and in vitro. Our results showed that diabetes
Xiaoqing Yan et al.
Journal of cellular and molecular medicine, 19(7), 1557-1568 (2015-04-01)
Fibroblast growth factor 21 (FGF21) plays an important role in energy homoeostasis. The unaddressed question of FGF21's effect on the development and progression of diabetic cardiomyopathy (DCM) is investigated here with FGF21 knockout (FGF21KO) diabetic mice. Type 1 diabetes was
B J Oh et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(6), 1543-1554 (2015-04-14)
The spheroid culture method is an effective strategy for ex vivo expansion of an autologous therapeutic cell population. We investigated if cotransplantation of bone marrow-derived spheroids (BM-spheroid) formed using 3D culture of BM-derived mononuclear cells (BM-MNCs) could improve the posttransplant
Trisodium citrate-assisted synthesis of highly water-dispersible and superparamagnetic mesoporous Fe3O4 hollow microspheres via solvothermal process
Jiang X, et al.
Journal of alloys and compounds, 636, 34-39 (2015)
A Stančić et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(10), 1432-1445 (2015-08-01)
G protein-coupled receptor 55 (GPR55) is a lysophospholipid receptor responsive to certain cannabinoids. The role of GPR55 in inflammatory processes of the gut is largely unknown. Using the recently characterized GPR55 inhibitor CID16020046, we determined the role of GPR55 in experimental
Qiang Wang et al.
OncoTargets and therapy, 8, 1971-1977 (2015-08-12)
Claudins are found in junctional complexes mediating cell adhesion and are involved in the attachment of tight junctions to the underlying cytoskeleton. Abnormal claudin-6 expression has been observed for a variety of malignant solid tumors, but the expression of claudin-6
Marjan Gharagozloo et al.
Journal of neuroinflammation, 12, 198-198 (2015-11-02)
Multiple sclerosis (MS) is an organ-specific autoimmune disease resulting in demyelinating plaques throughout the central nervous system. In MS, the exact role of microglia remains unknown. On one hand, they can present antigens, skew T cell responses, and upregulate the
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