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Yang Zhou et al.
Vaccine, 33(19), 2254-2260 (2015-03-31)
Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen that can also cause epidemics of life-threatening infections in humans. Surface proteins of pathogens play a critical role in the interaction with host system or environment, as they
Haruko Watanabe-Takano et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(22), E2291-E2300 (2014-05-21)
Alveolar formation is coupled to the spatiotemporally regulated differentiation of alveolar myofibroblasts (AMYFs), which contribute to the morphological changes of interalveolar walls. Although the Ras-ERK signaling pathway is one of the key regulators for alveolar formation in developing lungs, the
Panojot Bifsha et al.
PLoS genetics, 10(12), e1004863-e1004863 (2014-12-17)
Parkinson disease (PD) is characterized by the preferential, but poorly understood, vulnerability to degeneration of midbrain dopaminergic (mDA) neurons in the ventral substantia nigra compacta (vSNc). These sensitive mDA neurons express Pitx3, a transcription factor that is critical for their
Elizabeth G Demicco et al.
Human pathology, 46(7), 1015-1026 (2015-05-16)
This study aimed to evaluate expression of receptor tyrosine kinases, their ligands, and mutational status in solitary fibrous tumors, with correlation to histopathologic variants, tumor stage, and aggressive behavior. Immunohistochemical staining for PDGFα; PDGFβ; PDGFR-α; PDGFR-β; IGF1R; EGFR; VEGF; IGF2;
Ina Maria Kacsó et al.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 56(1), 93-99 (2015-04-01)
Toll-like receptor 4 (TLR4) signaling is involved in various acute and chronic renal lesions and contributes to inflammation and fibrosis in several organs; the latter are important determinants to the progression of chronic kidney disease (CKD). We aimed to assess
Xiao-Liang Zhang et al.
Endocrinology, 155(12), 4939-4950 (2014-09-05)
Increasing evidence suggests the heterogeneity of macrophage phenotype and function ultimately determines the outcome of diabetic nephropathy (DN). This study aimed to investigate the effects of vitamin D on macrophage M1/M2 phenotype and its role in preventing podocyte impairment in
T Rich et al.
Veterinary pathology, 52(4), 621-630 (2014-08-28)
Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that
Dual fluorescence detection of protein and RNA in Drosophila tissues
Toledano H, et al.
Nature Protocols, 7(10), 1808-1808 (2012)
R Allemang-Grand et al.
Neurobiology of aging, 36(2), 638-647 (2014-10-15)
Murine models of Alzheimer's disease (AD) have been used to draw associations between atrophy of neural tissue and underlying pathology. In this study, the early-onset TgCRND8 mouse model of AD and littermate controls were scanned longitudinally with in vivo manganese-enhanced
Marina Rolo Pinheiro da Rosa et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11107-11120 (2014-08-08)
Ameloblastoma is an odontogenic tumor characterized by local invasiveness and frequent recurrence. The surrounding stroma, composed of different cell types and extracellular matrix (ECM), may influence ameloblastoma invasive behavior. Furthermore, tumor and stromal cells secrete matrix metalloproteases (MMPs), which, in
Eun Young Kim et al.
Biochimica et biophysica acta, 1852(7), 1388-1399 (2015-04-11)
Sumoylation is a posttranslational modification that regulates a wide spectrum of cellular activities. Cardiomyopathy is the leading cause of heart failure. Whether sumoylation, particularly SUMO-2/3 conjugation, is involved in cardiomyopathy has not been investigated. We report here that SUMO-2/3 conjugation
Agnieszka Jazwa et al.
Vascular pharmacology, 71, 127-138 (2015-04-15)
Heme oxygenase-1 (HO-1) mitigates cellular injury by antioxidant, anti-apoptotic, anti-inflammatory and proangiogenic effects. Vascular endothelial growth factor (VEGF) is a critical regulator of blood vessel growth. Their coordinated action was analyzed in a model of femoral artery ligation (FAL) in
Alex Cazes et al.
Oncotarget, 5(9), 2688-2702 (2014-05-09)
Activating mutations of the ALK (Anaplastic lymphoma Kinase) gene have been identified in sporadic and familial cases of neuroblastoma, a cancer of early childhood arising from the sympathetic nervous system (SNS). To decipher ALK function in neuroblastoma predisposition and oncogenesis
Silvio Tundo et al.
Plant science : an international journal of experimental plant biology, 240, 161-169 (2015-10-18)
To shed light on the role of Xylanase Inhibitors (XIs) during Fusarium graminearum infection, we first demonstrated that three out of four F. graminearum xylanases, in addition to their xylan degrading activity, have also the capacity to cause host cell
Dilip Devineni et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 332-341 (2014-05-27)
Lyophilized formulations of keratinocyte growth factor-2 (KGF-2) were prepared with a range of disaccharide (sucrose or trehalose) and hydroxyethyl starch (HES) mass ratios. Protein degradation was assessed as a function of time of storage of the dried formulations at 40
Robert N Schuck et al.
PloS one, 9(10), e110162-e110162 (2014-10-14)
Fatty liver disease is an emerging public health problem without effective therapies, and chronic hepatic inflammation is a key pathologic mediator in its progression. Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have potent
Citrate anticoagulation for continuous renal replacement therapy (CRRT) in patients with acute kidney injury admitted to the intensive care unit
Davenport Aand Tolwani A
NDT Plus, 2(6), 439-447 (2009)
Xinying Wang et al.
JPEN. Journal of parenteral and enteral nutrition, 39(6), 688-697 (2014-05-20)
Patients receiving parenteral nutrition (PN) are at increased risk of infectious complications compared with enteral feeding, which is in part explained by impaired mucosal immune function during PN. Adding glutamine (GLN) to PN has improved outcome in some clinical patient
Yanan Li et al.
Mikrochimica acta, 187(2), 119-119 (2020-01-14)
A colorimetric microplate assay for determination of Staphylococcus aureus DNA is described. Linear padlock probes were designed to recognize target sequences. After DNA binding, the linear padlock probes were circularized by ligation and then hybridize with biotin-labeled capture probes. Biotin-labeled capture
Sabrina Lechner et al.
International journal of medical microbiology : IJMM, 304(8), 931-940 (2014-07-02)
Treatment of stationary growth phase Staphylococcus aureus SA113 with 100-fold of the MIC of the lipopeptide antibiotic daptomycin leaves alive a small fraction of drug tolerant albeit genetically susceptible bacteria. This study shows that cells of this subpopulation exhibit active
Jamie Merves et al.
PloS one, 10(2), e0114831-e0114831 (2015-02-28)
Eosinophilic Esophagitis (EoE) is a chronic allergic disorder, whose pathobiology is incompletely understood. Histamine-producing cells including mast cells and basophils have been implicated in EoE. However, very little is currently known about the role of histamine and histamine receptor (HR)
Alena Evers et al.
Transplant international : official journal of the European Society for Organ Transplantation, 28(1), 95-107 (2014-09-03)
Acute rejection and respiratory infections are major risk factors for chronic lung allograft dysfunction (CLAD) after lung transplantation. To shed light on the enigmatic etiology of CLAD, we test the following hypotheses using a new experimental model: (i) Alloimmune-independent pulmonary
Arvind Pandey et al.
Nanomaterials (Basel, Switzerland), 10(9) (2020-09-03)
It has been suggested that particle size plays an important role in determining the genotoxicity of gold nanoparticles (GNPs). The purpose of this study was to compare the potential radio-sensitization effects of two different sized GNPs (3.9 and 37.4 nm)
Yanzhong Yang et al.
Nature communications, 6, 6428-6428 (2015-03-05)
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-binding partners, linking PRMT9 to U2 snRNP maturation.
Yarong Guo et al.
Hepatology international, 9(1), 130-141 (2015-03-20)
Previously, we suggested that IGFBPrP1 played a major role in hepatic stellate cell (HSC) activation, yet the molecular mechanism of IGFBPrP1 in hepatic fibrosis is unclear. The ERK pathway is involved in activation of HSCs. This study investigated the involvement
Xiaozhou Yu et al.
Cancer genetics, 208(3), 76-84 (2015-03-17)
Recent findings have suggested that microRNAs may be involved in the regulation of metastasis in malignant cancers such as non-small cell lung cancer (NSCLC). This study aimed to determine the relationship between expression of miR-125b and matrix metalloproteinase 13 (encoded
C G Mobley et al.
Journal of dental research, 94(8), 1128-1134 (2015-05-23)
The Trps1 transcription factor is highly expressed in dental mesenchyme and preodontoblasts, while in mature, secretory odontoblasts, it is expressed at low levels. Previously, we have shown that high Trps1 levels in mature odontoblasts impair their function in vitro and
Joon Ha Lee et al.
BMB reports, 48(6), 324-329 (2014-07-23)
CopA3 is a homodimeric α-helical peptide derived from coprisin which is a defensin-like antimicrobial peptide that was identified from the dung beetle, Copris tripartitus. CopA3 has been reported to have anticancer activity against leukemia cancer cells. In the present study
Maria Samalidou et al.
Experimental biology and medicine (Maywood, N.J.), 240(12), 1728-1734 (2015-06-17)
Liposomal amphotericin B, voriconazole, and caspofungin are currently used for systemic and severe fungal infections. Patients with malignant diseases are treated with granulocyte-colony stimulating factor (G-CSF) for the recovery of granulocytes after chemotherapy or hematopoietic cell (HC) transplantation. Since they
Navdha Mittal et al.
PloS one, 9(10), e110410-e110410 (2014-10-24)
Resistance to progestin treatment is a major hurdle in the treatment of advanced and reoccurring endometrial cancer. Fenretinide is a synthetic retinoid that has been evaluated in clinical trials as a cancer therapeutic and chemo-preventive agent. Fenretinide has been established
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