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Staudinger Ligation
The reaction between an azide and a phosphine forming an aza-ylide was discovered almost a century ago by Nobel Prize laureate Herrmann Staudinger.
Biologic APIs and Conjugation Experts – SAFC - St. Louis
SAFC’s St. Louis, Missouri (USA) campus is a key center of manufacturing excellence in cGMP biologics, with over 25 years experience in plant- and animal-based therapeutic protein extraction and purification, bio-conjugation, excipients and adjuvants manufacturing.
Uronium and Guanidinium Salts for Peptide Coupling
The special need of SPPS for rapid and highly efficient coupling reagents led to the development of several new reagents starting from BOP (Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate).
Traceless Staudinger Ligation
Based on the same working principle as the nontraceless Staudinger Ligation the auxiliary phosphine reagent can be cleaved from the product after the ligation is completed leaving a native amide bond. Thus, the total chemical synthesis of proteins and glycopeptides
Fluorescent Labeling of Peptides
Fluorescent Labeling of Peptides
Safe Manufacture of Antibody Drug Conjugates
Although antibody-drug conjugates show promise in the development of effective cancer therapies, there are still a variety of challenges involved in enabling the safe manufacture of these hazardous drugs.
Polybrene® Technical Bulletin
Polybrene® is a well-known anti-heparin agent. Also known as 1,5-dimethyl-1,5-diazaundecamethylene polymethobromide and hexadimethrine bromide, this positively charged polymer produces non-specific red blood cell agglutination by neutralizing the red blood cell net negative charge.
Triazolylphenylglyoxal Reagents: Arginine-Directed Bioconjugation
Chemical ligation strategies are widely utilized for the modification of biological macromolecules in biotechnology and medicine, and in for the development of functional materials. In particular, reagents that can modify the surface of proteins, typically through reactive side chains, have
Guanylation of Amines by Bis(tert-butoxycarbonyl)thiopseudourea, Polymer-Bound
1 Introduction of a guanidinyl group can be achieved by the reaction of substituted amines with various guanylation reagents.2,3,4 One such guanylating reagent is bis(tert-butoxycarbonyl)thiopseudourea, polymer-bound.
Copper-Free Click Chemistry
Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.
Staudinger Ligation
Originally reported by Staudinger and Meyer, azides react readily with triarylphosphines to form the corresponding iminophophoranes. The Staudinger Ligation: A High-Yield, Chemoselective, and Mild Synthetic Method.
Click Chemistry
Click Chemistry a newer approach to the synthesis of drug-like molecules that can accelerate the drug discovery process by utilizing a few practical and reliable reactions.
GlycoProfile™ Azido Sugars
The GlycoProfile™ Azido Sugar portfolio consists of three peracetylated azido sugars that may be incorporated into glycan structures chemically or by using existing biosynthetic pathways of mammalian cells.
Click Chemistry in Drug Discovery
Drug discovery process by utilizing chemistry reaction of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes with organoazides to yield 1,4-disubstituted 1,2,3-triazoles.