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Zhu-Xu Zhang et al.
Transplantation, 98(10), 1029-1039 (2014-10-07)
Approximately 50% of cardiac transplants fail in the long term, and currently, there are no specific treatments to prevent chronic rejection. In the clinic, donor cardiac graft ischemia time is limited to within a few hours and correlates with delayed
Weiwei Qi et al.
Diabetes, 64(4), 1407-1419 (2014-11-05)
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels of pigment epithelium-derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and in db/db
Lizette Utomo et al.
Biomedical materials (Bristol, England), 10(1), 015010-015010 (2015-01-15)
Scaffolds are widely used to reconstruct cartilage. Yet, the fabrication of a scaffold with a highly organized microenvironment that closely resembles native cartilage remains a major challenge. Scaffolds derived from acellular extracellular matrices are able to provide such a microenvironment.
Bumpei Samata et al.
Journal of neuroscience methods, 243, 68-77 (2015-02-11)
To evaluate the in vivo function of human dopaminergic (DA) neurons, Parkinson's disease (PD) model rats made by the hemi-lateral injection of 6-hydroxydopamine (6-OHDA) are widely used as host animals. In the case of such xeno-transplantation, however, immunosuppression is needed
Reuven Edri et al.
Nature communications, 6, 6500-6500 (2015-03-24)
Decoding heterogeneity of pluripotent stem cell (PSC)-derived neural progeny is fundamental for revealing the origin of diverse progenitors, for defining their lineages, and for identifying fate determinants driving transition through distinct potencies. Here we have prospectively isolated consecutively appearing PSC-derived
Jiovanni A Di Battista et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(11), 907-917 (2014-08-08)
The effect of in vitro expansion of human adipose-derived stem cells (ASCs) on stem cell properties is controversial. We examined serial subcultivation with expansion on the ability of ASCs to grow and differentiate into osteoblastic lineages. Flow cytometric analysis, growth
Sebastien Hagmann et al.
BMC musculoskeletal disorders, 15, 322-322 (2014-09-30)
While numerous subpopulations of BM-MSCs have been identified, the relevance of these findings regarding the functional properties remains mostly unclear. With regards to attempts of enhancing differentiation results by preselecting certain MSC subtypes, we have evaluated the efficiency of CD146
Yuichiro Shirai et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(2), 498-507 (2014-11-12)
To clarify the role of pentraxin 3 (PTX3), a multifunctional pattern recognition protein that can suppress fibroblast growth factor 2 (FGF-2), in systemic sclerosis (SSc)-related vasculopathy. We assessed 171 SSc patients and 19 age- and sex-matched healthy control subjects. Circulating
Angel A Carbonell-Barrachina et al.
Food chemistry, 167, 387-395 (2014-08-26)
Phytochemical profiles of 24 quince liquors were studied as the combination of technologically variant. Liquors were obtained after macerating quinces from three varieties (Vranja, ALM3 and ZM2), with or without skin, at two ratios of quince:ethanol (50:50 and 25:75), and
Hakki Mevlut Ozcan et al.
Artificial cells, nanomedicine, and biotechnology, 42(4), 256-261 (2013-02-01)
In this study, a novel fresh broad (Vicia faba) tissue homogenate-based biosensor for determination of phenolic compounds was developed. The biosensor was constructed by immobilizing tissue homogenate of fresh broad (Vicia faba) on to glassy carbon electrode. For the stability
J Fuchs
Free radical biology & medicine, 25(7), 848-873 (1998-11-21)
Sun exposure has been linked to several types of skin damage including sun burn, photoimmunosuppression, photoaging and photocarcinogenesis. In view of the increasing awareness of the potentially detrimental long term side effects of chronic solar irradiation there is a general
Yang Ho Kang et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(2), 111-118 (2015-03-03)
Osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL)/receptor activator of NF-κB (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high glucose (HG) and phosphate (HP) condition for a long-term period
Hen-Yu Liu et al.
Biomaterials, 35(37), 9767-9776 (2014-09-23)
Aging is related to loss of functional stem cell accompanying loss of tissue and organ regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant
Foram Ranjeet Madiyar et al.
Nanoscale, 7(8), 3726-3736 (2015-02-03)
This work reports a synergistic approach to the concentration, detection and kinetic monitoring of pathogens through the integration of nanostructured dielectrophoresis (DEP) with nanotag-labelled Surface Enhanced Raman Spectroscopy (SERS). A nanoelectrode array made of embedded Vertically Aligned Carbon Nanofibers (VACNFs)
Hyung Ho Yoon et al.
Journal of Korean medical science, 29(11), 1555-1561 (2014-11-20)
A double toxin-double lesion strategy is well-known to generate a rat model of striatonigral degeneration (SND) such as multiple system atrophy-parkinsonian type. However, with this model it is difficult to distinguish SND from Parkinson's disease (PD). In this study, we
Yang-peng Sun et al.
PloS one, 9(7), e101896-e101896 (2014-07-09)
Multipotent mesenchymal stem cells (MSCs) found in the synovial fluid (SFMSCs) of the tempromandibular joint (TMJ) remain poorly understood. During TMJ arthrocentesis, we discovered that synovial fluid collected from some patients with TMJ disorders contained not only SFMSCs but also
Tran Thi Nhung et al.
Journal of nanoscience and nanotechnology, 13(8), 5346-5350 (2013-07-26)
Flowerlike gold nanostructure was facilely prepared by the seed-mediated growth of gold nanoparticles in chitosan-TPP template films. Firstly, chitosan nanoparticles, spontaneously formed by inter and/or intra cross-linking with TPP, were transformed into gel-type of chitosan-TPP films under strong sonication process.
Parid Sava et al.
Microcirculation (New York, N.Y. : 1994), 22(1), 54-67 (2014-09-13)
Neutrophil extravasation at post-capillary venules, consisting of EC, PC, and the shared ECM, increases following fibrotic remodeling in the lung, liver, and skin. The role of fibrotic pericyte-derived ECM in regulating EC activation and neutrophil recruitment remains unexplored. To elucidate
Mohamed M M Abdel-Latif et al.
European journal of cancer (Oxford, England : 1990), 51(4), 464-472 (2015-01-19)
Nuclear factor-kappaB (NF-κB) regulates the expression of a large number of genes involved in the immune and inflammatory response. NF-κB is constitutively activated in oesophageal tumour tissues and induced in oesophageal cells by bile and acid. The aim of the
Curt T Dellavalle et al.
International journal of cancer, 134(12), 2917-2926 (2013-11-19)
Nitrate and nitrite are precursors of endogenously formed N-nitroso compounds (NOC), known animal carcinogens. Nitrosation reactions forming NOCs can be inhibited by vitamin C and other antioxidants. We prospectively investigated the association between dietary nitrate and nitrite intake and risk
Wei-Li Fu et al.
Tissue engineering. Part A, 21(5-6), 948-959 (2014-10-10)
Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) derived from
Tanya Zappitelli et al.
Molecular biology of the cell, 26(5), 832-842 (2015-01-09)
Gja1(Jrt)/+ mice carry a mutation in one allele of the gap junction protein α1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negative for Cx43 protein production of <50% of wild-type (WT) levels and
Maciej Jarosz et al.
Analytica chimica acta, 851, 72-77 (2014-12-03)
Electrospray ionization mass spectrometry (ESI-MS) techniques have been used to characterize the speciation of a Ru(III) anticancer drug, indazolium trans-[tetrachloridobis(1H-indazole) ruthenate(III)], upon its binding to transferrin and the impact of cellular reducing components on drug-transferrin adducts. Using time-of-flight ESI-MS, the
Cecilia Granéli et al.
Stem cell research, 12(1), 153-165 (2013-11-19)
Today, the tool that is most commonly used to evaluate the osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro is the demonstration of the expression of multiple relevant markers, such as ALP, RUNX2 and OCN. However, as yet
Remedios Castelló-Cros et al.
Methods in molecular biology (Clifton, N.J.), 522, 275-305 (2009-02-28)
It is increasingly recognized that interactions between cancer cells and their surrounding stroma are critical for promoting the growth and invasiveness of tumors. For example, cancer cells alter the topography and molecular composition of stromal extracellular matrix by increasing paracrine
Susan J Zunino et al.
The British journal of nutrition, 112(3), 369-380 (2014-05-17)
Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60
Francesca Veronesi et al.
Cytotherapy, 17(2), 215-223 (2014-12-09)
Tendon is a complex tissue with a reduced regenerative ability. Nowadays, little or nothing is known about the regenerative effect of adipose-derived mesenchymal stromal cells (ADSCs) on tendons. The study aimed to evaluate the in vitro mutual interaction of ADSCs
Chee Shan Lim et al.
Physical chemistry chemical physics : PCCP, 16(24), 12178-12182 (2014-05-13)
Graphene materials are very popular in the field of biosensing owing to their distinctive characteristics. However, oxygen-containing groups are known to exist intrinsically in graphene-related materials. These groups influence the electrochemical properties of graphene materials and therefore affect the sensing
Hee-Jeong Jang et al.
Journal of the American Chemical Society, 136(50), 17674-17680 (2014-11-21)
Surface plasmonics of nanomaterials has been one of the main research themes in nanoscience. Spherical and elongated nanoparticles show their corresponding unique optical features mainly depending on the physical dimensions. Here we successfully synthesized Au nanorings having Pt framework (Pt@Au
Noriaki Kawanabe et al.
Clinical oral investigations, 19(2), 363-371 (2014-05-28)
It is well accepted that stage-specific embryonic antigen (SSEA)-4 is an antigen that is useful to isolate adult stem cells analogous to embryonic stem cells. Therefore, in the present study, we investigated whether SSEA-4 can also be used as a
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