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S A Kocoshis et al.
Annals of clinical and laboratory science, 21(3), 197-204 (1991-05-01)
Previous studies by us suggested that luminally administered sodium salicylate blocks dihydroxy-bile acid-induced colonic secretion in the rat. In the present study, an in vivo rat cecal loop technique is employed to compare the effects of luminally administered and parenterally
Hans F N Kvitvang et al.
Analytical chemistry, 83(7), 2705-2711 (2011-03-11)
Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few internal standards representing all metabolites, the ultimate requirement for a quantitative description of
Carlos Augusto Manacorda et al.
Molecular plant-microbe interactions : MPMI, 26(12), 1486-1498 (2013-08-16)
Losses produced by virus diseases depend mostly on symptom severity. Turnip mosaic virus (TuMV) is one of the most damaging and widespread potyvirus infecting members of the family Brassicaceae, including Arabidopsis thaliana. We used JPN1 and UK1 TuMV strains to
S Zaugg et al.
Journal of chromatography. B, Biomedical sciences and applications, 752(1), 17-31 (2001-03-20)
Acetylsalicylic acid (Aspirin) is rapidly metabolized to salicylic acid (salicylate) and other compounds, including gentisic acid and salicyluric acid. Monitoring of salicylate and its metabolites is of toxicological, pharmacological and biomedical interest. Three capillary electrophoresis (CE) methods featuring alkaline aqueous
F P Schmook et al.
International journal of pharmaceutics, 215(1-2), 51-56 (2001-03-16)
For the study of in-vitro skin penetration of candidate drugs, excised animal skin is frequently used as a replacement for human skin. Reconstructed human skin or epidermis equivalents have been proposed as alternatives. We compared the penetration properties of human
Daisuke Igarashi et al.
PloS one, 8(4), e60769-e60769 (2013-04-06)
Programmed cell death (PCD) is a crucial process for plant innate immunity and development. In plant innate immunity, PCD is believed to prevent the spread of pathogens from the infection site. Although proper control of PCD is important for plant
Mariana Rivas-San Vicente et al.
Journal of experimental botany, 62(10), 3321-3338 (2011-03-02)
In recent years salicylic acid (SA) has been the focus of intensive research due to its function as an endogenous signal mediating local and systemic plant defence responses against pathogens. It has also been found that SA plays a role
Sreeman K Mamidyala et al.
Bioorganic & medicinal chemistry letters, 23(6), 1667-1670 (2013-02-19)
Anacardic acid derivatives exhibit a broad range of biological activities. In this report, an efficient method for the synthesis of anacardic acid derivatives was explored, and a small set of salicylic acid variants synthesised retaining a constant hydrophobic element (a
A Z Khan et al.
The Journal of pharmacy and pharmacology, 41(10), 710-711 (1989-10-01)
A sequential approach is presented to the problem of determining the minimum number of blood samples needed to calculate the plasma to saliva concentration ratio to a required precision. The method was applied to salicylate concentrations obtained from six rheumatoid
Brinderjit Singh et al.
Gene, 532(2), 177-185 (2013-10-03)
The gene encoding eIF3g (TaeIF3g), one of the 11 subunits of eukaryotic translation initiation factor 3 (eIF3), was cloned from wheat for carrying out its functional analysis. Transgenic expression of TaeIF3g enhanced the tolerance of TaeIF3g-overexpressing parental yeast cells and
Zhixiang Chen et al.
Plant signaling & behavior, 4(6), 493-496 (2009-10-10)
Salicylic acid (SA) is an important signal molecule in plants. Two pathways of SA biosynthesis have been proposed in plants. Biochemical studies using isotope feeding have suggested that plants synthesize SA from cinnamate produced by the activity of phenylalanine ammonia
Sílvia Rocha-Rodrigues et al.
Life sciences, 93(8), 329-337 (2013-07-23)
Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic
Raimo A Ketola et al.
Forensic science international, 249, e7-11 (2015-02-17)
Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extracts were
M Berkovitch et al.
Therapeutic drug monitoring, 22(6), 757-761 (2000-12-29)
Drug assays may yield false-positive results caused by cross-reacting compounds. After finding a serum salicylate concentration of 81 microg/mL by using Trinder's colorimetric method, in a comatose child admitted to the authors' pediatric intensive care unit, in the absence of
Roger Fuoco et al.
Journal of plant physiology, 170(7), 668-675 (2013-02-12)
Recently our findings have shown that the integration of the gene coding for the rat gluco-corticoid receptor (GR receptor) in Nicotiana langsdorffii plants induced morphophysiological effects in transgenic plants through the modification of their hormonal pattern. Phytohormones play a key
Mahesh P Paudyal et al.
Bioorganic & medicinal chemistry, 22(24), 6781-6788 (2014-12-04)
Previously, we identified a class of salicylic acid derivatives that display inhibitory activity against the protein tyrosine phosphatase YopH from Yersinia pestis. Because docking study suggested that the large phenyl ring attaching to the salicylic acid core might be exposed
Sang-Keun Oh et al.
FEBS letters, 588(7), 1109-1115 (2014-03-04)
The Rpi-blb2 recognizes the presence of the Phytophthora infestans AVRblb2 and initiates effector-triggered immunity (ETI). We performed gain-of-function and loss-of-function studies in Nicotiana benthamiana to elucidate Rpi-blb2-mediated resistance to P. infestans. Rpi-blb2 triggered a hypersensitive response through SGT1-mediated, but not
Xiao-Feng Wu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 19(37), 12245-12248 (2013-08-14)
Cute CO! An interesting and straightforward procedure for the carbonylative synthesis of chromenones from readily available salicylic aldehydes and benzyl chlorides has been developed (see scheme; DPPP = 1,3-bis(diphenylphosphino)propane). In the presence of a palladium catalyst, various coumarins were produced
Dorothea Ellinger et al.
Plant physiology, 161(3), 1433-1444 (2013-01-22)
A common response by plants to fungal attack is deposition of callose, a (1,3)-β-glucan polymer, in the form of cell wall thickenings called papillae, at site of wall penetration. While it has been generally believed that the papillae provide a
Pityriasis folliculorum: a novel therapy for a diagnostically challenging condition.
Adam J Tinklepaugh et al.
Journal of the American Academy of Dermatology, 69(5), e276-e277 (2013-10-16)
Salicylic acid-, jasmonic acid- and ethylene-mediated regulation of plant defense signaling.
Aardra Kachroo et al.
Genetic engineering, 28, 55-83 (2006-12-13)
Sébastien Anthérieu et al.
Toxicology and applied pharmacology, 276(1), 63-72 (2014-02-15)
Drinking water can be contaminated with pharmaceuticals. However, it is uncertain whether this contamination can be harmful for the liver, especially during obesity. Hence, the goal of our study was to determine whether chronic exposure to low doses of pharmaceuticals
Mario Suwalsky et al.
Archives of biochemistry and biophysics, 539(1), 9-19 (2013-09-24)
Despite the well-documented information, there are insufficient reports concerning the effects of salicylate compounds on the structure and functions of cell membranes, particularly those of human erythrocytes. With the aim to better understand the molecular mechanisms of the interaction of
Yunlong Du et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7946-7951 (2013-04-25)
Removal of cargos from the cell surface via endocytosis is an efficient mechanism to regulate activities of plasma membrane (PM)-resident proteins, such as receptors or transporters. Salicylic acid (SA) is an important plant hormone that is traditionally associated with pathogen
Gangping Hao et al.
Plant physiology and biochemistry : PPB, 70, 21-32 (2013-06-19)
The enzyme 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) is a terminal-acting enzyme in the plastid MEP pathway, which produce isoprenoid precursors. The full-length cDNA of HDR, designated SmHDR1 (Genbank Accession No. JX516088), was isolated for the first time from Salvia miltiorrhiza Bge. f.
E Benfeldt et al.
Acta dermato-venereologica, 79(5), 338-342 (1999-09-24)
Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given 2 g acetylsalicylic acid orally. Blood samples and dialysates from 4 microdialysis probes inserted
Jyoti Shah
Current opinion in plant biology, 6(4), 365-371 (2003-07-23)
Salicylic acid is an important signal molecule in plant defense. In the past two years, significant progress has been made in understanding the mechanism of salicylic-acid biosynthesis and signaling in plants. A pathway similar to that found in some bacteria
Yucheng Sun et al.
Plant science : an international journal of experimental plant biology, 210, 128-140 (2013-07-16)
Rising atmospheric CO2 concentrations can affect the induced defense of plants against herbivory by chewing insects, but little is known about whether elevated CO2 can change the inducible defense of plants against herbivory by aphids, which are phloem-sucking rather than
Yogita Bansal et al.
Archives of pharmacal research, 37(11), 1426-1436 (2013-11-06)
Polyfunctional compounds comprise a novel class of therapeutic agents for treatment of multifactorial diseases. The present study reports a series of benzimidazole-non-steroidal anti-inflammatory drugs (NSAIDs) conjugates (1-10) as novel polyfunctional compounds synthesized in the presence of orthophosphoric acid. The compounds
Chongming Liu et al.
Journal of mass spectrometry : JMS, 49(8), 692-699 (2014-07-22)
On contrary to the widely accepted conviction that the m/z 93 ion derived from phenol does not react with CO2, we demonstrate that it makes an adduct with CO2 to a small but demonstrable extent. For example, the product-ion mass
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