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Mir-Jamal Hosseini et al.
Cell biochemistry and biophysics, 70(1), 367-381 (2014-04-03)
Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Besides, mitochondria are one of the most important targets for Cu(2+), an essential redox transition metal, induced hepatotoxicity. In this study, we aimed
Chunhui Ma et al.
Molecules (Basel, Switzerland), 19(12), 20821-20838 (2014-12-17)
Sustainable development of renewable resources is a major challenge globally. Biomass is an important renewable energy source and an alternative to fossil fuels. Pyrolysis of biomass is a promising method for simultaneous production of biochar, bio-oil, pyroligneous acid (PA), and
Sebastiaan Bijttebier et al.
Food chemistry, 165, 371-378 (2014-07-21)
Food processing enterprises produce enormous amounts of organic waste that contains valuable phytochemicals (e.g. C17-polyacetylenes). Knowledge on the phytochemicals content is a first step towards valorisation. Quantification of C17-polyacetylenes is however often hampered by the lack of commercially available standards
Mohammad M H Abdullah et al.
The British journal of nutrition, 113(3), 435-444 (2015-01-23)
Dairy products are rich sources of an array of fatty acids (FA) that have been shown individually and in certain clusters to exert varying effects on cardiovascular health, for which the circulating lipid profile is a powerful biomarker. Whether the
Yanmang Cui et al.
Chemico-biological interactions, 220, 75-83 (2014-06-29)
The study was to characterize the polyphenolic composition, antioxidant properties, and hepatoprotective effects of a polyphenols-enriched extract (HMTP) from Huangshan Maofeng green tea. HPLC analysis showed that three predominantly polyphenolic compounds present in HMTP were epigallocatechin (271.2 μg/mg extract), rutin
Daniela Rigano et al.
Fitoterapia, 99, 198-203 (2014-10-07)
A new acetophenone derivative named gnaphaliol 9-O-propanoate (1) was isolated from the chloroform fraction of EtOH extract of Helichrysum italicum ssp. italicum flowers along with the five known acetophenones 12-acetoxytremetone (2), 13-(2-methylpropanoyloxy)toxol (3), [2,3-dihydro-2-[1-(hydroxymethyl)ethenyl]-5-benzofuranyl]-ethanone (4), 1-[2-[1-[(acetyloxy)methyl]ethenyl]-2,3-dihydro-3-hydroxy-5-benzofuranyl]-ethanone (5) and gnaphaliol (6).
Krzysztof Kurek et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1074-1083 (2013-10-11)
Nonalcoholic fatty liver disease (NAFLD) is an insulin resistance-related hepatic disorder which can transform to cirrhosis. Insulin resistance deregulates hepatic lipid metabolism, leading to accumulation of cytotoxic lipids including ceramide and diacylglycerols. Myriocin, obtained from fungi traditionally used in Chinese
F Avila-Ramos et al.
Poultry science, 92(1), 243-249 (2012-12-18)
The oxidation of fatty acids decreases the quality and shelf-life of meats. To reduce this process, dietary supplemented and meat-added antioxidants were evaluated on the lipid oxidative stability of cooked chicken meat. Broilers were fed 2 levels of vitamin E
Melissa D Howard et al.
Molecular pharmaceutics, 11(7), 2262-2270 (2014-06-01)
Oxidative stress and inflammation are intertwined contributors to numerous acute vascular pathologies. A novel dual bioactive nanoparticle with antioxidant/anti-inflammatory properties was developed based on the interactions of tocopherol phosphate and the manganese porphyrin SOD mimetic, MnTMPyP. The size and drug
Norhayati Muhammad et al.
Molecules (Basel, Switzerland), 17(8), 9043-9055 (2012-08-01)
A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D
Dima Mnayer et al.
Molecules (Basel, Switzerland), 19(12), 20034-20053 (2014-12-04)
Six essential oils (EOs) from the Alliaceae family, namely garlic (Allium sativum), onion (Allium cepa), leek (Allium porrum), Chinese chive (Allium tuberosum), shallot (Allium ascalonicum) and chive (Allium schoenoprasum) were characterized by GC and GC-MS and evaluated for their functional
Pin Gong et al.
Environmental toxicology and pharmacology, 37(3), 1015-1027 (2014-04-23)
The oxidative status and morphological changes of mouse liver exposed to cadmium chloride (Cd(II)) and therapeutic potential of blueberry (Vaccinium corymbosum L.) extract against Cd(II)-induced hepatic injury were investigated. A variety of parameters were evaluated, including lipid peroxidation (LPO), protein
Suzan D Santos et al.
Journal of food science, 77(7), H141-H146 (2012-07-05)
Astaxanthin is a carotenoid known to have antioxidant and antiinflammatory properties. This study examined if shrimp astaxanthin modulates the production of superoxide (O(-)(2)), nitric oxide (NO), and tumor necrosis factor-α (TNF-α) in rat alveolar macrophages. The oxidative effect was induced
Modulation of tumor development by butylated hydroxytoluene in experimental animals.
H Witschi
Toxicology and industrial health, 9(1-2), 259-281 (1993-01-01)
Eric A Gurzell et al.
The Journal of nutritional biochemistry, 26(4), 369-377 (2015-01-27)
We previously reported that docosahexaenoic-acid (DHA)-enriched fish oil (DFO) feeding altered B-cell membrane organization and enhanced B-cell function. The purpose of this study was to evaluate whether menhaden oil (MO) and eicosapentaenoic-acid (EPA)-enriched fish oil (EFO) alters B-cell function/phenotype similarly.
Vijaya Karoor et al.
Cancer prevention research (Philadelphia, Pa.), 5(8), 1061-1071 (2012-06-16)
Patients with chronic obstructive pulmonary disease (COPD) are at an increased risk for the development of lung cancer, the mechanisms for which are incompletely understood. We hypothesized that the hypoxic pulmonary microenvironment present in COPD would augment lung carcinogenesis. Mice
Wan Mohd Nuzul Hakimi Wan Salleh et al.
Archives of pharmacal research, 38(4), 485-493 (2014-08-08)
The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase activities. The major constituents of the essential oils of leaf and bark of B. madang were
Krithika Lingappan et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 68-77 (2014-06-05)
Hyperoxia contributes to acute lung injury in diseases such as acute respiratory distress syndrome in adults and bronchopulmonary dysplasia in premature infants. Cytochrome P450 (CYP)1A1 has been shown to modulate hyperoxic lung injury. The mechanistic role(s) of CYP1A1 in hyperoxic
Mohammad Parwez Ahmad et al.
Pakistan journal of pharmaceutical sciences, 28(2), 509-513 (2015-03-03)
Lipopolysaccharide (LPS) induced oxidative stress and impairment of normal physiological function generally categorized by increased anxiety and reduced mobility. Therefore, the present study was to find out the effect Methanolic extract of Asparagus racemosus (MEAR ) in lipopolysaccharide (LPS)-induced oxidative
Gitte Krogh Nielsen et al.
PloS one, 6(11), e27287-e27287 (2011-11-11)
Niemann-Pick type C2 (NPC2) disease is a fatal autosomal recessive neurovisceral degenerative disorder characterized by late endosomal-lysosomal sequestration of low-density lipoprotein derived cholesterol. The breach in intracellular cholesterol homeostasis is caused by deficiency of functional NPC2, a soluble sterol binding
Sebastiaan Bijttebier et al.
Food chemistry, 163, 147-153 (2014-06-11)
Alkaline saponification is often used to remove interfering chlorophylls and lipids during carotenoids analysis. However, saponification also hydrolyses esterified carotenoids and is known to induce artifacts. To avoid carotenoid artifact formation during saponification, Larsen and Christensen (2005) developed a gentler
Joseph T Morott et al.
Journal of pharmaceutical sciences, 104(1), 124-134 (2014-11-21)
The primary aim of this research was to produce successfully taste masked formulations of Sildenafil Citrate (SC) using hot-melt extrusion (HME) technology. Multiple screw configurations and polymeric carriers were evaluated for their effects on taste masking efficiency, which was assessed
Bao-qiu Li et al.
Experimental biology and medicine (Maywood, N.J.), 239(10), 1366-1379 (2014-05-30)
Manganese (III) 5, 10, 15, 20-tetrakis [3-(2-(2-methoxy)-ethoxy) ethoxy] phenyl porphyrin chloride, designated HSJ-0017, is a novel antioxidant enzyme mimic. The aim of the present study was to investigate the enzyme-mimic activity and the therapeutic potential of HSJ-0017 in free radical-related
S Riedel et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 78, 96-104 (2015-02-07)
Changes in lipid metabolism have been associated with tumor promotion in rat liver. Similarities and differences of lipid parameters were investigated using the mycotoxin fumonisin B1 (FB1) and the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) treatments as cancer promoters in rat liver. A
Adam H Metherel et al.
Lipids in health and disease, 12, 22-22 (2013-02-22)
Dried blood spots (DBS) from fingertip prick blood can enable high throughput fatty acid profiling but may be prone to lipid peroxidation during storage. The use of butylated hydroxytoluene (BHT) on chromatography paper can prevent polyunsaturated fatty acid (PUFA) loss
Kabo Masisi et al.
Journal of agricultural and food chemistry, 63(10), 2715-2724 (2015-02-24)
The antioxidant potential of carotenoids from aleurone, germ, and endosperm fractions of barley, corn, and wheat has been evaluated. HPLC analysis confirmed the presence of lutein and zeaxanthin carotenoids (nd-15139 μg/kg) in extracts of cereal grain fractions. The antioxidant properties
Alexander N Patananan et al.
Archives of biochemistry and biophysics, 569, 32-44 (2015-02-11)
l-Ascorbate, commonly known as vitamin C, serves as an antioxidant and cofactor essential for many biological processes. Distinct ascorbate biosynthetic pathways have been established for animals and plants, but little is known about the presence or synthesis of this molecule
Val Andrew Fajardo et al.
Chemistry and physics of lipids, 187, 56-61 (2015-03-17)
Docosahexaenoic acid (DHA) can reduce the efficiency and increase the energy consumption of Na(+)/K(+)-ATPase pump and mitochondrial electron transport chain by promoting Na(+) and H(+) membrane permeability, respectively. In skeletal muscle, the sarco(endo) plasmic reticulum Ca(2+)-ATPase (SERCA) pumps are major
Sofia Windstam et al.
Applied and environmental microbiology, 74(14), 4292-4299 (2008-06-03)
The aim of this study was to determine the temporal release of fatty acids and sugars from corn and cucumber seeds during the early stages of seed germination in order to establish whether sugars found in exudate can prevent exudate
Min Mao et al.
PloS one, 9(10), e109722-e109722 (2014-10-21)
The present study is to investigate whether inflammatory cytokines inhibit ABCA1/ABCG1-mediated cholesterol efflux by regulating miR-33a-5P in THP-1 macrophages. We used interleukin-6 and tumor necrosis factor-alpha in the presence or absence of native low density lipoprotein (LDL) to stimulate THP-1
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