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sml0508

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Diana Silva et al.
International journal of pharmaceutics, 585, 119506-119506 (2020-06-09)
A layer-by-layer (LbL) coating was designed using ionic polysaccharides (chitosan, sodium alginate, sodium hyaluronate) and genipin (crosslinker), to sustain the release of diclofenac sodium salt (DCF) from soft contact lens (SCL) materials. The coating was hydrophilic, biocompatible, non-toxic, reduced bacterial
Gongfa Wang et al.
Cryobiology, 71(3), 464-471 (2015-09-27)
Oxidative stress plays an important role in sperm damage during cryopreservation. Mild mitochondrial uncoupling has been shown to reduce excessive reactive oxygen species (ROS) and thus mitigate oxidative stress. Uncoupling protein (Ucp2) regulates mitochondrial uncoupling and can be induced by
Lin Liu et al.
Pathogens (Basel, Switzerland), 9(9) (2020-08-28)
The intestinal protozoan parasite, Giardia duodenalis, infects a large number of people in the world annually. Giardia infection has been considered a negative effect on intestinal epithelial cell growth, while the underlying mechanisms remain to be explored. Here we evaluated
Fabiana Morroni et al.
International journal of molecular sciences, 19(7) (2018-07-20)
Alzheimer's disease (AD) is the most common form of dementia among older people. Although soluble amyloid species are recognized triggers of the disease, no therapeutic approach is able to stop it. 6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in
Alexandra A P Mansur et al.
Journal of materials chemistry. B, 8(32), 7166-7188 (2020-07-03)
Despite the undeniable advances in recent decades, cancer remains one of the deadliest diseases of the current millennium, where the triple-negative breast cancer (TNBC) is very aggressive, extremely metastatic, and resistant to conventional chemotherapy. The nanotheranostic approach focusing on targeting
S Sruthi et al.
Colloids and surfaces. B, Biointerfaces, 170, 454-462 (2018-06-30)
Iron oxide nanoparticles have the capability to cross Blood Brain Barrier (BBB) and hence are widely investigated for biomedical operations in the central nervous system. Before being used for the biomedical purpose, it is necessary to investigate its biocompatibility, dosimetry
Boyun Kim et al.
Oncotarget, 8(36), 60299-60311 (2017-09-28)
Malignant cells are subjected to high levels of oxidative stress that arise from the increased production of reactive oxygen species (ROS) due to their altered metabolism. They activate antioxidant mechanisms to relieve the oxidative stress, and thereby acquire resistance to
Thanasekaran Jayakumar et al.
International journal of molecular medicine, 39(1), 174-182 (2016-12-14)
Nobiletin, a bioactive polymethoxylated flavone, has been described to possess a diversity of biological effects through its antioxidant and anti-inflammatory properties. Vasodilator-stimulated phosphoprotein (VASP) is a common substrate for cyclic AMP and cyclic GMP-regulated protein kinases [i.e., cyclic AMP-dependent protein kinase (PKA; also known as protein
Changwon Yang et al.
Reproductive toxicology (Elmsford, N.Y.), 84, 49-58 (2019-01-01)
4-Methylbenzylidene-camphor (4-MBC) is an estrogenic compound used in a variety of personal care products and is associated with water pollution. In this study, we verified that exposure to 4-MBC suppresses the proliferation and invasiveness of the HTR8/SVneo human trophoblast cell
Nardine Safwat et al.
Journal of AOAC International, 104(1), 103-112 (2021-03-23)
Nowadays, emergence of unexpected contaminants in drinking water is a challenging environmental problem facing humanity. Two eco-friendly spectrofluorimetric methods were proposed for the determination of three unexpected contaminants in drinking tap water. The first method is first derivative synchronous spectrofluorimetric
Fanny Caputo et al.
Frontiers in pharmacology, 9, 1183-1183 (2018-11-22)
Cerium oxide nanoparticles (CNPs) are potent radical scavengers protecting cells from oxidative insults, including ionizing radiation. Here we show that CNPs prevent X-ray-induced oxidative imbalance reducing DNA breaks on HaCat keratinocytes, nearly abating mutagenesis. At the same time, and in
Azadeh Aminzadeh et al.
Fundamental & clinical pharmacology, 32(3), 261-269 (2018-02-13)
Homocysteine (Hcy) is a major risk factor for vascular disease and is closely associated with endothelial dysfunction. Melatonin is a neurohormone that is mostly produced by the pineal gland. Studies have reported that melatonin exhibits neuroprotective effects in several neurodegenerative
Agata Antosiak et al.
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 26(1), 64-73 (2017-01-24)
Genistein belongs to isoflavones, which are a subclass of flavonoids, a large group of polyphenolic compounds widely distributed in plants. Numerous in vitro studies suggest that isoflavones, particularly genistein, have both chemopreventive and chemotherapeutic potential in multiple tumor types. However
Shi-Jing Wang et al.
Canadian journal of physiology and pharmacology, 98(5), 259-266 (2019-12-12)
Mitochondrial dysfunctions are responsible for myocardial injury upon ischemia/reperfusion (I/R), and mitochondrial E3 ubiquitin ligase 1 (Mul1) plays an important role in maintaining mitochondrial functions. This study aims to explore the function of Mul1 in myocardial I/R injury and the
Miriam E Mossoba et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(11), 3697-3705 (2011-04-28)
The success of immunotoxin therapy of cancer is limited by host production of neutralizing antibodies, which are directed toward the Pseudomonas exotoxin A (PE) component. In this proof-of-principle study using a well-established murine model, we hypothesized that a newly developed
Lucas Pires Garcia Oliveira et al.
Life sciences, 217, 81-90 (2018-12-07)
Chemotherapy has been widely used to treat cancer although it may affect non-target cells involved in the immune response. This work aimed at elucidating whether the chemotherapeutic agent doxorubicin in combination with geopropolis produced by Melipona fasciculata Smith could affect
Mei-Hui Zhang et al.
Free radical biology & medicine, 164, 1-12 (2021-01-04)
Non-alcoholic steatohepatitis (NASH) is the progressive stage of non-alcoholic fatty liver disease that may ultimately lead to cirrhosis and liver cancer, and there are few therapeutic options for its treatment. Physalin B (PB), a withanolide isolated from Physalis species (Solanaceae)
Long term outcome of patients with steroid-refractory acute intestinal graft versus host disease after treatment with pentostatin.
Stefan A Klein et al.
British journal of haematology, 154(1), 143-146 (2011-04-12)
Xuesong Li et al.
International journal of nanomedicine, 10, 821-838 (2015-02-06)
To investigate the sonoactivity of hypericin (HY), together with its sonodynamic effect on THP-1 macrophages and the underlying mechanism. CCK-8 was used to examine cell viability. Confocal laser scanning microscopy was performed to assess the localization of HY in cells
Valeria Verde et al.
International journal of molecular sciences, 21(15) (2020-08-08)
Graphene oxide (GO) is a bidimensional novel material that exhibits high biocompatibility and angiogenic properties, mostly related to the intracellular formation of reactive oxygen species (ROS). In this work, we set up an experimental methodology for the fabrication of GO@peptide
Daniela Ailincai et al.
Journal of immunology research, 2020, 3124304-3124304 (2020-06-23)
The main aim of the paper was to simulate the drug release by a multifractal theoretical model, as a valuable method to assess the drug release mechanism. To do this, drug delivery films were prepared by mixing poly(vinyl alcohol boric
Yapeng Lu et al.
Scientific reports, 6, 39123-39123 (2016-12-17)
Hypoxia-inducible factor-1 (HIF-1) is an important transcription factor that induces adaptive responses upon low oxygen conditions in human cancers and triggers off a poor prognostic outcome of conventional treatments. In this study, we discovered for the first time that brusatol
Tamás Lőrincz et al.
Pathology oncology research : POR, 25(2), 669-679 (2018-11-18)
Pharmacologic ascorbate induced cell death and ferroptosis share common features such as iron dependency, production of ROS, lipid peroxidation, caspase independency and the possible involvement of autophagy. These observations lead us to hypothesize that ferroptosis may also be involved in
CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer.
Jie Xie et al.
Theranostics, 8(3), 650-662 (2018-01-19)
Lin Dang et al.
Oncology reports, 34(3), 1478-1486 (2015-07-03)
Skin cancer is one of the most common types of malignancy in the world. UV radiation is known as the primary environmental carcinogen responsible for skin cancer development. However, UV radiation is a ubiquitous substance existing in the environment and
Na Yeon Kim et al.
Antioxidants (Basel, Switzerland), 9(7) (2020-07-19)
Ribes diacanthum Pall (RDP) is a Mongolian traditional medicine used to treat renal inflammation. In the present study, we initially investigated the anti-inflammatory effects and mechanisms of action of ethylacetate extract of RDP (EARDP) in RAW 264.7 macrophages stimulated by
Valentina V Ignatova et al.
Genes & development, 34(9-10), 715-729 (2020-03-29)
Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, our mechanistic understanding of the enzymes catalyzing these modifications, their substrates and biological functions, remains vague. Amongst RNA modifications N6-methyladenosine (m6A) is widespread and found in messenger (mRNA)
Haiyan Liu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 125, 109943-109943 (2020-02-29)
Acute lung injury (ALI) is caused by severe infection, and urgently needs effective treatments or validated pharmacological targets. Formyl peptide receptor 2 (Fpr2) plays essential roles in immune responses and inflammatory diseases. In the present study, Fpr2 expression was markedly
Chencheng Feng et al.
International journal of molecular medicine, 41(6), 3422-3432 (2018-03-08)
High oxygen tension caused by neovascularization in the microenvironment of intervertebral discs (IVDs) is associated with the pathogenesis of IVD degeneration (IDD). Pre-mRNAs undergo alternative splicing (AS) to produce structurally and functionally diverse mRNA and proteins. However, the precise role
Shuang Peng et al.
Oncotarget, 7(49), 80262-80274 (2016-10-30)
In this study, we attempted to explore the effect and possible mechanism of Andrographolide on OVA-induced asthma. OVA challenge induced significant airway inflammatory cell recruitment and lung histological alterations, which were ameliorated by Andrographolide. The protein levels of cytokines in
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