Merck
  • A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.

A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2012-10-03)
Michael K Schultz, Dirk Mueller, Richard P Baum, G Leonard Watkins, Wouter A P Breeman
ABSTRACT

A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15 min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40 MBq nmole(-1) [(68)Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Citric acid monohydrate, ACS reagent, ≥99.0%
Sigma-Aldrich
Citric acid monohydrate, reagent grade, ≥98% (GC/titration)
Sigma-Aldrich
Acetic acid, glacial, ≥99.99% trace metals basis