914487

2-(Diphenylphosphanyl)benzamide

≥95%

• Synonym(s): 2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction
• Empirical Formula (Hill Notation): C₁₉H₁₆NOP
• CAS Number: 343254-74-0
• Molecular Weight: 305.31

Properties

• Quality Level: 100
• assay: ≥95%
• form: powder
• storage temp.: −20°C

Description

General description

It is recommended to make fresh stock stolutions prior to each use.

Application

2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N₃ (cat# 913812).

Packaging

50, 250 mg

Other Notes

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Small-molecule control of protein function through Staudinger reduction

A FRET-based ratiometric two-photon fluorescent probe for dual-channel imaging of nitroxyl in living cells and tissues

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3