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850365P

Avanti

18:0 PC (DSPC)

Avanti Polar Lipids

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Synonym(s):
1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; DSPC; PC(18:0/18:0)
Empirical Formula (Hill Notation):
C44H88NO8P
CAS Number:
Molecular Weight:
790.15
NACRES:
NA.25

description

1,2-distearoyl-sn-glycero-3-phosphocholine

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850365P-1G)
pkg of 1 × 200 mg (850365P-200MG)
pkg of 1 × 25 mg (850365P-25MG)
pkg of 1 × 500 mg (850365P-500MG)

manufacturer/tradename

Avanti Polar Lipids

application(s)

advanced drug delivery

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChI key

NRJAVPSFFCBXDT-HUESYALOSA-N

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18:0 PC (DSPC) Avanti Polar Lipids

850365P

18:0 PC (DSPC)

18:0 PC (DSPC) Avanti Polar Lipids

850365C

18:0 PC (DSPC)

18:1 (Δ9-Cis) PC (DOPC) Avanti Polar Lipids

850375P

18:1 (Δ9-Cis) PC (DOPC)

16:0 PC (DPPC) Avanti Polar Lipids

850355P

16:0 PC (DPPC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

powder

form

liquid

form

powder

form

powder

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

packaging

pkg of 1 × 1 g (850365P-1G), pkg of 1 × 25 mg (850365P-25MG), pkg of 1 × 200 mg (850365P-200MG), pkg of 1 × 500 mg (850365P-500MG)

packaging

pkg of 1 × 2.5 mL (850365C-25mg), pkg of 1 × 20 mL (850365C-500mg), pkg of 2 × 20 mL (850365C-1g), pkg of 2 × 4 mL (850365C-200mg)

packaging

pkg of 1 × 1 g (850375P-1g), pkg of 2 × 100 mg (850375P-200mg), pkg of 5 × 100 mg (850375P-500mg), pkg of 1 × 25 mg (850375P-25mg)

packaging

pkg of 1 × 1 g (850355P-1g), pkg of 1 × 200 mg (850355P-200mg), pkg of 1 × 25 mg (850355P-25mg), pkg of 1 × 500 mg (850355P-500mg)

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:0 PC (DSPC) has been used:
  • in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
  • in the preparation of liposomes for immobilization studies
  • in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.

Packaging

20 mL Clear Glass Screw Cap Vial (850365P-1G)
20 mL Clear Glass Screw Cap Vial (850365P-500MG)
5 mL Amber Glass Screw Cap Vial (850365P-200MG)
5 mL Amber Glass Screw Cap Vial (850365P-25MG)

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Comparative study of PEGylated and conventional liposomes as carriers for shikonin
Tsermentseli S, et al.
Fluids, 3(2), 36-36 (2018)
A coarse-grained molecular dynamics study of DLPC, DMPC, DPPC, and DSPC mixtures in aqueous solution
Abedi K, et al.
Journal of Chemistry, 2013 (2013)
Ana Reis et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183133-183133 (2019-12-01)
Food polyphenols in fruits juices, tea, coffee, wine and beer confer sensory properties such as colour, astringency and bitterness. The development of functional healthy drinks without the unpleasant sensory feeling is boosting research for a clearer understanding on the interactions
Investigating the structure of multicomponent gel-phase lipid bilayers
Hartkamp R, et al.
Biophysical Journal, 111(4), 813-823 (2016)
Kenneth L Clark et al.
Molecular therapy. Nucleic acids, 2, e65-e65 (2013-01-17)
Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC). To identify a small-interfering RNA (siRNA) which selectively inhibits ENaC expression

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