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10171832001

Roche

Aldehyde Dehydrogenase

from yeast

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Synonym(s):
Aldehyde dehydrogenase
Enzyme Commission number:

biological source

yeast

Quality Level

form

lyophilized

specific activity

~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)

packaging

pkg of 250 U

manufacturer/tradename

Roche

optimum pH

8.75

relevant disease(s)

cancer

storage temp.

2-8°C

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This Item
A9770A6338P4553
Aldehyde Dehydrogenase from yeast

10171832001

Aldehyde Dehydrogenase

biological source

yeast

biological source

yeast

biological source

-

biological source

yeast

form

lyophilized

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

optimum pH

8.75

optimum pH

-

optimum pH

-

optimum pH

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

General description

Aldehyde dehydrogenase (ALDH) is a soluble enzyme and its activity depends on potassium ions and cysteine. The family of ALDH comprises of 19 genes in human. ALDH gene is expressed in the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell. ALDH is a component of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) recycling systems.

Application

Aldehyde Dehydrogenase has been used to evaluate fiber-optic biosensors for measurement of acetaldehyde (AcH) in liquid phase (AcH biosensor).

Biochem/physiol Actions

Aldehyde dehydrogenase (ALDH) regulates the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic aldehydes. Mutations in this gene are associated with Sjogren Larsson syndrome, Larsson syndrome, type II hyperprolinemia and cancer. ALDH takes part in the oxidation of aldehydes to acids. ALDH-2 lowers cardiac ischemia, which arises due to myocardial infarction or post cardiac surgery.

Quality

Contaminants: <0.01% “NADH oxidase”, ADH, and LDH each

Physical form

Enzyme is stabilized with potassium phosphate buffer, pH approximately 6.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Inhalation

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

does not flash

Flash Point(C)

does not flash


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Improved sensitivity of acetaldehyde biosensor by detecting ADH reverse reaction-mediated NADH fluoro-quenching for wine evaluation
Iitani K, et al.
ACS sensors, 2(7), 940-946 (2017)
Yeast Aldehyde Dehydrogenase II. PROPERTIES OF THE HOMOGENEOUS ENZYME PREPARATIONS
Charles R. Steinman and WILLIAM B. JAKOBY
The Journal of Biological Chemistry, 243(4), 730-734 (1965)
Kenta Iitani et al.
Sensors (Basel, Switzerland), 23(13) (2023-07-14)
The molecule 2-nonenal is renowned as the origin of unpleasant human aging-related body odor that can potentially indicate age-related metabolic changes. Most 2-nonenal measurements rely on chromatographic analytical systems, which pose challenges in terms of daily usage and the ability
Yeast aldehyde dehydrogenase.
S BLACK
Archives of biochemistry and biophysics, 34(1), 86-97 (1951-11-01)
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
Chen CH, et al.
Science (New York, N.Y.), 321(5895), 1493-1495 (2008)

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