Merck

Tangential Flow Filtration Holders & Systems

Benefiting from our leading bioprocess knowledge and engineering expertise in tangential flow filtration (TFF), we have developed multi-use, single-use, and process development systems incorporating many unique, innovative, and intelligent features. Our systems are designed to meet the success criteria for purification by tangential filtration, including low hold-up volume, maximum volume concentration, and optimal product recovery for enhanced process performance.

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Mobius TFF 80 System, Single-use Tangential Flow Filtration Solution, Designed for Large Scale Processing

PROCESS-SCALE SINGLE-USE TFF SYSTEMS

Our Mobius® FlexReady Solution for TFF and Mobius® TFF 80 system provide a combination of single-use Flexware® assemblies and hardware specifically designed for efficient concentration and diafiltration of proteins. With installable filter area ranging from 0.5 to 20 m2, flow range from 2 to 80 L/min, and tank size from 50 to 500 L, our range of single-use TFF systems can adapt to your process needs from pre-clinical to manufacturing scale. Closed mode of operation is possible with specifically designed flowpath and equipment, allowing to reduce contamination risk and protect operators while increasing flexibility and efficiency. This family of equipment features:

  • Clinical to large scale capabilities, with no compromise on quality
  • Design for optimized yield and product recovery
  • Multi-product and multi-processing modes
  • Full automation, user friendly
Cogent® Process-Scale Tangential Flow Filtration System, ideally suited for both pilot and production scale

Process-scale multi-use TFF systems

The fully automated Cogent® Process-Scale TFF System is designed to separate and purify monoclonal antibodies, vaccines, plasma, and therapeutic proteins. It is ideally suited for both pilot and production scale applications, thereby supporting rapid scale-up from small- to large-scale operations. Other key system features include:

  • Modular options for the system configuration that best matches process requirements, while minimizing upfront investment
  • Full process automation
  • Optimized design and component integration of NovAseptic® valves and TFF cassette holders for lowest minimum working volume and maximum product recovery
  • Processes operated in fed-batch, concentration, total recycle, or single-pass mode.
Cogent® Process-Scale Tangential Flow Filtration System, ideally suited for both pilot and production scale

PROCESS DEVELOPMENT TFF SYSTEMS

Our family of Cogent® Lab systems uses similar design, sensing technologies, and accessories as our manufacturing-scale equipment. With a homogeneous design and flow range from 20 to 6000 mL/min, our systems have been specifically created to simplify process development. The Cogent® Lab 150, 800, and 6000 systems are optimized for high product recovery and drainability, ensuring successful small-scale TFF operations.

  • One family of TFF systems with harmonized design and linear performance ensures successful and seamless scale-up or scale-down
  • User-friendly Bio4C® Control Software offers pre-defined recipe steps, real-time data visualization and export capabilities assuring reliable and reproducible results
  • Cogent® Lab systems can be tailored to your specific process with an extensive list of options
  • Flexibly operates in UF/DF, microfiltration or SPTFF mode and across a wide range of parameters

Holders for Pellicon® flat sheet devices

Our systems are best suited for use with Pellicon® expendables, either in single-use (Pellicon® Capsule) or multi-use applications (Pellicon® 2 and 3). Holders may be included when purchasing a TFF system; please refer to the appropriate data sheet for details. We provide self-standing holders for filtration area from 88 cm² to 130 m² depending on expendables.

  • XX42PMICR0 holder for Pellicon® 3 micro from 88 cm² to 264 cm²
  • XX42PMINI holder for Pellicon® 2 and 3 from 0.1 m² to 0.55 m²
  • Pellicon® Process scale holders for Pellicon® 2 and 3 from 0.5 m² and above

Options are available to increase the installed surface and run in single-pass mode.


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