106-50-3

Applied Filters:

Keyword:'106-50-3'

Showing 1-30 of 117 results for "106-50-3" within Papers

Interactions of the prion peptide (PrP 106-126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions.

Itzik Cooper et al.

Journal of neurochemistry, 116(4), 467-475 (2010-09-02)

We studied here the interactions of PrP 106-126, a peptide corresponding to the prion protein (PrP) amyloidogenic region, with a blood-brain barrier in vitro model consisting of confluent porcine brain endothelial cells (PBEC). PrP 106-126 interacted selectively with PBEC via

Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial.

John Fr Robertson et al.

The Lancet. Oncology, 14(3), 228-235 (2013-02-19)

Insulin-like growth factors (IGF-1 and IGF-2) bind to the IGF-1 receptor (IGF-1R), increasing cell proliferation and survival. Ganitumab is a monoclonal IgG1 antibody that blocks IGF-1R. We tested the efficacy and safety of adding ganitumab to endocrine treatment for patients

Meglumine diatrizoate esophagogram after peroral endoscopic myotomy (POEM): identification of imaging findings associated with clinical complications and longer hospital stay.

Maximilien Barret et al.

European radiology, 30(8), 4175-4181 (2020-03-15)

Esophageal peroral endoscopic myotomy (POEM) is the treatment of reference of major obstructive esophageal motility disorders but the detection of early complications remains challenging. Our aim was to report the radiological findings on meglumine diatrizoate esophagograms after esophageal POEM and

A phase I trial of WRSS1, a Shigella sonnei live oral vaccine in Bangladeshi adults and children.

Rubhana Raqib et al.

Human vaccines & immunotherapeutics, 15(6), 1326-1337 (2019-02-23)

Shigella sonnei live vaccine candidate, WRSS1, which was previously evaluated in US, Israeli and Thai volunteers, was administered orally to Bangladeshi adults and children to assess its safety, clinical tolerability and immunogenicity. In a randomized, placebo-controlled, dose-escalation, age-descending study, 39

Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels.

Samir Al-Bulushi et al.

PloS one, 14(11), e0224992-e0224992 (2019-11-08)

This study was conducted to evaluate various factors affecting fertility following insemination of dromedary camels. In experiment 1, camels were either bred by natural mating (NM) or inseminated in the body of uterus with whole, split (50:50) or 1 mL

Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

Alpa Khatri et al.

Molecular pharmacology, 86(5), 548-560 (2014-09-11)

NMDA receptors are tetrameric complexes of GluN1, GluN2A-D, and GluN3A-B subunits and are involved in normal brain function and neurologic disorders. We identified a novel class of stereoselective pyrrolidinone (PYD) positive allosteric modulators for GluN2C-containing NMDA receptors, exemplified by methyl

Impact of maternal and neonatal factors on parameters of hematopoietic potential in umbilical cord blood.

Sara Y Al-Deghaither

Saudi medical journal, 36(6), 704-712 (2015-05-20)

To determine characteristics of laboratory parameters of hematopoietic potential in umbilical cord blood and their association with maternal and neonatal factors. This prospective analysis was performed on 206 umbilical cord blood donations (50-200 ml) from King Faisal Specialist Hospital and

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

D Riendeau et al.

The Journal of pharmacology and experimental therapeutics, 296(2), 558-566 (2001-02-13)

We report here the preclinical profile of etoricoxib (MK-0663) [5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) pyridine], a novel orally active agent that selectively inhibits cyclooxygenase-2 (COX-2), that has been developed for high selectivity in vitro using whole blood assays and sensitive COX-1 enzyme assays at

Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells.

C O Quinn et al.

The Journal of biological chemistry, 265(36), 22342-22347 (1990-12-25)

We have isolated clones for rat collagenase from a rat osteoblastic cell cDNA library. These clones have been sequenced and the amino acids deduced. The calculated molecular weight is 51,352 for the proenzyme and 42,229 for the active enzyme. The

Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells.

Amareshwar T K Singh et al.

Lipids, 40(11), 1135-1140 (2006-02-08)

Parathyroid hormone (PTH) and phorbol-12,13-dibutyrate (PDBu) stimulate phospholipase D (PLD) activity and PC hydrolysis in UMR-106 osteoblastic cells {Singh, A.T., Kunnel, J.G., Strieleman, P.J., and Stern, P.H. (1999) Parathyroid Hormone (PTH)-(1-34), [Nle8,18,Tyr34]PTH-(3-34) Amide, PTH-(1-31) Amide, and PTH-Related Peptide-(1-34) Stimulate Phosphatidylcholine

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

Chelliah Selvam et al.

Journal of medicinal chemistry, 53(7), 2797-2813 (2010-03-12)

(R)-PCEP (3-amino-3-carboxypropyl-2'-carboxyethyl phosphinic acid, 1), a new metabotropic glutamate receptor 4 (mGlu4R) agonist, was discovered in a previously reported virtual screening. The (S)-enantiomer and a series of derivatives were synthesized and tested on recombinant mGlu4 receptors. A large number of

Introduction of a novel prototype bioartificial liver support system utilizing small human hepatocytes in rotary culture.

Martin Wurm et al.

Tissue engineering. Part A, 15(5), 1063-1073 (2008-10-14)

The aim of this study was to establish a stand-alone, perfused, rotary cell culture system using small human hepatocytes (SH) for bioartificial liver (BAL) support. SH were grown on cytodex 3 microcarriers (beads) to a maximum density of 1.2 +/-

Comparative rates of metabolism of pipecolic acid in several animal species.

J Dancis et al.

Comparative biochemistry and physiology. B, Comparative biochemistry, 73(4), 1011-1012 (1982-01-01)

1. The rate of metabolism of pipecolic acid, measured in liver and kidney, varied 1000 fold among 10 animal species. Degradation of L-pipecolic acid by kidney in rat and mouse was 0.11 and 0.31 pmoles/min/mg protein, respectively; in monkey and

The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis.

Zhiqiang Li et al.

Biochimica et biophysica acta, 1735(2), 130-134 (2005-06-22)

Sphingomyelin (SM) plays a very important role in cell membrane formation and plasma lipoprotein metabolism. All these functions may have an impact on atherosclerotic development. To investigate the relationship between SM metabolism and atherosclerosis, we utilized a sphingolipid-rich diet to

[Simultaneous determination of captan and folpet pesticide residues in apples by solid-phase extraction and high performance liquid chromatography].

Shuju Wang et al.

Se pu = Chinese journal of chromatography, 25(2), 226-229 (2007-06-22)

A method for the simultaneous determination of captan and folpet pesticide residues in apples was developed by solid-phase extraction and high performance liquid chromatography. The sample was extracted with acetonitrile and cleaned-up by a mixture of homemade sorbent and silica

[(99m)Tc]Demomedin C, a radioligand based on human gastrin releasing peptide(18-27): synthesis and preclinical evaluation in gastrin releasing peptide receptor-expressing models.

Berthold A Nock et al.

Journal of medicinal chemistry, 55(19), 8364-8374 (2012-09-13)

The synthesis and preclinical evaluation of [(99m)Tc]Demomedin C in GRPR-expressing models are reported. Demomedin C resulted by coupling a Boc-protected N(4)-chelator to neuromedin C (human GRP(18-27)), which, after (99m)Tc-labeling, afforded [(99m)Tc]Demomedin C. Demomedin C showed high affinity and selectivity for

Carcinogenesis bioassay in rats and mice fed diets containing 2-biphenylamine hydrochloride.

K M Abdo et al.

Fundamental and applied toxicology : official journal of the Society of Toxicology, 2(5), 201-210 (1982-09-01)

Diets containing 0.1 or 0.3% 2-biphenylamine hydrochloride were fed to groups of 50 Fischer 344 rats and 50 B6C3F1 mice of each sex for 104-106 weeks. Mean body weights of high-dose rats of both sexes and of low-dose male rats

Online measurement of oxygen enables continuous noninvasive evaluation of human-induced pluripotent stem cell (hiPSC) culture in a perfused 3D hollow-fiber bioreactor.

Selina Greuel et al.

Journal of tissue engineering and regenerative medicine, 13(7), 1203-1216 (2019-04-30)

For clinical and/or pharmaceutical use of human-induced pluripotent stem cells (hiPSCs), large cell quantities of high quality are demanded. Therefore, we combined the expansion of hiPSCs in closed, perfusion-based 3D bioreactors with noninvasive online monitoring of oxygen as culture control

Synthesis of Ultrahigh Molecular Weight Polymers Containing Reactive Functionality with Low PDIs by Polymerizations of Long-Chain α-Olefins in the Presence of Their Nonconjugated Dienes by Cp*TiMe2(O-2,6-iPr2C6H3)-Borate Catalyst.

Kotohiro Nomura et al.

Polymers, 12(1) (2019-12-22)

Copolymerizations of 1-decene (DC) with 1,9-decadiene (DCD), 1-dodecene (DD) with 1,11-dodecadiene (DDD), and 1-tetradecene (TD) with 1,13-tetradecadiene (TDD), using Cp*TiMe2(O-2,6-iPr2C6H3) (1)-[Ph3C][B(C6F5)4] (borate) catalyst in the presence of AliBu3/Al(n-C8H17)3 proceeded in a quasi-living manner in n-hexane at -30 to -50 °C

Site-specific phosphorylation of phosducin in intact retina. Dynamics of phosphorylation and effects on G protein beta gamma dimer binding.

Bruce Y Lee et al.

The Journal of biological chemistry, 279(52), 54008-54017 (2004-10-16)

Phosducin (Pdc) is a G protein beta gamma dimer (G beta gamma) binding protein, highly expressed in retinal photoreceptor and pineal cells, yet whose physiological role remains elusive. Light controls the phosphorylation of Pdc in a cAMP and Ca(2+)-dependent manner

Prostaglandin E2 stimulates bone sialoprotein (BSP) expression through cAMP and fibroblast growth factor 2 response elements in the proximal promoter of the rat BSP gene.

Hiroshi Samoto et al.

The Journal of biological chemistry, 278(31), 28659-28667 (2003-05-27)

Bone sialoprotein (BSP), an early marker of osteoblast differentiation, has been implicated in the nucleation of hydroxyapatite during de novo bone formation. Prostaglandin E2 (PGE2) has anabolic effects on proliferation and differentiation of osteoblasts via diverse signal transduction systems. Because

The action of thrombin on peptide p-nitroanilide substrates: hydrolysis of Tos-Gly-Pro-Arg-pNA and D-Phe-Pip-Arg-pNA by human alpha and gamma and bovine alpha and beta-thrombins.

R Lottenberg et al.

Thrombosis research, 28(3), 313-332 (1982-11-01)

Human and bovine alpha-thrombins (greater than 90% alpha form) with high fibrinogen clotting activities (approximately 3,000 U.S. units/mg protein) exhibit similar Michaelis menten kinetics with the p-nitroanilide tripeptide substrates Tos-Gly-Pro-arg-pNA (Chromozym-TH) and D-Phe-Pip-Arg-pNA (S-2238). The kinetic parameters at I =

Coronary In-Stent Restenosis: Assessment with Corrected Coronary Opacification Difference across Coronary Stents Measured with CT Angiography.

Yang Gao et al.

Radiology, 275(2), 403-412 (2014-12-19)

To determine whether changes in coronary opacification normalized to the aorta (corrected coronary opacification [CCO]) across stents can help identify in-stent restenosis (ISR) severity with use of invasive coronary angiography as the standard of reference. This study was approved by

Kinematic, bioenergetic and oxidative evaluations of donkey sperm preserved at +4°C.

Tommaso Di Palma et al.

Zygote (Cambridge, England), 28(4), 300-307 (2020-04-15)

Information on donkey sperm bioenergetics, kinetics and oxidative status is scarce even though crucial for development of reproductive technologies and germplasm conservation. For these reasons, it is interesting to monitor sperm kinetics, bioenergetics, and oxidative status during sperm storage at

Plasma capric acid concentrations in healthy subjects determined by high-performance liquid chromatography.

Rojeet Shrestha et al.

Annals of clinical biochemistry, 52(Pt 5), 588-596 (2015-01-15)

Capric acid (FA10:0, decanoic acid) is a medium-chain fatty acid abundant in tropical oils such as coconut oil, whereas small amounts are present in milk of goat, cow, and human. Orally ingested FA10:0 is transported to the liver and quickly

Liquid chromatographic determination of fumonisins B1, B2, and B3 in corn silage.

Eun-Kyung Kim et al.

Journal of agricultural and food chemistry, 52(2), 196-200 (2004-01-22)

Corn silage was dried, ground, and then extracted with 0.1 M ethylenediaminetetraacetic acid. The filtrate was applied to a FumoniTest immunoaffinity column. Fumonisins were derivatized with naphthalene-2,3-dicarboxaldehyde, separated on a C(18) liquid chromatographic column, and detected by fluorescence. The detection

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.

John A Todd et al.

PLoS medicine, 13(10), e1002139-e1002139 (2016-10-12)

Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive CD4+ effector T cells (Teffs) to prevent autoimmune diseases

The primary structures of six human salivary acidic proline-rich proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f).

D I Hay et al.

The Biochemical journal, 255(1), 15-21 (1988-10-01)

Human glandular salivary secretions contain several acidic proline-rich phosphoproteins (PRPs). These proteins have important biological functions related to providing a protective environment for the teeth, and appear to possess other activities associated with modulation of adhesion of bacteria to oral

Determination of synthetic food dyes by capillary electrophoresis.

S Suzuki et al.

Journal of chromatography. A, 680(2), 541-547 (1994-10-07)

A method for the determination of synthetic tar dyes used as food additives using capillary electrophoresis with photodiode-array detection was investigated. The dyes Erythrosine (R-3), Phloxine (R-104), Rose Bengal (R-105), Acid Red (R-106), Amaranth (R-2), New Coccine (R-102) and Allura

Insulin modulates PC-1 processing and recruitment in cultured human cells.

C Menzaghi et al.

American journal of physiology. Endocrinology and metabolism, 284(3), E514-E520 (2002-11-21)

We evaluated whether insulin signaling modulates plasma cell glycoprotein (PC-1) plasma membrane recruitment, posttranslational processing, and gene expression in human cultured cell lines. Insulin induced a fourfold increase (P < 0.01) of membrane PC-1 expression by rapid and sensitive mechanism(s).

Page 1 of 4