Reaction design and optimization

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Inverse Electron Demand Diels–Alder Reactions of 1,2,4,5-Tetrazines and 1,2,3-Triazines

The inverse electron demand Diels-Alder reactions of electron-deficient heterocycles are significant cycloaddition reactions for the total synthesis of natural products containing highly substituted and functionalized heteroaromatic ring systems.

Scale-Up Guide: Suzuki-Miyaura Cross-Coupling Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form.

QuinoxP*

QuinoxP*: Air-Stable and Highly Efficient and Productive Chiral Ligands

Tetrakis(dimethylamino)ethylene (TDAE)

In 2001, Professor William Dolbier, Jr., at the University of Florida reported1 an approach to nucleophilic trifluoromethylation based on the generation of a trifluoromethyl anion using CF3I in the presence of a powerful twoelectron reductant, tetrakis(dimethylamino)ethylene (TDAE)

Solvent Stabilizer Systems

A description of stabilizer systems for solvents including esters, ethyl ester, tetrahydrofuran, chlorinated solvents, chloroform and dichloromethane.

Homobenzotetramisole (HBTM): A General Organocatalyst for Asymmetric Acylations

We are proud to offer the isothiourea organocatalyst homobenzotetramisole (HBTM) as part of our asymmetric catalysis portfolio in both (R) and (S) enantiomeric forms.

ChiPros Chiral Alcohols

Chiral alcohols form a versatile class of chiral synthons, since they can be incorporated into the API structures directly as esters or ethers.

Mild Mg – Halogen Exchange

Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.

Functionalized Silica Gels for Organic Synthesis

Functionalized silica gel is used in size-exclusion chromatography of cationic polymers and in the separation of sugars, steroids, cholesterol, and triglycerides.

BINOL and Derivatives

We present an article concerning BINOL and Derivatives.

Oxidizing and Reducing Agents

Oxidation and reduction reactions are some of the most common transformations encountered in organic synthesis

Phosgene and Phosgene Substitutes

Phosgene is 170 times more reactive than TP, the main phosgene substitute. Therefore, reactions with phosgene can be carried out under much milder conditions than with TP. Compounds will react faster and at lower temperatures (often at -78°C), preserving sensitive

Chiral Vicinal Diamines for Asymmetric Synthesis

Chiral vicinal diamines are of tremendous interest to the synthetic chemist as they are found in many chiral catalysts and pharmaceuticals.

Alkali Metal Silica Gels from SiGNa

SiGNa Chemistry has recently developed a technology for encapsulating alkali metals into nano-structured porous oxides to create stable, free flowing powders with varying reactivities (based on the intended application).

Chiral Amines in Asymmetric Synthesis

Chiral amines have found widespread application in asymmetric synthesis serving, for instance, as chiral bases in enantioselective deprotonation reactions or being valuable substances for resolving racemic mixtures of acids.

Trichloroacetimidate Reagents

Trichloroacetimidates are also commonly employed as alcohol alkylation reagents, particularly when existing functionality is not acid sensitive.

BINAP/SEGPHOS® Ligands and Complexes

We present an article concerning BINAP/SEGPHOS® Ligands and Complexes.

Selective Metalations

Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl

Asymmetric Transfer Hydrogenation

ChiPros Chiral Amines

Chiral amines play an important role in stereoselective organic synthesis. They are used directly as resolving agents, building blocks, or chiral auxiliaries.

Lithium Aminoborohydride (LAB) Reagents

Lithium aminoborohydride (LAB) reagents are a new class of powerful and selective reagents developed in the laboratory of Professor Bakthan Singaram at the University of California, Santa Cruz.

SyTracks Carbon Monoxide Generator FAQs

What is COgen? What is COware? What is the SyTracks COgenerator system? And more questions answered.

Greener Methods: Catalytic Amide Bond Formation

We are proud to offer a number of products used in catalytic amidation technology.

Baeyer-Villiger Oxidation Reaction

The Baeyer-Villiger oxidation is the oxidative cleavage of a carbon-carbon bond adjacent to a carbonyl, which converts the ketones to esters and the cyclic ketones to lactones.

Phosphazene Bases

Phosphazene base reagents are available as monomeric (P1 and BEMP), dimeric (P2), and tetrameric (P4) bases with different side chains to control their sterical hindrance.

Traditional Strong and Hindered Bases

The basicity strength for some of our traditional bases, including DBU, DBN, and n-BuL are listed for easy comparison.

Selective Metalation and Additions

Transformative reagents enable selective conversions within molecules containing sensitive functionalities under mild reactions.

Q-Phos

Q-Phos ligand by Professor Hartwig enables diverse C-N, C-O, and C-C bondforming reactions in coupling reactions.

Chiral Diene Ligands for Asymmetric Transformations

Chiral diene ligands enable asymmetric transformations, constructing enantioenriched compounds from achiral substrates efficiently.

Dess–Martin Periodinane

Dess-Martin Periodinane enables mild oxidation of alcohols to aldehydes and ketones suitable for synthesizing complex intermediates.

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