Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: perspectives for biomedical applications.

Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: perspectives for biomedical applications.

The FEBS journal (2013-11-14)

Sonia Melino, Celeste Santone, Paolo Di Nardo, Bibudhendra Sarkar

PMID24219363

ABSTRACT

Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability of histatins to inhibit collagenases and cysteine proteases, have attracted much attention for their potential use in the treatment of several oral diseases. This review critically assesses the studies carried out to date in order to provide a comprehensive and systematic vision of the information accumulated so far. In particular, the relationship between metal-binding and peptide activity is extensively analysed. The review provides important clues for developing possible therapeutic applications of histatins and their synthetic peptide analogues by creating a set of necessary resource materials to support investigators and industries interested in exploiting their unique properties.

MATERIALS

Product Number

Brand

Product Description

499552

Sigma-Aldrich

Zinc preparation, 5 g/dL Zn²⁺ in THF, highly reactive Rieke^®metal

349208

Sigma-Aldrich

Copper, foil, thickness 0.025 mm, 99.98% trace metals basis

349216

Sigma-Aldrich

Copper, wire, diam. 1.0 mm, ≥99.9%

326429

Sigma-Aldrich

Copper, wire, diam. 0.25 mm, 99.999% trace metals basis

326410

Sigma-Aldrich

Copper, wire, diam. 0.64 mm, 99.995% trace metals basis

349224

Sigma-Aldrich

Copper, wire, diam. 2.0 mm, 99.999% trace metals basis

GF84027988

Copper, tube, 500mm, outside diameter 4.0mm, inside diameter 3.2mm, wall thickness 0.4mm, as drawn, 99.9%

GF92248128

Copper - O.F.H.C., foil, 10m coil, thickness 0.1mm, coil width 100mm, hard, 99.95+%

GF94804779

Copper - O.F.H.C., foil, 50mm disks, thickness 0.25mm, half hard, 99.95+%

GF88138952

Copper - O.F.H.C., foil, 15mm disks, thickness 0.5mm, half hard, 99.95+%

GF69818855

Copper - O.F.H.C., foil, 50mm disks, thickness 0.05mm, hard, 99.95+%

GF95377911

Zinc, foil, 10mm disks, thickness 0.025mm, as rolled, 99.95+%

GF97770112

Zinc, foil, 15mm disks, thickness 0.005mm, 99.9%

GF71113823

Copper - O.F.H.C., foil, 50mm disks, thickness 0.5mm, half hard, 99.95+%

GF85011061

Copper - O.F.H.C., foil, 2m coil, thickness 0.125mm, hard, 99.95+%

GF97778558

Copper, wire reel, 500m, diameter 0.15mm, annealed, silver plated, 99.9%

GF84304177

Zinc, foil, 50x50mm, thickness 6mm, as rolled, 99.99+%

GF31119140

Zinc, foil, 300x300mm, thickness 0.35mm, as rolled, 99.95+%

GF66442428

Zinc, foil, 15mm disks, thickness 1.0mm, as rolled, 99.99+%

GF74488900

Copper, tube, 200mm, outside diameter 5.0mm, inside diameter 4mm, wall thickness 0.5mm, as drawn, 99.9%

GF84156262

Copper, tube, 500mm, outside diameter 1.75mm, inside diameter 0.33mm, wall thickness 0.71mm, as drawn, 99.9%

GF84372521

Copper, tube, 200mm, outside diameter 12.7mm, inside diameter 10.26mm, wall thickness 1.22mm, as drawn, 99.9%

GF82329172

Copper, tube, 200mm, outside diameter 0.95mm, inside diameter 0.29mm, wall thickness 0.33mm, as drawn, 99.9%

GF68687038

Copper - O.F.H.C., foil, 10m coil, thickness 0.1mm, hard, 99.95+%

GF93757786

Copper - O.F.H.C., foil, 15mm disks, thickness 0.125mm, hard, 99.95+%

GF87158650

Copper, tube, 500mm, outside diameter 1.0mm, inside diameter 0.24mm, wall thickness 0.38mm, as drawn, 99.9%

GF97918644

Copper - O.F.H.C., foil, 10m coil, thickness 0.125mm, hard, 99.95+%

GF69207240

Copper - O.F.H.C., foil, 10m coil, thickness 0.075mm, half hard, 99.95+%

GF98944600

Copper - O.F.H.C., foil, 25mm disks, thickness 0.025mm, hard, 99.95+%

GF93055901

Copper - O.F.H.C., foil, 2m coil, thickness 0.025mm, hard, 99.95+%