107700

4-(二甲氨基)吡啶

ReagentPlus^®, ≥99%

• Synonym(s): N,N-二甲基-4-吡啶胺, DMAP
• Empirical Formula (Hill Notation): C₇H₁₀N₂
• CAS Number: 1122-58-3
• Molecular Weight: 122.17
• Beilstein: 110354
• EC 号: 214-353-5
• MDL编号: MFCD00006418
• PubChem化学物质编号: 24846774
• NACRES: NA.22

Properties

• 质量水平: 200
• 产品线: ReagentPlus^®
• 测定: ≥99%
• 形式: chips; crystalline powder; flakes
• mp: 108-110 °C (lit.)
• 溶解性: H₂O: 50 mg/mL
• SMILES string: CN(C)c1ccncc1
• InChI: 1S/C7H10N2/c1-9(2)7-3-5-8-6-4-7/h3-6H,1-2H3
• InChI key: VHYFNPMBLIVWCW-UHFFFAOYSA-N

Description

一般描述

4-(Dimethylamino)pyridine is a highly versatile nucleophilic catalyst for acylation reactions and esterifications. It is also employed in various organic transformations like Baylis-Hillman reaction, Dakin-West reaction, protection of amines, C-acylations, silylations, applications in natural products chemistry, and many others.

应用

4-(Dimethylamino)pyridine can be used as a catalyst:

• To synthesize 3,5-disubstituted 2,6-dicyanoaniline by reacting malononitrile, aldehydes, and β-nitroolefins.
• For the acylation of alcohols with acid anhydrides under auxiliary base- and solvent-free conditions to synthesize corresponding esters.
• In Baylis-Hillman reaction to form carbon-carbon bond by the coupling of an activated alkene with an aldehyde or ketone.

酰化反应的高效催化剂

法律信息

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• 象形图: GHS05,GHS06,GHS08,GHS09
• 警示用语：: Danger
• 危险声明: H301 + H331 - H310 - H315 - H318 - H370 - H411
• 预防措施声明: P262 - P273 - P280 - P301 + P310 - P302 + P352 + P310 - P305 + P351 + P338
• 危险分类: Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 1
• 靶器官: Nervous system
• 储存分类代码: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 闪点(F): 255.2 °F
• 闪点(C): 124 °C
• 个人防护装备: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges