Merck
所有图片(1)

89095

Sigma-Aldrich

(R)-四氢糠醇

≥98.0% (sum of enantiomers, GC)

别名:
(R)-四氢呋喃甲醇
Empirical Formula (Hill Notation):
C5H10O2
CAS号:
分子量:
102.13
Beilstein:
79846
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

测定

≥98.0% (sum of enantiomers, GC)

形式

liquid

光学纯度

enantiomeric ratio: ≥97:3% (GC)

bp

178 °C (lit.)

密度

1.054 g/mL at 20 °C (lit.)

SMILES string

OC[C@H]1CCCO1

InChI

1S/C5H10O2/c6-4-5-2-1-3-7-5/h5-6H,1-4H2/t5-/m1/s1

InChI key

BSYVTEYKTMYBMK-RXMQYKEDSA-N

应用

(R)-Tetrahydrofurfuryl alcohol can be used:
  • To prepare (R)-tetrahydrofurfuryl aldehyde, which is employed as a building block to synthesize a fragment of pectenotoxin-4.
  • As a starting material to synthesize naftidrofuryl isomers, used as potent 5-hydroxytryptamine 2A receptor antagonists.
  • As a building block for the preparation of (S)-2-tetrahydrofuran methyl ether 6-fluorophenyl ether analog, as an IGF-1R inhibitor.

包装

1 g in glass bottle

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Eye Irrit. 2

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor
Hao J, et al.
Bioorganic & Medicinal Chemistry Letters, 22(10), 3441-3444 (2012)
Rhodium-catalysed vinyl 1, 4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
Richardson MSW, et al.
Chemical Science, 10(25), 6336-6340 (2019)
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors
Fairhurst RA, et al.
Bioorganic & medicinal chemistry letters, 26(8), 2057-2064 (2016)
[Acute poisoning with tetrahydrofurfuryl alcohol combined with methanol].
B F Murashov et al.
Voenno-meditsinskii zhurnal, (10)(10), 32-34 (1983-10-01)
T Schräder et al.
Journal of bacteriology, 183(24), 7408-7411 (2001-11-22)
Different aldehyde dehydrogenases (AlDHs) were formed during growth of Ralstonia eutropha Bo on tetrahydrofurfuryl alcohol (THFA). One of these enzymes, AlDH 4, was purified and characterized as a homodimer containing no prosthetic groups, showing a strong substrate inhibition, and having

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