Merck
所有图片(1)

P55805

Sigma-Aldrich

嘌呤

98%

别名:
7H-咪唑[4,5-d]嘧啶
Empirical Formula (Hill Notation):
C5H4N4
CAS号:
分子量:
120.11
Beilstein:
3200
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

100

测定

98%

形式

powder

mp

214-217 °C (lit.)

SMILES string

c1ncc2nc[nH]c2n1

InChI

1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)

InChI key

KDCGOANMDULRCW-UHFFFAOYSA-N

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一般描述

嘌呤是一种杂环有机化合物,由一个嘧啶环与一个咪唑环融合而成。

应用

在钯催化剂存在时,嘌呤可直接进行 C-H 功能化,形成各种生物学重要产品。

包装

1 g in glass bottle

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可以 PDF 形式 (P55805.pdf) 查看或下载。该中心的 METLIN 代谢物数据库中有测试代谢物。要了解更多信息,请访问 sigma.com/metlin。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

New developments in direct functionalization of C-H and N-H bonds of purine bases via metal catalyzed cross-coupling reactions.
Abdoli M, et al.
Royal Society of Chemistry Advances, 55(5), 44371-44389 (2015)
Benshang Li et al.
Nature medicine, 21(6), 563-571 (2015-05-12)
Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which
Silvia Meneghesso et al.
ChemMedChem, 8(3), 415-425 (2013-02-07)
2'-Fluoro-2'-deoxyguanosine has been reported to have potent anti-influenza virus activity in vitro and in vivo. Herein we describe the synthesis and biological evaluation of 6-modified 2'-fluoro-2'-deoxyguanosine analogues and their corresponding phosphoramidate ProTides as potential anti-influenza virus agents. Whereas the parent
Hiroshi Ashihara et al.
Phytochemistry, 69(4), 841-856 (2007-12-11)
Details of the recently elucidated biosynthetic pathways of caffeine and related purine alkaloids are reviewed. The main caffeine biosynthetic pathway is a sequence consisting of xanthosine-->7-methylxanthosine-->7-methylxanthine-->theobromine-->caffeine. Genes encoding N-methyltransferases involved in three of these four reactions have been isolated and
Kansuporn Sriyudthsak et al.
BMC systems biology, 8 Suppl 5, S4-S4 (2015-01-07)
Progress in systems biology offers sophisticated approaches toward a comprehensive understanding of biological systems. Yet, computational analyses are held back due to difficulties in determining suitable model parameter values from experimental data which naturally are subject to biological fluctuations. The

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