1.08307

高纯度三(羟甲基)胺基甲烷(氨基丁三醇)

(Trometamol) high purity, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JPC, USP

• 别名: 三（羟甲基）氨基甲烷, 2-氨基-2-(羟甲基)-1,3-丙二醇, THAM, Tris 碱, 氨基丁三醇
• 线性分子式: NH₂C(CH₂OH)₃
• 化学文摘社编号: 77-86-1
• 分子量: 121.14
• EC Index Number: 201-064-4
• UNSPSC Code: 12352209
• Beilstein/REAXYS Number: 741883
• MDL number: MFCD00004679

属性

• 产品名称: 高纯度三(羟甲基)胺基甲烷(氨基丁三醇), (Trometamol) high purity, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JPC, USP
• SMILES string: NC(CO)(CO)CO
• InChI: 1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
• InChI key: LENZDBCJOHFCAS-UHFFFAOYSA-N
• agency: BP; ChP; JPC; Ph. Eur.; USP
• vapor pressure: 0.0267 hPa ( 20 °C)
• description: EMPROVE^® EXPERT Ph Eur,BP,JPC,USP,ACS
• product line: EMPROVE^® EXPERT
• form: solid
• feature: RNase and DNase free
• pH: 10.2-10.6 (20 °C, 6 g/L in H₂O)
• useful pH range: 7-9
• pKa (25 °C): 8.1
• bp: 219-220 °C/10 mmHg (lit.); 219-220 °C/13.3 hPa
• mp: 167-172 °C (lit.)
• density: 1.35 g/cm³ at 23 °C
• application(s): liquid formulation; pharmaceutical; semi-solid formulation
• storage temp.: no temp limit
• Quality Level: 500

说明

Application

Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.
Due to its low polyoxymethylene limits, Tris(hydroxymethyl)aminomethane (Trometamol) Emprove^® Expert is suitable for use at elevated concentrations without risking precipitation. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 存储类别: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable