341006

EDAC，盐酸盐

EDAC HCl is a water-soluble derivative of carbodiimide useful for conjugating haptens to proteins and polypeptides. Used to modify NMDA receptors and as a condensing agent in peptide synthesis.

• 别名: EDAC，盐酸盐, EDCI，1-乙基-3-(3 ʹ-二甲基氨基丙基)碳二亚胺，HCl
• 经验公式（希尔记法）: C₈H₁₇N₃ · xHCl
• 化学文摘社编号: 25952-53-8
• 分子量: 155.24 (free base basis)
• UNSPSC Code: 41116133
• NACRES: NA.21
• MDL number: MFCD00012503

属性

• Quality Segment: 200
• description: RTECS - FF2200000
• assay: ≥98% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white
• solubility: aqueous buffer: 2-5 mg/mL, water: 2-5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Cl.N(CCCN(CC)C#N)(C)C
• InChI: 1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
• InChI key: FDXPUDRRFDHONO-UHFFFAOYSA-N

说明

General description

摩尔吸光系数（~212 nm；50 mM磷酸盐缓冲液，pH 8）：≥6800 M^-1cm^-1。

水溶性碳二亚胺衍生物。用于修饰NMDA受体。还可以用于将半抗原与蛋白质或多肽结合。

碳二亚胺的水溶性衍生物，可用于将半抗原与蛋白质和多肽结合。用于修饰NMDA受体，并在肽合成中用作缩合剂。EDAC偶联的主要优势在于可通过用稀酸或水洗涤而轻松去除过量的试剂和相应的尿素。碳二亚胺可通过活化羧酸酯以形成O-酰脲来催化酰胺键、羧酸和胺的形成。该中间体可被胺直接攻击以形成酰胺。EDAC作为可溶性尿素衍生物而被释放。

Packaging

用惰性气体包装

Preparation Note

溶液中不稳定。仅在使用前进行重悬。

避免使用含有胺的缓冲液。

Other Notes

Chazot, P.L., et al. 1993.生物化学。Pharmacol.45, 605.
Richardson, A., et al. 1992.生物化学。Pharmacol.43, 1415.
Taniuchi, M., et al. 1986.《美国Natl.Acad.Sci. USA83, 1950.
Chase, J.W., et al. 1983.Proc.Natl.Acad.Sci. USA80, 5480.
Williams, A., et al. 1981.J. Am. Chem. Soc.103, 7090.
Yamada, H., et al. 1981.Biochemistry20, 4836.
Thomas, J.O., et al. 1978.J. Mol.Biol.123, 149.
Ozawa, H. 1970.Biochemistry9, 2158.
Kopple, K.D., et al. 1962.J. Am. Chem. Soc.84, 4457.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：刺激性（B）

安全信息

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• target_organs: Stomach,large intestine,lymph node
• 存储类别: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• hcodes: H302,H311,H315,H317,H319,H373,H410
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral