8.08260

三氟乙酸

for synthesis

• Synonym(s): TFA
• Linear Formula: CF₃COOH
• CAS Number: 76-05-1
• Molecular Weight: 114.02
• Beilstein: 742035
• MDL编号: MFCD00004169
• EC索引号: 200-929-3

Properties

• 蒸汽密度: 3.9 (vs air)
• 质量水平: 200
• 蒸汽压: 97.5 mmHg ( 20 °C)
• 测定: ≥99% (acidimetric)
• 形式: liquid
• 折射率: n20/D 1.3 (lit.)
• pH值（酸碱度）: 1 (10 g/L in H₂O)
• bp: 72.4 °C (lit.)
• mp: −15.4 °C (lit.)
• 溶解性: soluble 10 g/mL
• 密度: 1.489 g/mL at 20 °C (lit.)
• 储存温度: 2-30°C
• SMILES string: OC(C(F)(F)F)=O
• InChI: 1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: DTQVDTLACAAQTR-UHFFFAOYSA-N

Description

一般描述

Trifluoroacetic acid is widely used in organic synthesis as a solvent, catalyst and reagent. It is a strong acid and low boiling point reagent. It can be used as a catalyst for a variety of reactions such as rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations.

应用

Trifluoroacetic acid can be used as a catalyst

• In the direct conversion of cyclohexanone to caprolactam using acetonitrile as the additive.
• In the synthesis of 1,2,4,5-tetrasubstituted imidazoles by four-component condensation of benzil, aldehydes, amines, and ammonium acetate.

Trifluoroacetic acid can also be used

• In the synthesis of d-α-Tterpineo from d-limonene by Markovnikov addition followed by hydrolysis.

包装

1 l in Glass bottle

25 , 500 ml in Glass bottle

2.5 l

100 ml

25 kg in Barrel PE/met

特点和优势

Trifluoroacetic acid can be used as a catalyst due to its

• High acidity
• Easy elimination
• Good solubility in organic solvent and in water.

分析说明

含量测定（酸量法）： ≥ 99.0 %
密度（d 20 °C/4 °C）：1.487 - 1.490
鉴别（IR）：符合检验

Safety Information

• 象形图: GHS05,GHS07
• 警示用语：: Danger
• 危险声明: H314 - H332 - H412
• 预防措施声明: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危险分类: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• 储存分类代码: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 2
• 闪点(F): 212.0 °F - Pensky-Martens closed cup
• 闪点(C): > 100 °C - Pensky-Martens closed cup