Merck
All Photos(1)

27285

Sigma-Aldrich

乙二胺四乙酸 二钠盐 二水合物

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

Synonym(s):
EDTA 二钠盐, EDTA-Na2, 乙二胺四乙酸二钠 二水合物, 依地酸, 依地酸二钠, 依地酸盐 二钠盐 二水合物
Empirical Formula (Hill Notation):
C10H14N2Na2O8 · 2H2O
CAS Number:
Molecular Weight:
372.24
Beilstein:
3900609
EC 号:
PubChem化学物质编号:
NACRES:
NA.77

Agency

tested according to BP
tested according to Ph. Eur.
tested according to USP

质量水平

200

reg. compliance

tested according to FCC

测定

99.0-101.0%

质量

meets analytical specification of Ph. Eur., BP, USP, FCC

杂质

residual solvents, complies
≤0.001% cyanide (CN)
≤0.001% heavy metals (as Pb)
≤0.1% nitrilotriacetic acid (HPLC) (HPLC)

缺失

8.7-11.4% loss on drying, 200 °C, 3 h

pH值(酸碱度)

4-5 (20 °C, 5%)

mp

248 °C (dec.) (lit.)

溶解性

water: soluble 100 g/L at 20 °C

痕量阴离子

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg

痕量阳离子

As: ≤1 mg/kg
Ca:, in accordance
Fe: ≤10 mg/kg
Pb: ≤10 mg/kg

application(s)

pharmaceutical (small molecule)

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

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应用

乙二胺四乙酸二钠盐二水合物与 Na2HPO4 和柠檬酸一起用于制备 Na2EDTA-McIlvaine 缓冲液。乙二胺四乙酸二钠盐二水合物的水溶液也已用于光催化制氢
二价阳离子的螯合剂。抑制需要二价阳离子才能具有活性的酶,例如金属蛋白酶。

生化/生理作用

乙二胺四乙酸二钠盐二水合物是广泛使用的二价阳离子如 Ca+2 的螯合剂,并抑制金属离子依赖性蛋白酶,如钙依赖性半胱氨酸蛋白酶。EDTA 还可作为金属蛋白酶活性位点中锌离子的螯合剂;因此它抑制了需要锌来活化的金属蛋白酶。另外,EDTA 可防止血小板聚集,并且是血小板计数的优选抗凝血剂。

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Inhalation - STOT RE 2 Inhalation

靶器官

Respiratory Tract

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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