Merck

410225

Sigma-Aldrich

甘氨酸

ACS reagent, ≥98.5%

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别名:
氨基乙酸, 甘氨酸
线性分子式:
NH2CH2COOH
CAS号:
分子量:
75.07
Beilstein:
635782
EC 号:
MDL编号:
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.21

等级

ACS reagent

质量水平

检测方案

≥98.5%

形式

powder, crystals or granules

杂质

H2SO4, passes test (darkened)
Hydrolyzable subsances, passes test

灼烧残渣

≤0.1%

颜色

white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

痕量阴离子

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.005%

痕量阳离子

NH4+: ≤0.005%
heavy metals: ≤0.002% (by ICP)

application(s)

peptide synthesis

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

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此商品
5004615527G8790
Glycine ACS reagent, ≥98.5%

Sigma-Aldrich

410225

甘氨酸

-
Glycine BioUltra, for molecular biology, ≥99.0% (NT)

Sigma-Aldrich

50046

甘氨酸

Premium Grade
Glycine meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

Sigma-Aldrich

15527

甘氨酸

Essential Grade
Glycine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5%

Sigma-Aldrich

G8790

甘氨酸

-
assay

≥98.5%

assay

≥99.0% (NT)

assay

99-101% (based on anhydrous substance)

assay

≥98.5%

form

powder, crystals or granules

form

crystalline

form

crystalline powder

form

powder

impurities

H2SO4, passes test (darkened), Hydrolyzable subsances, passes test

impurities

DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected

impurities

hydrolyzable substances, complies, organic volatile impurities, complies (GC), residual solvents, complies, ≤0.001% heavy metals (as Pb), ≤1.0% ninhydrin-positive substances

impurities

endotoxin, tested

color

white

color

white

color

white

color

white

mp

240 °C (dec.) (lit.)

mp

240 °C (dec.) (lit.)

mp

240 °C (dec.) (lit.)

mp

240 °C (dec.) (lit.)

应用

甘氨酸用于全细胞膜片钳记录,以测量NMDA(N-甲基-D-天冬氨酸)内向电流。它还用作结晶学中的模型有机系统,展示新型声学雾化平台。

生化/生理作用

甘氨酸是非必需氨基酸。通过细胞膜的钙内流由甘氨酸门控通道介导。甘氨酸参与卟啉、嘌呤和丝氨酸的合成。它还可作为谷氨酸与NMDA(N-甲基-D-天冬氨酸)受体结合的竞争性激动剂。在快速增殖的癌细胞中,由于对氨基酸的需求增加,甘氨酸合成可能会增加。
脊髓中的抑制性神经递质,NMDA受体的变构调节器。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Glycine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5%

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甘氨酸

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甘氨酸 盐酸盐

A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
Heba Ahmed
Advanced Materials, 30(3) (2018)
Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View
Vinita Jagannath
Frontiers in Molecular Neuroscience (2017)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1), 1-17 (2009)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

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