Merck
All Photos(1)

46401

Supelco

环己酰亚胺,大包装

PESTANAL®, analytical standard

Synonym(s):
3- [2-(3,5-二甲基-2-氧代环己基)-2-羟乙基]戊二酰亚胺, 放线菌酮, 纳拉霉素A
Empirical Formula (Hill Notation):
C15H23NO4
CAS Number:
Molecular Weight:
281.35
Beilstein:
88868
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

质量水平

100

描述

mixture of stereo isomers

产品线

PESTANAL®

测定

≥95% (HPLC)

保质期

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

溶解性

H2O: slightly soluble

抗生素抗菌谱

fungi

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care

格式

neat

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES string

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

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一般描述

Cycloheximide is an antibiotic having significant antifungal properties. It is produced by streptomycin-producing strains of Streptomyces griseus and acts by inhibiting protein synthesis. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. It is used as a fungicide.
As per Regulation (EC) No 1107/2009, repealing the directive 91/414, cycloheximide is not approved for use in the European Union (EU).

应用

Cycloheximide may find the following uses:
  • To evaluate the antifungal efficacy and safety of cycloheximide as a supplement in Optisol-GS
  • To study the effect of cycloheximide on leaf-cutting ant workers
  • To study the effect of streptomycin, cycloheximide, fungizone, captan, carbofuran, cygon, and pentachloronitrobenzene on soil microorganisms
  • To study the fungal control of nitrous oxide production in a semiarid grassland
  • To study the activity and degradation of streptomycin and cycloheximide in soil

生化/生理作用

环己酰亚胺(CHX)是由灰链霉菌产生的一种抗生素。它的主要生物学活性是真核生物中的翻译抑制,从而导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。

法律信息

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

警示用语:

Danger

危险分类

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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