所有图片(1)

47673

Sigma-Aldrich

甲醛 溶液

tested according to Ph. Eur.

别名:
福尔马林, 35% 甲醛溶液
线性分子式:
HCHO
CAS号:
分子量:
30.03
Beilstein:
1209228
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

质量水平

200

机构/方法

USP/NF
tested according to Ph. Eur.

蒸汽密度

1.03 (vs air)

蒸汽压

52 mmHg ( 37 °C)

自燃温度

572 °F

包含

9.0-15.0 % (v/v) methanol as stabilizer

浓度

25-50%

溶解性

water: soluble

密度

1.09 g/mL at 25 °C (lit.)

适用性

suitable for manufacturing use (Laboratory chemicals)

SMILES string

[H]C([H])=O

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

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应用

在流式细胞术中,甲醛溶液已被用于固定标记的细胞。

生化/生理作用

甲醛是最简单的醛,其可使RNA的双螺旋区域变性并将多核苷酸转化为无规卷曲。 它是一种遗传毒性物质,可显著诱导DNA-蛋白质交联(DPC)、姐妹染色单体交换、微核形成并导致细胞毒性。 它还在大鼠的鼻上皮中诱导肿瘤并且被认为是人类致癌物。

注意

储存时可能变混浊

警示用语:

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1 - STOT SE 3

靶器官

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 3

闪点(F)

133.0 °F - closed cup

闪点(C)

56.11 °C - closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

分析证书

原产地证书 (CofO)

Dependence of the sedimentation coefficient on molecular weight of RNA after reaction with formaldehyde.
H Boedtker
Journal of molecular biology, 35(1), 61-70 (1968-07-14)
J L Wilson et al.
Journal of immunology (Baltimore, Md. : 1950), 163(12), 6365-6370 (1999-12-10)
NK cells have the capacity to spontaneously kill tumor cell lines, in particular cell lines of hemopoietic origin. In contrast, they do not generally kill nontransformed autologous cells. However, here we demonstrate that short-term activated polyclonal human NK cells, as...
O Merk et al.
Environmental and molecular mutagenesis, 32(3), 260-268 (1998-11-14)
Formaldehyde (FA) is a genotoxic substance, induces tumors in the nasal epithelium of rats, and is suspected to be a human carcinogen. As a primary DNA lesion, FA induces DNA-protein crosslinks (DPC) and the formation of DPC has been used...
Cindy S Ma et al.
The Journal of experimental medicine, 205(7), 1551-1557 (2008-07-02)
Hyper-immunoglobulin E syndrome (HIES) is a primary immune deficiency characterized by abnormal and devastating susceptibility to a narrow spectrum of infections, most commonly Staphylococcus aureus and Candida albicans. Recent investigations have identified mutations in STAT3 in the majority of HIES...
G R Moore et al.
Neurology, 55(10), 1506-1510 (2000-11-30)
To determine the pathologic basis of areas not exhibiting signal of the short-T2 component of the T2 relaxation distribution in MS, as studied in formalin-fixed brain. A myelin-specific MRI signal would be of great importance in assessing demyelination in patients...

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