Merck
All Photos(2)

E3893

Sigma-Aldrich

(−)-表儿茶素没食子酸酯

≥98% (HPLC), from green tea

Synonym(s):
(-)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, (-)-cis-3,3′,4′,5,7-Pentahydroxyflavane 3-gallate, 3- O -没食子酰表儿茶精
Empirical Formula (Hill Notation):
C22H18O10
CAS Number:
Molecular Weight:
442.37
MDL编号:
PubChem化学物质编号:
NACRES:
NA.21

生物来源

green tea

质量水平

检测方案

≥98% (HPLC)

储存温度

2-8°C

SMILES string

Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4ccc(O)c(O)c4

InChI

1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21-/m1/s1

Inchi Key

LSHVYAFMTMFKBA-TZIWHRDSSA-N

Gene Information

human ... CYP1A2(1544)

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(−)-Epicatechin ≥98% (HPLC), from green tea

Sigma-Aldrich

E4018

(−)-表儿茶素

assay

≥98% (HPLC)

assay

≥80% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

biological source

green tea

biological source

green tea

biological source

green tea

biological source

green tea

Gene Information

human ... CYP1A2(1544)

Gene Information

human ... CYP1A2(1544)

Gene Information

human ... BACE1(23621), CYP1A2(1544)

Gene Information

-

一般描述

(−)-表儿茶素没食子酸酯是绿茶的主要多酚成分之一,属于儿茶素没食子酸酯类有机化合物。ECG的化学结构与绿茶中的另一种主要多酚(−)-表没食子儿茶素没食子酸酯(EGCG)相似。

应用

(−)-表儿茶素没食子酸酯已用于:
  • 通过人脑微血管内皮细胞(HBMVEC)的增殖检测,了解其抗缺血再灌注损伤的有效性
  • 作为人唾液α-淀粉酶(HAS)和α-葡萄糖苷酶(AGH)抑制检测的抑制剂
  • 可用作人结直肠细胞系HCT-116和SW-480的多酚类癌症化学预防药物
  • 作为胶原酶和弹性蛋白酶的体外抑制剂
  • 作为精子培育的添加剂,验证其抗氧化应激作用的有效性

生化/生理作用

(−)-表儿茶素没食子酸酯(ECG)是强效的自由基清除剂,因对胶原蛋白和弹性蛋白酶具有抑制作用而可用作抗老化剂。它对人结直肠细胞具有抗增殖作用,因而可用作化学预防药物。它影响细胞生存,可通过促进氧糖剥夺的人脑微血管内皮细胞的增殖,防止细胞凋亡或自噬。ECG在结构与功能上都与EGCG类似,可参与内质网应激中哺乳动物雷帕霉素靶蛋白(mTOR)-AMP激活蛋白激酶(AMPK)通路的平衡。它在这种情况下可抵抗氧剥夺造成的细胞损伤,从而防止细胞死亡。ECG可参与防止氧化应激。它可有效抑制多种疾病状态下的分泌性鞘磷脂酶作用,并在辅助生殖技术(ART)中为人类精子提供保护。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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