PHR1105

Supelco

L-亮氨酸

Pharmaceutical Secondary Standard; Certified Reference Material

别名:
(S)-2-氨基-4-甲基戊酸
线性分子式:
(CH3)2CHCH2CH(NH2)CO2H
CAS号:
分子量:
131.17
Beilstein/REAXYS Number:
1721722
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

形式

neat

CofA

current certificate can be downloaded

应用

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (lit.)

特色行业

Pharmaceutical (small molecule)

格式

neat

药典可追溯性

traceable to PhEur L0375000
traceable to USP 1357001

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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一般描述

亮氨酸是一种非生糖必需氨基酸,是蛋白质的一种结构性成分。
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
L-亮氨酸可用作高效液相色谱技术定量检测药物制剂中分析物的药物参考标准品。

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

该认证参考物质(CRM)根据 ISO 17034ISO/IEC 17025进行生产和认证。所有关于客户关系管理的信息都可以在分析证书上找到。

附注

要查看该材料的分析证书示例,请在下方栏位输入 LRAA6929。这只是一个示例证书,可能不是您收到的批次。

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

HPLC-fluorescence determination of amino acids in pharmaceuticals after pre-column derivatization with phanquinone
Gatti.R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 35(2), 339-348 (2004)
William I A Haynes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4804-4814 (2013-03-15)
The identification of a hyperdirect cortico-subthalamic nucleus connection highlighted the important role of the subthalamic nucleus (STN) in regulating behavior. However, this pathway was shown primarily from motor areas. Hyperdirect pathways associated with cognitive and motivational cortical regions are particularly...
Qian Wang et al.
Journal of the National Cancer Institute, 105(19), 1463-1473 (2013-09-21)
L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and protein synthesis. LAT1 and LAT3 are overexpressed at different stages of prostate cancer, and they are responsible for...
M Sakamoto et al.
The Journal of clinical endocrinology and metabolism, 56(1), 202-204 (1983-01-01)
Recent studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin from bovine adrenal medulla and human pheochromocytoma have revealed that this precursor molecule contains four copies of methionine-enkephalin (Met-Enk) and one copy each of leucine-enkephalin (Leu-Enk)...
T Yoshimasa et al.
The Journal of clinical investigation, 69(3), 643-650 (1982-03-01)
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with...
实验方案
Separation of L-Alanine; Glycine; L-Valine; L-Leucine; L-Isoleucine; L-Proline; L-Methionine; L-Serine; L-Threonine; L-Phenylalanine; L-Aspartic acid; L-4-Hydroxyproline; L-Cysteine; L-Glutamic acid; L-Asparagine; L-Lysine; L-Glutamine; L-Histidine; L-Tyrosine; L-Tryptophan; L-Cystine
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