所有图片(1)

S0900000

牛胆酸钠

BRP, European Pharmacopoeia (EP) Reference Standard

别名:
牛磺胆酸 钠盐
Empirical Formula (Hill Notation):
C26H44NNaO7S
CAS号:
分子量:
537.68
Beilstein:
3901620
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

形式

neat

特色行业

Pharmaceutical (small molecule)

格式

neat

InChI

1S/C26H45NO7S.Na.H/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1

InChI key

VXRNGJZKPMKERN-NEMAEHQESA-N

一般描述

本产品按照现行药典要求提供和指定。所有为支持本产品而提供的信息,包括 SDS 和任何产品信息小册子,均由药典颁发机构制定和发布。如需进一步的信息和支持,请访问现行药典网站。 如需进一步信息和支持,请访问现行药典网站。

应用

用于蛋白质溶解的阴离子洗涤剂。

生化/生理作用

非硫酸化胆汁盐,具有转运胆盐输出泵/Pgp 姐妹蛋白(BSEP/spgp)的底物、Na(+)/牛磺胆酸盐协同转运蛋白(NTCP)和 MRP3 进入进入肝脏的生理功能。

包装

单位数量:10000 mg。随时可能改变。产品按照发行药典的规定交付。有关当前单位数量,请访问EDQM对照品目录

注意

其他说明

可能适用相应的销售限制。

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Jean-Louis Delaunay et al.
Hepatology (Baltimore, Md.), 65(2), 560-570 (2016-12-25)
ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Variations in the ABCB4 gene are responsible for several biliary diseases, including progressive familial intrahepatic cholestasis type...
Xiao-Xia Fang et al.
Electrophoresis, 37(17-18), 2376-2383 (2016-07-06)
Here, a compact high-speed CE bioanalyzer based on a short capillary has been developed. Multiple modules of picoliter scale sample injection, high-speed CE separation, sample changing, LIF detection, as well as a custom designed tablet computer for data processing, instrument...
Philipp Uhl et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 108, 111-118 (2017-07-19)
Despite the outstanding progress in modern medicine, the oral delivery of peptide drugs is limited until today due to their instability in the gastrointestinal tract and low mucosa penetration. To overcome these hurdles, liposomes containing the specific tetraether lipid GCTE...
Takashi Yoshikado et al.
Molecular pharmacology, 83(2), 552-562 (2012-12-12)
The antiplatelet drug, ticlopidine (TIC), reportedly causes cholestatic liver injuries. The present study analyzed the effect of TIC on bile formation, revealing that the biliary secretion of phospholipids was significantly decreased in TIC-administered Sprague Dawley (SD) rats. However, the effect...
Philip C Christophersen et al.
Journal of controlled release : official journal of the Controlled Release Society, 197, 111-120 (2014-12-03)
The aim of this study was to gain new insights into protein distribution in solid lipid microparticles (SLMs) and subsequent release mechanisms using a novel label-free chemical imaging method, coherent anti-Stokes Raman scattering (CARS) microscopy. Lysozyme-loaded SLMs were prepared using...

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