Merck
所有图片(1)

15862

Sigma-Aldrich

0.1 M 氯化钴 溶液

别名:
氯化钴 溶液, 添加剂筛查溶液 24/试剂盒-No 78374
CAS号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

质量水平

100

密度

1.01 g/mL at 20 °C

储存温度

2-8°C

SMILES string

Cl[Co]Cl

InChI

1S/2ClH.Co/h2*1H;/q;;+2/p-2

InChI key

GVPFVAHMJGGAJG-UHFFFAOYSA-L

应用

0.1M 氯化钴溶液已被用于模拟前列腺癌细胞的低氧暴露和 HIF-1(缺氧诱导因子 1)的表达。其已用于诱导人肠上皮细胞缺氧。

生化/生理作用

氯化钴通过上调缺氧诱导因子-1α 诱导细胞缺氧 (HIF-1α)、促红细胞生成素和糖酵解酶。它也是大鼠神经元 PC12 细胞线粒体 DNA 损伤的原因。其也负责诱导细胞凋亡。
0.1M 氯化钴溶液是添加剂筛选试剂盒的添加剂筛选液。添加剂筛选试剂盒设计用于快速方便地评价添加剂及其影响样品结晶的能力。添加剂试剂盒为精制结晶条件提供了工具。

象形图

Health hazardEnvironment

警示用语:

Danger

危险分类

Aquatic Chronic 2 - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析证书

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原产地证书 (CofO)

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更多文件

Quotes and Ordering

CoCl(2) induces apoptosis via the 18 kDa translocator protein in U118MG human glioblastoma cells.
Zeno S, et al.
Biochemistry, 48, 4652-4652 (2009)
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Wang G, et al.
Nucleic Acids Research, 28, 2135-2135 (2000)
Francesca Lazzara et al.
Frontiers in pharmacology, 11, 1063-1063 (2020-08-28)
Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial
Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans.
Wojtal KA, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 307, G673-G673 (2014)
Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells.
Hennessey D, et al.
Urologic Oncology, 31, 1106-1106 (2013)

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