Merck
所有图片(1)

30960

Sigma-Aldrich

脱氧胆酸

≥99.0% (T)

别名:
7-脱氧胆酸, 脱氧胆酸, 3α,12α-二羟基-5β-胆汁酸
Empirical Formula (Hill Notation):
C24H40O4
CAS号:
分子量:
392.57
Beilstein:
3219882
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

生物来源

ox bile

描述

anionic

测定

≥99.0% (T)

形式

powder

旋光性

[α]20/D +54±1°, c = 1% in ethanol

分子量

392.57 g/mol

杂质

≤1% cholic acid (TLC)

mp

170-175 °C
171-174 °C (lit.)

官能团

carboxylic acid

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

InChI key

KXGVEGMKQFWNSR-LLQZFEROSA-N

Gene Information

human ... ATIC(471)

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一般描述

脱氧胆酸是一种两亲分子,是胆汁酸的重要组成部分。它包括3α和12α位取代的羟基和支链末端的羧基。这些组成成分可对分子的亲水性产生影响并且疏水环戊烯并菲形成其中心。

应用

使用脱氧胆酸用作:
  • 体外测定中的菌丝抑制化合物,以研究胃肠道中白色念珠菌的菌丝形态发生
  • 一种用于估计细胞团块中毒素浓度的内部标准品
  • 采用超高效液相色谱三重四极杆质谱联用技术定量在接受治疗的小鼠各种样品中定量测定BA的胆汁酸(BA)颗粒

生化/生理作用

脱氧胆酸的两亲性特性可显著有助于溶解、乳化和吸收体内的脂肪、维生素和胆固醇等。肠内脱氧胆酸含量高可通过诱导氧化应激和DNA损伤导致结肠直肠癌。它是一种致癌和促肿瘤因子。

其他说明

用于β-肾上腺素能受体的增溶

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Acute Tox. 4 Oral

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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更多文件

Quotes and Ordering

Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates
Wang F, et al.
Carbohydrate Polymers, 84, 1192-1200 (2011)
E Nedivi et al.
The Journal of biological chemistry, 259(9), 5803-5808 (1984-05-10)
Agonist, but not antagonist, protects the beta-adrenergic receptor from inactivation during solubilization in deoxycholate. Protection is apparently due to locking of the agonist in the receptor, a high affinity interaction induced or stabilized by this detergent. The guanyl nucleotide-binding protein
Jeffery L Smith et al.
Hepatology (Baltimore, Md.), 39(6), 1673-1682 (2004-06-09)
Focal biliary cirrhosis causes significant morbidity and mortality in cystic fibrosis (CF). Although the mechanisms of pathogenesis remain unclear, bile acids have been proposed as potential mediators of liver injury. This study examined bile acid composition in CF and assessed
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
Shin Yoshimoto et al.
Nature, 499(7456), 97-101 (2013-06-28)
Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating

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