Merck

88635

Sigma-Aldrich

5-硫基-D-葡萄糖

≥98.0% (HPLC)

Empirical Formula (Hill Notation):
C6H12O5S
CAS号:
分子量:
196.22
Beilstein:
1865193
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

质量水平

检测方案

≥98.0% (HPLC)

形式

powder

旋光性

[α]/D 220.0±5.0°, c = 1 in 0.1 M HCl

颜色

white to off-white

mp

135-138 °C (lit.)

SMILES string

OC[C@H]1S[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1

InChI key

KNWYARBAEIMVMZ-DVKNGEFBSA-N

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此商品
G08869232016555
5-Thio-D-glucose ≥98.0% (HPLC)

Sigma-Aldrich

88635

5-硫基-D-葡萄糖

form

powder

form

powder

form

powder

form

powder or crystals

color

white to off-white

color

white to off-white

color

-

color

-

mp

135-138 °C (lit.)

mp

-

mp

-

mp

-

optical activity

[α]/D 220.0±5.0°, c = 1 in 0.1 M HCl

optical activity

[α]/D 24.00 to 30.00°, c = 9.00-11.00 mg/mL in water

optical activity

[α]/D -24.0±2.0, c = 1% (w/v) in water

optical activity

[α]/D 135.0±5.0°, c = 1 in DMF/H2O 1:1

应用

5-硫-D-葡萄糖(Glc-5S),一种硫糖己糖激酶抑制剂,可用于在体内控制/降低糖酵解的速率。

生化/生理作用

D-葡萄糖的细胞运输和D-葡萄糖介导的胰岛素释放的有效竞争性抑制剂。 精子生成抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Xiaoyin Wu et al.
Journal of neurophysiology, 91(4), 1734-1747 (2003-12-03)
Circulating glucose levels significantly affect vagal neural activity, which is important in the regulation of pancreatic functions. Little is known about the mechanisms involved. This study investigates the neural pathways responsible for hypoglycemia-induced vagal efferent signaling to the pancreas and
Studies on oxidative phosphorylation. XVI. Sulfhydryl involvement in the energy-transfer pathway.
C K Kurup et al.
Biochemistry, 7(12), 4483-4491 (1968-12-01)
I Tahirovic et al.
Journal of neural transmission. Supplementum, (72)(72), 235-240 (2007-11-07)
It is believed that oxidative stress plays a central role in the pathogenesis of metabolic diseases like diabetes mellitus (DM) and its complications (like peripheral neuropathy) as well as in neurodegenerative disorders like sporadic Alzheimer's disease (sAD). Representative experimental models
The pancreatic beta-cell recognition of insulin secretagogues. 3. Effects of substituting sulphur for oxygen in the D-glucose molecule.
B Hellman et al.
Biochemical pharmacology, 22(1), 29-35 (1973-01-01)
Role of the binuclear manganese(II) site in xylose isomerase.
R Bogumil et al.
Metal ions in biological systems, 37, 365-405 (2000-02-29)

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