A1653

白蛋白 来源于人类血清

lyophilized powder, ≥96% (agarose gel electrophoresis)

• Synonym(s): HSA
• CAS Number: 70024-90-7
• EC 号: 274-272-6
• MDL编号: MFCD00081418
• eCl@ss: 42010201
• NACRES: NA.25

Properties

• 生物来源: human
• 质量水平: 300
• 测定: ≥96% (agarose gel electrophoresis)
• 形式: lyophilized powder
• 分子量: monomer calculated mol wt 66478 Da
• technique(s): ELISA: suitable; tissue culture: suitable; western blot: suitable
• 杂质: HIV I and HIVII, HCV and HBsAg, tested negative
• 溶解性: H₂O: soluble 50 mg/mL
• UniProt登记号: P02768
• 储存温度: 2-8°C
• Gene Information: human ... ALB(213)

Description

一般描述

Albumin (ALB) constitutes 25% of the proteins produced by the liver.[1] It is a protein of a single polypeptide chain with a thiol group.[2] The ALB gene is mapped to human 4q13.3.[3]

应用

白蛋白用于测试其对头孢托仑对耐青霉素的肺炎链球菌的体外杀菌活性的影响。[4]
它已在临床上用于严重和经常危及生命的情况，例如由于外伤、烧伤和手术引起的休克和失血。[5]

Albumin from human serum has been used:

• in cyclophilin isomerase assay[6]
• as a component in blocking solution for immunogold quantification of amino acids and proteins in complex subcellular compartments[7]
• in G-pseudotyped HIV (PHIV) assay mixture to study its effect on GSK364735 antiviral potency[8]

包装

500 mg in poly bottle

1, 5, 10, 50, 100 g in poly bottle

生化/生理作用

血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白，对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质，特别是药物（例如布洛芬、华法林），并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。

Albumin serves as a protein repository and functions as a binding and transport protein. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This prevents the loss of substance through excretion.[9] Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia.[1]

质量

其余大部分为球蛋白

其他说明

更多信息参见人血清白蛋白。

Safety Information

• 储存分类代码: 13 - Non Combustible Solids
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable
• 个人防护装备: Eyeshields, Gloves