Merck
所有图片(1)

A2129

Sigma-Aldrich

γ-氨基丁酸

≥99%

别名:
4-氨基丁酸, 氨酪酸, ]γ-氨酪酸, 3-羧丙胺, GABA, 哌啶酸
线性分子式:
NH2(CH2)3COOH
CAS号:
分子量:
103.12
Beilstein:
906818
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

质量水平

200

测定

≥99%

形式

crystals

mp

195 °C (dec.) (lit.)

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

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应用

γ-氨基丁酸(GABA)用于:
  • 制备GABA-BSA(牛血清蛋白)-GA(戊二醛)复合物,用于GABA免疫染色对照。
  • 核磁共振(MRS)高分子抑制检测。
  • GABA肠内给药,降低管腔内液体分泌

生化/生理作用

GABA(γ-氨基丁酸)是一种氨基酸,作为中枢神经系统中的抑制性神经递质,在外周组织中也可用作神经调节剂。其可与GABAA受体结合,抑制信号接收神经活性。GABAA受体能够在神经细胞细胞膜形成通道。一旦和GABA结合,受体被激活,允许带负电的分子,比如氯离子通过通道,进入细胞。这会降低细胞兴奋度。
GABA能神经元参与肌肉松弛,抗焦虑治疗,镇静和麻醉。GABA也可以影响心率和血压。
大脑中的主要抑制性神经递质;GABAA 和 GABAB 受体激动剂;增加 Cl 的传导性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书

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原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

Isabelle Niespodziany et al.
Epilepsia, 61(5), 914-923 (2020-04-17)
The antiepileptic drug candidate, padsevonil, is the first in a novel class of drugs designed to interact with both presynaptic and postsynaptic therapeutic targets: synaptic vesicle 2 proteins and γ-aminobutyric acid type A receptors (GABAA Rs), respectively. Functional aspects of
Yan Li et al.
American journal of physiology. Gastrointestinal and liver physiology, 303(4), G453-G460 (2012-06-16)
γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, and it is produced via the enzymatic activity of glutamic acid decarboxylase (GAD). GABA generates fast biological signaling through type A receptors (GABA(A)R), an anionic channel. Intriguingly
S J Mihic et al.
Alcohol health and research world, 21(2), 127-131 (1997-01-01)
The neurotransmitter gamma-aminobutyric acid (GABA) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells. The GABAA receptor is a channel-forming protein that allows the passage of chloride ions into the cells. Excessive GABAA activation
R Fabian-Fine et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(1), 298-310 (1998-12-31)
The mechanosensory organs of arachnids receive diverse peripheral inputs. Little is known about the origin, distribution, and function of these chemical synapses, which we examined in lyriform slit sense organ VS-3 of the spider Cupiennius salei. The cuticular slits of
Bo Hjorth Bentzen et al.
Advances in pharmacological sciences, 2011, 578273-578273 (2011-12-14)
Intuitively one might expect that activation of GABAergic inhibitory neurons results in bradycardia. In conscious animals the opposite effect is however observed. GABAergic neurons in nucleus ambiguus hold the ability to control the activity of the parasympathetic vagus nerve that

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