Merck
所有图片(2)

A5474

SAFC

L-天冬氨酸

别名:
(S)-氨基丁二酸, (S)-(+)-氨基琥珀酸
线性分子式:
HO2CCH2CH(NH2)CO2H
CAS号:
分子量:
133.10
Beilstein:
1723530
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.26

质量水平

400

生物来源

non-animal source

测定

≥98.5%

形式

crystalline powder

manufacturer/tradename

Ajinomoto

technique(s)

cell culture | mammalian: suitable

杂质

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

>300 °C (dec.) (lit.)

溶解性

1 M HCl: 50 mg/mL

适用性

suitable for manufacturing use

application(s)

pharmaceutical (small molecule)

异质活性

cytotoxicity, tested

SMILES string

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Gene Information

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应用

L-天冬氨酸是23种蛋白质氨基酸之一。 它是一种非必需氨基酸。 它作为细胞培养基成分被用于治疗性重组蛋白和单克隆抗体的商业化生物制造。

生化/生理作用

快速突触兴奋的主要神经递质。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书

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原产地证书 (CofO)

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Guus B Erkens et al.
Nature, 502(7469), 119-123 (2013-10-05)
Excitatory amino acid transporters (EAATs) are secondary transport proteins that mediate the uptake of glutamate and other amino acids. EAATs fulfil an important role in neuronal signal transmission by clearing the excitatory neurotransmitters from the synaptic cleft after depolarization of
Ann-Louise Johansson et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8912-8917 (2013-05-16)
Proton transfer across biological membranes underpins central processes in biological systems, such as energy conservation and transport of ions and molecules. In the membrane proteins involved in these processes, proton transfer takes place through specific pathways connecting the two sides
Tamami Uejima et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 3), 345-351 (2013-03-23)
Rab small GTPases regulate vesicle transport in eukaryotes by interacting with various effectors. Guanine nucleotide-exchange factor (GEF) catalyzes the transition from inactive GDP-bound Rab to active GTP-bound Rab. The existence of several GDP-bound intermediates containing the Arabidopsis thaliana Rab5 homologue
Manuel Neeb et al.
Journal of medicinal chemistry, 57(13), 5554-5565 (2014-06-24)
Drug molecules should remain uncharged while traveling through the body and crossing membranes and should only adopt charged state upon protein binding, particularly if charge-assisted interactions can be established in deeply buried binding pockets. Such strategy requires careful pKa design
Yoshikatsu Kanai et al.
Molecular aspects of medicine, 34(2-3), 108-120 (2013-03-20)
Glutamate transporters play important roles in the termination of excitatory neurotransmission and in providing cells throughout the body with glutamate for metabolic purposes. The high-affinity glutamate transporters EAAC1 (SLC1A1), GLT1 (SLC1A2), GLAST (SLC1A3), EAAT4 (SLC1A6), and EAAT5 (SLC1A7) mediate the

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