Merck
所有图片(6)

文件

A8626

Sigma-Aldrich

腺嘌呤

≥99%

所有图片(6)
别名:
6-氨基嘌呤, 维生素 B4
Empirical Formula (Hill Notation):
C5H5N5
CAS号:
73-24-5
分子量:
135.13
Beilstein:
5777
EC 号:
200-796-1
MDL编号:
MFCD00041790
PubChem化学物质编号:
24891349
NACRES:
NA.51

生物来源

synthetic

质量水平

200

检测方案

≥99%

形式

powder

technique(s)

UV/Vis spectroscopy: suitable

颜色

white to off-white

mp

>360 °C (lit.)

溶解性

0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan

储存温度

room temp

SMILES string

Nc1ncnc2[nH]cnc12

InChI

1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

InChI key

GFFGJBXGBJISGV-UHFFFAOYSA-N

Gene Information

human ... AKT1(207) , GSK3B(2932) , LCK(3932) , MAP3K1(4214) , MAPK14(1432) , MAPK8(5599) , MAPK9(5601) , MAPKAPK2(9261) , PRKACA(5566) , PRKCA(5578) , RAF1(5894) , ROCK2(9475)
mouse ... Mapk1(26413)
rat ... Camk2a(25400) , Mapk10(25272)

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此商品
A2786A5665A0230000
Adenine ≥99%

Sigma-Aldrich

A8626

腺嘌呤

Adenine BioReagent, suitable for cell culture

Sigma-Aldrich

A2786

腺嘌呤

Adenine BioReagent, suitable for plant cell culture, ≥99%

Sigma-Aldrich

A5665

腺嘌呤

Adenine European Pharmacopoeia (EP) Reference Standard

A0230000

腺嘌呤

assay

≥99%

assay

≥99%

assay

≥99%

assay

-

form

powder

form

powder

form

powder

form

solid

color

white to off-white

color

white to off-white

color

white to off-white

color

-

mp

>360 °C (lit.)

mp

>360 °C (lit.)

mp

>360 °C (lit.)

mp

>360 °C (lit.)

solubility

0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

-

一般描述

腺嘌呤是一种嘌呤核碱基。它是DNA和RNA的一部分。腺嘌呤也是辅因子（NAD、FAD）和信号分子（cAMP）的组成部分

应用

腺嘌呤可用于：
  • 作为缺硼培养基的一种成分来生产酵母，以评估酵母是否受到硼的刺激
  • 作为成年大鼠的食物补充剂，研究饮食中腺嘌呤超负荷的影响
  • 作为基础培养基的核酸碱基补充剂，用于莫来芽孢杆菌和枯草芽孢杆菌的生长，研究表明，这些细菌的厌氧性生长需要DNA或脱氧核糖核苷
  • 作为添加剂来研究腺嘌呤对分批培养非泌乳荷斯坦奶牛瘤胃中CH4产生和发酵的影响
  • 在一项研究中用于大鼠腺嘌呤饮食，以发现腺嘌呤诱发的慢性肾脏病（CKD）早期阶段的血液标志物

生化/生理作用

腺嘌呤在多种体内 和 体外生化过程中起着重要作用。腺嘌呤通过核糖转化为腺苷。磷酸化后，会形成AMP、ADP和ATP。ATP是细胞的能量货币，在细胞代谢过程中是必需的。腺嘌呤代谢为2,8-二羟基腺嘌呤，如果在老鼠的近端小管中积聚，会诱发严重贫血、慢性肾脏疾病（CKD）。基于腺嘌呤的衍生物会引发针对dsDNA病毒的抗病毒功能，可被用于生成抗病毒支架。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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腺嘌呤 单盐酸盐

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The prebiotic role of adenine: a critical analysis
Shapiro R
Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life, 25(1-3), 83-98 (1995)
A novel approach to adenine-induced chronic kidney disease associated anemia in rodents
Rahman A, et al.
PLoS ONE, 13(2), e0192531-e0192531 (2018)
Cristiene Okabe et al.
American journal of physiology. Renal physiology, 305(2), F155-F163 (2013-05-10)
Adenine overload promotes intratubular crystal precipitation and interstitial nephritis. We showed recently that these abnormalities are strongly attenuated in mice knockout for Toll-like receptors-2, -4, MyD88, ASC, or caspase-1. We now investigated whether NF-κB activation also plays a pathogenic role
E M Ungerfeld et al.
Canadian journal of microbiology, 49(10), 650-654 (2003-12-10)
The inhibition of pyruvate oxidative decarboxylation as a means of decreasing ruminal methanogenesis in vitro was studied. In the first experiment, the addition of adenosine and adenine (with and without ribose) to ruminal batch cultures did not decrease methanogenesis. In
Toshihiro Kobayashi et al.
Analytical and bioanalytical chemistry, 406(5), 1365-1376 (2013-11-16)
To identify blood markers for early stages of chronic kidney disease (CKD), blood samples were collected from rats with adenine-induced CKD over 28 days. Plasma samples were subjected to metabolomic profiling by liquid chromatography-mass spectrometry, followed by multivariate analyses. In
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