Merck
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C4859

Sigma-Aldrich

放线菌酮 溶液

Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture

Synonym(s):
CHX
Empirical Formula (Hill Notation):
C15H23NO4
CAS Number:
Molecular Weight:
281.35
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

生物来源

microbial

质量水平

300

描述

suitable for testing specifications (CHO C. growth inhibitor)

形式

solution

浓度

100 mg/mL in DMSO

溶解性

DMSO: soluble

抗生素抗菌谱

fungi
yeast

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES string

O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

Gene Information

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特异性

经测试可用于细胞生长停滞、选择抗环己酰亚胺的酵母、诱导凋亡、以及促进通过FasL凋亡的诱导。

包装

1 mL in glass bottle

生化/生理作用

环己酰亚胺(CHX)是由灰链霉菌产生的一种抗生素。它的主要生物学活性是真核生物中的翻译抑制,从而导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。

其他说明

保存于密闭容器内,置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。储存类别(TRGS 510): 不可燃,急性毒性1和2类/剧毒有害物质。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(F)

188.6 °F - closed cup

闪点(C)

87 °C - closed cup

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Certificate of Origin

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