Merck
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文件

D6134

Sigma-Aldrich

D-2-脱氧葡萄糖

≥99% (GC), crystalline

所有图片(5)
别名:
2-脱氧-D-葡糖
Empirical Formula (Hill Notation):
C6H12O5
CAS号:
154-17-6
分子量:
164.16
Beilstein:
1723331
EC 号:
205-823-0
MDL编号:
MFCD00151328
PubChem化学物质编号:
24894000
NACRES:
NA.25

生物来源

synthetic (organic)

检测方案

≥99% (GC)

形式

crystalline

technique(s)

gas chromatography (GC): suitable

颜色

white

mp

146-147 °C (lit.)

溶解性

H2O: soluble 330 mg/mL, clear, colorless

储存温度

2-8°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)CC=O

InChI

1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1

InChI key

VRYALKFFQXWPIH-PBXRRBTRSA-N

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D8375D3179731978
2-Deoxy-D-glucose ≥99% (GC), crystalline

Sigma-Aldrich

D6134

D-2-脱氧葡萄糖

2-Deoxy-D-glucose ≥98% (GC), crystalline

Sigma-Aldrich

D8375

D-2-脱氧葡萄糖

2-Deoxy-D-glucose BioXtra, ≥98%

Sigma-Aldrich

D3179

D-2-脱氧葡萄糖

2-Deoxy-D-glucose-1-13C 99 atom % 13C, 98% (CP)

Sigma-Aldrich

731978

2-Deoxy-D-glucose-1-13C

assay

≥99% (GC)

assay

≥98% (GC)

assay

≥98%

assay

98% (CP)

form

crystalline

form

crystalline

form

powder

form

solid

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

-

color

white

color

white to off-white

color

-

color

-

mp

146-147 °C (lit.)

mp

146-147 °C (lit.)

mp

146-147 °C (lit.)

mp

-

应用

2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

生化/生理作用

2-脱氧-D-葡萄糖（2-脱氧葡萄糖）是一种葡萄糖类似物，可通过作用于己糖激酶这一糖酵解限速步骤来抑制糖酵解。 它会被己糖激酶磷酸化为不能被磷酸葡萄糖异构酶进一步代谢的2-DG-P。 这将导致2-DG-P在细胞中的集聚以及细胞ATP的缺失。在体外，2-脱氧葡萄糖已显示出可诱导自噬、提高ROS的产生并激活AMPK。

制备说明

A further purification of the Grade II material by recrystallization.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8790-8794 (2013-05-15)
Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In this study, we demonstrate that, with the microarrays for mass spectrometry platform, we are able to observe this variability. We monitor environmentally (2-deoxy-D-glucose)
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Newly synthesized membrane proteins are constantly sorted from the endoplasmic reticulum (ER) to various membranous compartments. How proteins specifically enrich at the inner nuclear membrane (INM) is not well understood. We have established a visual in vitro assay to measure
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Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by bilateral renal cyst formation. Recent identification of signaling cascades deregulated in ADPKD has led to the initiation of several clinical trials, but an approved therapy is still
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