F6879

Sigma-Aldrich

铁蛋白 来源于人类脾脏

Type V, 10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide

CAS号:
MDL编号:
NACRES:
NA.61

生物来源

human spleen

质量水平

100

无菌性

sterile-filtered

类型

Type V

形式

liquid

包装

vial of 2 μg

浓度

10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide

UniProt登记号

储存温度

2-8°C

Gene Information

应用

Ferritin is an iron storage protein that plays a central role in iron metabolism, and may be elevated in inflammatory or malignant diseases. It has been used in studies as an indicator of body iron supply, but may prove inaccurate in in the presence of chronic inflammation.

生化/生理作用

A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Flavia G N Rosado et al.
American journal of clinical pathology, 139(6), 713-727 (2013-05-22)
Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed disease involving a final common pathway of hypercytokinemia, which can result in end-organ damage and death. Although an early diagnosis is crucial to decrease mortality, the definitive diagnosis is often...
Rachel Collings et al.
The American journal of clinical nutrition, 98(1), 65-81 (2013-05-31)
Absorption factors are required to convert physiologic requirements for iron into Dietary Reference Values, but the absorption from single meals cannot be used to estimate dietary iron absorption. The objective was to conduct a systematic review of iron absorption from...
Ann Kruger et al.
Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 40(2), 135-139 (2013-06-19)
This study examined whether a change infrequency of administration of erythropoietin-stimulating agent affected hemoglobin levels in patients on peritoneal dialysis. Data were extracted from the Australian Renal Anaemia Management database for the years 2002 and 2008. Less frequent dosing and...
Edward Pelle et al.
Journal of cosmetic science, 64(3), 175-179 (2013-06-12)
Menstruation and desquamation are important routes for humans to excrete iron. Because menstruation is no longer available in postmenopausal women, in the present study, we examined whether iron accumulates more in postmenopausal skin than in premenopausal skin. Skin biopsy samples...
Opposite extremes in hepcidin status between the US and Japan.
Takeshi Nakanishi et al.
The American journal of medicine, 126(5), e11-e11 (2013-04-16)

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门