Merck
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G8415

Sigma-Aldrich

L-谷氨酸

from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%

Synonym(s):
(S)-2-氨基戊二酸, Glu
Linear Formula:
HO2CCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
147.13
Beilstein:
1723801
EC 号:
MDL编号:
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

质量水平

200

生物来源

non-animal source

Agency

meets EP testing specifications

测定

98.5-100.5%

形式

powder

technique(s)

cell culture | mammalian: suitable

杂质

endotoxin, tested

颜色

white

mp

205 °C (dec.) (lit.)

溶解性

1 M HCl: 100 mg/mL

密度

1.54 g/cm3 at 20 °C

痕量阴离子

chloride (Cl-): ≤200 ppm
sulfate (SO42-): ≤200 ppm

痕量阳离子

As: ≤1 ppm, passes test
Fe: ≤10 ppm, passes test
NH4+: ≤200 ppm, passes test

application(s)

pharmaceutical (small molecule)

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

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应用

L-谷氨酸已被用作细胞培养基的补充剂,用于培养海马神经元和试用hT-PA(人组织纤溶酶原激活物)获得的细胞系。

包装

100 g in poly bottle
10 mg in glass bottle
1 kg in poly bottle

生化/生理作用

谷氨酸或谷氨酸盐可用作神经递质,还可作为其他神经递质(如γ-氨基丁酸)的前体。谷氨酸在控制生长、繁殖、维持和免疫的许多代谢途径中也发挥着关键作用。它被转化为α-酮戊二酸,是TCA(三羧酸)循环的关键组分,也是核酸和某些氨基酸生物合成的前体。在细胞中,谷氨酰胺酶将谷氨酰胺转化为谷氨酸盐。谷氨酰胺是淋巴细胞、肠细胞、巨噬细胞和肿瘤等细胞快速分裂的能量来源。谷氨酰胺通过细胞mTOR(雷帕霉素的哺乳动物靶标)信号传导通路介导蛋白质周转。它还与细胞凋亡抑制有关。
一种兴奋性氨基酸神经递质,为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Articles

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Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

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Glutamine Metabolism is Dysregulated in Many Cancer Cells

This is an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

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