Merck

G8634

Sigma-Aldrich

鸟苷5′-γ-硫代三磷酸 四锂盐 四锂盐

≥90% (contains < 10% GDP, HPLC), powder

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别名:
GTP & # 947;S 四锂盐, GTP-γ-S-Li4, 鸟苷5 & # 8242;-O-(3-硫代三磷酸) 四锂盐
经验公式(希尔记法):
C10H12Li4N5O13P3S
CAS号:
分子量:
562.98
Beilstein:
8182249
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥90% (contains < 10% GDP, HPLC)

形式

powder

颜色

white to off-white

溶解性

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

运输

dry ice

储存温度

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

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G7637G5884G6129
vibrant-m

G6129

鸟苷-3′,5′-环一磷酸 钠盐

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥90% (contains < 10% GDP, HPLC)

assay

≥85% (HPLC)

assay

~95% (HPLC)

assay

≥99% (HPLC)

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

-

solubility

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

solubility

H2O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

solubility

H2O: 100 mg/mL

solubility

H2O: 50 mg/mL

color

white to off-white

color

white

color

white

color

white

应用

鸟苷 5′-[γ-硫代]三磷酸四锂盐可用于:
  • 作为裂解缓冲液的组成部分
  • 用于卵母细胞和哺乳动物细胞的膜片钳实验中,保持G蛋白的持续活跃状态
  • 与G蛋白α偶联,研究其对激酶活性的作用

生化/生理作用

GTP-& # 947;-S是一种不可水解的GTP类似物,以其作为G蛋白活化剂的作用而闻名。最近研究已经证明它在体外保护蛋白质免受蛋白水解降解,以酪氨酸激酶依赖的方式刺激葡萄糖转运蛋白4易位,刺激磷脂酶和诱导肌动蛋白聚合

特点和优势

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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