Merck

H9377

Sigma-Aldrich

次黄嘌呤

≥99.0%

别名:
6-羟基嘌呤
Empirical Formula (Hill Notation):
C5H4N4O
CAS号:
分子量:
136.11
Beilstein:
5811
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.51

生物来源

synthetic (organic)

质量水平

检测方案

≥99.0%

形式

powder

mp

>300 °C (lit.)

溶解性

formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow

SMILES string

O=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChI key

FDGQSTZJBFJUBT-UHFFFAOYSA-N

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此商品
H9636A4660X4002
Hypoxanthine ≥99.0%

Sigma-Aldrich

H9377

次黄嘌呤

Hypoxanthine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

H9636

次黄嘌呤

6-Thioguanine Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Sigma-Aldrich

A4660

6-硫代鸟嘌呤

Xanthine BioUltra, ≥99%

Sigma-Aldrich

X4002

黄嘌呤

assay

≥99.0%

assay

≥99%

assay

~98%

assay

≥99%

form

powder

form

powder

form

lyophilized powder

form

powder

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

≥300 °C (lit.)

mp

-

solubility

formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow

solubility

formic acid: water (2:1): 50 mg/mL

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy

solubility

1 M NaOH: 0.1 M, clear, colorless to light yellow

Quality Level

300

Quality Level

-

Quality Level

200

Quality Level

-

应用

次黄嘌呤是一种营养添加剂,适用于细菌、寄生虫(恶性疟原虫)和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。
次黄嘌呤已被用于:
  • 在氧嗪酸钾(PO)诱导的小鼠高尿酸血症模型中,灌胃并评估体内巴氏全脂牛奶中黄嘌呤氧化酶(XO)的活性
  • 作为Iscove改良的DMEM培养基(IMDM)的补充剂,用于培养体外细胞株(EL-1细胞)
  • 作为高效液相色谱-紫外法(HPLC-UV)的纯标准品,用于定量分析玻璃体液样本中的次黄嘌呤以推断死亡时间

生化/生理作用

次黄嘌呤(Hypoxanthine)是嘌呤代谢的中间产物。它在一些转运RNA(tRNA)中作为反密码子′-碱基发挥重要作用。结构虽然与鸟嘌呤(Gua)类似,但C(2)位没有环外氨基。它可作为底物,用于次黄嘌呤-鸟嘌呤磷酸核糖转移酶的特异性和动力学研究。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Sigma-Aldrich

T1895

胸苷

Xanthine BioUltra, ≥99%

Sigma-Aldrich

X4002

黄嘌呤

Didanosine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000441

去羟肌苷杂质A

Didanosine Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1191226

次黄嘌呤

Dhaksshaginy Rajalingam et al.
International archives of occupational and environmental health, 94(8), 1905-1915 (2021-06-03)
Several studies show that severe social stressors, e.g., in the form of exposure to workplace bullying in humans, is associated with negative mental health effects such as depression and anxiety among those targeted. However, the understanding of the underlying biological
Different processed milk with residual xanthine oxidase activity and risk of increasing serum uric acid level
Sha W, et al.
Food Bioscience (2021)
Influence of the nature of death in biochemical analysis of the vitreous humour for the estimation of post-mortem interval
Perez-Martinez C, et al.
Australian journal of public health (2020)
Ultrafast electronic deactivation dynamics of the rare natural nucleobase hypoxanthine
Rottger K, et al.
Chemical Physics Letters (2012)
Javier Acosta et al.
Frontiers in bioengineering and biotechnology, 8, 677-677 (2020-07-17)
In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase (HGPRT)/adenylate kinase (AMPK) from Zobellia galactanivorans (ZgHGPRT/AMPK). In this respect, we report for the first time

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Uric Acid in Cell Culture

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HPLC Analysis of Xanthines on Purospher® STAR RP-18 endcapped

Xanthine is a purine base found in most human body tissues and fluids as well as in other organisms. Methylated xanthines (methylxanthines), which include caffeine, paraxanthine, theobromine, and theophylline, commonly used for their effects as mild stiµlants and as bronchodilators, notably in the treatment of asthma symptoms. This application shows the efficient separation of several common xanthines and may be applied their analysis in any number of desired matrices.

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