Merck
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文件

H9636

Sigma-Aldrich

次黄嘌呤

powder, BioReagent, suitable for cell culture

所有图片(4)
别名:
6-羟基嘌呤
Empirical Formula (Hill Notation):
C5H4N4O
CAS号:
68-94-0
分子量:
136.11
Beilstein:
5811
EC 号:
200-697-3
MDL编号:
MFCD00005725
PubChem化学物质编号:
24895864
NACRES:
NA.75

产品线

BioReagent

检测方案

≥99%

形式

powder

technique(s)

cell culture | mammalian: suitable

mp

>300 °C (lit.)

溶解性

formic acid: water (2:1): 50 mg/mL

SMILES string

O=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChI key

FDGQSTZJBFJUBT-UHFFFAOYSA-N

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此商品
H93771191226Y0000441
Hypoxanthine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

H9636

次黄嘌呤

Hypoxanthine ≥99.0%

Sigma-Aldrich

H9377

次黄嘌呤

Didanosine Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1191226

次黄嘌呤

Didanosine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000441

去羟肌苷杂质A

assay

≥99%

assay

≥99.0%

assay

-

assay

-

form

powder

form

powder

form

-

form

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

solubility

formic acid: water (2:1): 50 mg/mL

solubility

formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow

solubility

-

solubility

-

一般描述

次黄嘌呤(6-羟嘌呤)，一种嘌呤衍生物，是天然化合物。它是腺嘌呤的脱氨基形式，也是一磷酸腺苷(AMP)的分解产物。

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫（恶性疟原虫）和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。
次黄嘌呤已被用于：
  • 作为HEPES (4-(2-羟乙基)-1-哌嗪乙烷磺酸) -buffered Roswell park memorial institute (RPMI)补充剂，培养镰状疟原虫菌株IT/FCR3
  • 制备Dulbecco′改性′s培养基 (DMEM) + MXH，用于选择嵌合修饰痘苗病毒安卡拉株(MVA)
  • 产生超氧阴离子
  • 用于制备杂交瘤选择和维持培养基。

生化/生理作用

次黄嘌呤能够刺激细胞死亡。它也能诱导活性氧(ROS)。通过氧化应激刺激细胞凋亡可导致内皮功能障碍。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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偶氮丝氨酸-次黄嘌呤 (50×)

Construction of FWPV Chimaeric MVA
Buttigieg KR, et al.
Bio-protocol, 5(1), 1-11 (2019)
Biochemical Methods of Estimating the Time Since Death
Human Body Decomposition, 53-90 (2016)
Hypoxanthine causes endothelial dysfunction through oxidative stress-induced apoptosis
Kim YJ, et al.
Biochemical and biophysical research communications, 482(4), 821-827 (2017)
Binding of Plasmodium falciparum to CD36 can be shielded by the glycocalyx
Hempel C, et al.
Malaria Journal, 16(1), 1-11 (2017)
Diana Tamayo et al.
PLoS neglected tropical diseases, 10(3), e0004481-e0004481 (2016-03-11)
The ability of Paracoccidioides to defend itself against reactive oxygen species (ROS) produced by host effector cells is a prerequisite to survive. To counteract these radicals, Paracoccidioides expresses, among different antioxidant enzymes, superoxide dismutases (SODs). In this study, we identified
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