Merck
All Photos(4)

K1377

Sigma-Aldrich

卡那霉素 硫酸酯 来源于卡那霉素链霉菌

powder, BioReagent, suitable for cell culture, suitable for plant cell culture

Synonym(s):
卡那霉素 A, 卡那霉素碱 硫酸盐
Empirical Formula (Hill Notation):
C18H36N4O11 · H2O4S
CAS Number:
Molecular Weight:
582.58
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.76

生物来源

Streptomyces kanamyceticus

质量水平

200

产品线

BioReagent

形式

powder

效能

≥750 μg per mg (dry basis)

technique(s)

cell culture | mammalian: suitable
cell culture | plant: suitable

杂质

≤5% kanamycin B

颜色

white to off-white

溶解性

H2O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

application(s)

agriculture

作用机制

protein synthesis | interferes

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

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一般描述

在生物技术中用于抑制蛋白质合成。建议以 100mg/L 的量用于细胞培养应用。
Chemical structure: aminoglycoside

应用

Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media.

包装

1, 5, 25 g in poly bottle

生化/生理作用

作用机制:该产品通过与70S核糖体亚基结合,抑制易位并引起错误编码而起作用。

耐药机制:氨基糖苷类修饰酶(包括乙酰转移酶、磷酸转移酶、核苷酸转移酶)可以改变这种抗生素,阻止其与核糖体相互作用。

抗菌谱:硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

注意

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

制备说明

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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Product Information Sheet

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