Merck
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L5163

Sigma-Aldrich

红海海绵素A

from sea sponge, ≥85% (HPLC), waxy solid

Synonym(s):
LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-羟基-5,12-二甲基-3-氧代-2,16-二氧杂双环[13.3.1]十九碳-4,8,10-三烯-17-基)-2-噻唑烷酮
Empirical Formula (Hill Notation):
C22H31NO5S
CAS Number:
Molecular Weight:
421.55
PubChem化学物质编号:
NACRES:
NA.77

生物来源

sea sponge

质量水平

200

测定

≥85% (HPLC)

形式

waxy solid

分子量

421.6

溶解性

DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES string

C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CC\C=C\C=C1

InChI

1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1

InChI key

DDVBPZROPPMBLW-IZGXTMSKSA-N

一般描述

红海海绵素A是一种从红海海绵 Latrunculia magnifica中分离得到的毒素。它在 体外 参与纯肌动蛋白聚合的形态学改变。它通过与肌动蛋白的核苷酸裂缝结合而形成复合物,使肌动蛋白纤维伸长。

应用

红海海绵素A已被用作A549细胞的培养基补充剂,确定了A549人肺癌细胞中CAV9的内化机制。

生化/生理作用

红海海绵素A通过不同于细胞松弛素的机制抑制肌动蛋白聚合。红海海绵素A破坏了微丝介导的过程。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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