L8000

Sigma-Aldrich

L-亮氨酸

reagent grade, ≥98% (HPLC)

别名:
(S)-2-氨基-4-甲基戊酸
线性分子式:
(CH3)2CHCH2CH(NH2)CO2H
CAS号:
分子量:
131.17
Beilstein/REAXYS Number:
1721722
EC 号:
MDL编号:
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

质量水平

200

等级

reagent grade

测定

≥98% (HPLC)

形式

powder

应用

ligand binding assay: suitable
peptide synthesis: suitable

杂质

isoleucine and methionine, essentially free

颜色

white to off-white

mp

>300 °C (lit.)

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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应用

L-亮氨酸已被用作雷帕霉素(mTOR)机制靶标的激动剂,以确定AMPK/mTOR途径是否参与小檗碱介导的J774A.1细胞自噬。它也被用于转化后细胞的选择。

包装

25, 50, 100, 250 g in poly bottle
1 kg in poly bottle

生化/生理作用

亮氨酸是一种非生糖必需氨基酸。它是一种支链氨基酸,是蛋白质的结构组分。亮氨酸对胰岛素的释放可产生积极影响,从而消除血液中的毒性糖。亮氨酸的降解会导致酮体的形成。

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

原产地证书 (CofO)

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
Xiaodi Fan
Journal of Translational Medicine (2015)
Dr. Victor Prisk
The Leucine Factor Diet: The Scientifically-Proven Approach to Combat Sugar, Burn Fat and Build Muscle (2015)
Paula K N Alves et al.
Cells, 9(12) (2020-12-06)
In this study we surveyed a rat skeletal muscle RNA-Seq for genes that are induced by hindlimb immobilization and, in turn, become attenuated by leucine supplementation. This approach, in search of leucine-atrophy protection mediating genes, identified histone deacetylase 4 (HDAC4)...
Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra m
Bio-protocol (2017)
Susan A Masino
Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2016)

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