Merck

N8523

Sigma-Aldrich

Monoclonal Anti-NF-κB antibody produced in mouse

clone NF-12, ascites fluid

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别名:
Anti-CVID12, Anti-EBP-1, Anti-KBF1, Anti-NF-kB, Anti-NF-kB1, Anti-NF-kappa-B1, Anti-NF-kappaB, Anti-NF-kappabeta, Anti-NFKB-p105, Anti-NFKB-p50, Anti-NFkappaB
MDL编号:
NACRES:
NA.41

生物来源

mouse

偶联物

unconjugated

抗体形式

ascites fluid

antibody product type

primary antibodies

克隆

NF-12, monoclonal

分子量

antigen 65 kDa

包含

15 mM sodium azide

species reactivity

human, mouse

technique(s)

immunocytochemistry: suitable
microarray: suitable
western blot: 1:1,000 using a whole cell extract from a mouse fibroblast cell line

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... NFKB1(4790)
mouse ... Nfkb1(18033)

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此商品
WH0004790M1SAB4502609SAB4502610
Anti-NF-κB p65 antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4502609

抗-NF-κB p65 兔抗

Anti-NF-κB p65 antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4502610

抗-NF-κB p65 兔抗

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

NF-12, monoclonal

clone

2E6, monoclonal

clone

polyclonal

clone

polyclonal

mol wt

antigen 65 kDa

mol wt

-

mol wt

antigen 60 kDa

mol wt

antigen 60 kDa

species reactivity

human, mouse

species reactivity

human

species reactivity

human, mouse

species reactivity

rat, mouse, human

一般描述

Monoclonal Anti-NF-κB p65 (mouse IgG1 isotype) is derived from the NF-12 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with a recombinant, mouse NF-κB p65 fragment. Nuclear factor κB (NF-κB1) is a member of NF-κB/Rel family of transcription factors.
Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (NFKB1) is a subunit of nuclear factor κB (NF-κB) and exists as a dimer. It is expressed in the cytosol.

免疫原

recombinant mouse NF-κB p65 fragment (C-terminal, 151 amino acids).

应用

Monoclonal Anti-NF-κB antibody produced in mouse has been used in immunohistochemistry and Western blotting.

生化/生理作用

Nuclear factor kappa-B (NF-κB1) has an ability to affect transcription of κB reporter genes positively or negatively when assayed following transfection.
Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (NFKB1) has a role in hippocampal neurogenesis. It regulates the signaling by nuclear factor κB (NF-κB). Deletion of the gene in mice leads to defects in innate and adaptive immunity. The protein acts as a mediator of apoptotic response to S-phase DNA damage and replication stress. NFKB1 modulates the structural plasticity of cortical neurons. Knockout of the protein in mice has been shown to cause liver apoptosis and embryonic death.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(F)

Not applicable

闪点(C)

Not applicable


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其他客户在看

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NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions
Caamano J and Hunter C A
Clinical Microbiology Reviews, 15(3), 414-429 (2002)
Deletion of nuclear factor-?B p50 upregulates fatty acid utilization and contributes to an anti-obesity and high-endurance phenotype in mice.
Minegishi Y
American Journal of Physiology. Endocrinology and Metabolism, 309(6), E523-E533 (2015)
Loss of Nfkb1 leads to early onset aging
Giovanna M. Bernal
Aging, 6(11), 931?942-931?942 (2014)
A Combination of Podophyllotoxin and Rutin Attenuates Radiation Induced Gastrointestinal Injury by Negatively Regulating NF-?B/p53 Signaling in Lethally Irradiated Mice
Bhargab Kalita
PLoS ONE, 11(12), e0168525-e0168525 (2016)
Cell autonomous and noncell-autonomous role of NF-?B p50 in astrocyte-mediated fate specification of adult neural progenitor cells.
Cvijetic S
Glia, 65, 169-181 (2017)

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