Merck

Q4951

Sigma-Aldrich

槲皮素

≥95% (HPLC), solid

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别名:
2-(3,4-二羟苯基)-3,5,7-三羟基-4H-1-苯并吡喃-4-酮, 3,3′,4′,5,6-五羟基黄酮
Empirical Formula (Hill Notation):
C15H10O7
CAS号:
分子量:
302.24
Beilstein:
317313
EC 号:
PubChem化学物质编号:

生物来源

synthetic (organic)

质量水平

检测方案

≥95% (HPLC)

形式

solid

mp

316.5 °C

溶解性

water: practically insoluble

储存温度

room temp

SMILES string

OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1

InChI

1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

InChI key

REFJWTPEDVJJIY-UHFFFAOYSA-N

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此商品
PHR1488PHL892621592409
Quercetin ≥95% (HPLC), solid

Sigma-Aldrich

Q4951

槲皮素

Quercetin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1488

槲皮素

Quercetin phyproof® Reference Substance

PHL89262

槲皮素

Quercetin United States Pharmacopeia (USP) Reference Standard

USP

1592409

槲皮素

form

solid

form

-

form

-

form

-

solubility

water: practically insoluble

solubility

-

solubility

-

solubility

-

storage temp.

room temp

storage temp.

-10 to -25°C

storage temp.

-

storage temp.

−20°C

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

应用

  • 槲皮素是一种抗氧化剂,可逆转2型糖尿病患者高血糖和高血糖血清的免疫抑制作用。
  • 它已被用作 欧洲黑蜂的一种解毒植物化学物质。
  • 它被用作DPPH(2,2-二苯基-1-苦肼)自由基清除实验中的阳性对照。它还可用于制作总黄酮含量测定的校准曲线。

生化/生理作用

槲皮素是一种具有抗癌活性的黄酮类化合物。 槲皮素是一种线粒体ATP酶和磷酸二酯酶抑制剂。它抑制PI3激酶活性,并略抑制PIP激酶活性。槲皮素对癌细胞具有抗增殖作用,通过II型雌激素受体降低癌细胞生长,并在细胞周期G1晚期抑制人白血病T细胞。 槲皮素还可能抑制脂肪酸合酶活性。

特点和优势

该化合物收录于 受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢 》页面。要浏览其他手册页面,请单击此处
该化合物是ADME毒素和激酶磷酸酶的特色产品。点击这里 以发现更多ADME Tox激酶磷酸酶生物学 特色产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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槲皮素 二水合物

Impacts of Dietary Phytochemicals in the Presence and Absence of Pesticides on Longevity of Honey Bees (Apis mellifera).
Liao LH et al.
Insects, 8, E22-E22 (2017)
Lucia Panzella et al.
Antioxidants (Basel, Switzerland), 8(4) (2019-04-04)
Exhausted woods represent a byproduct of tannin industrial production processes and their possible exploitation as a source of antioxidant compounds has remained virtually unexplored. We herein report the characterization of the antioxidant and other properties of practical interest of exhausted
High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/?-catenin and p38 MAPK.
Gilardini Montani MS et al.
Biochimica et Biophysica Acta, 1862, 805-805 (2016)
Akari Ishisaka et al.
Archives of biochemistry and biophysics, 557, 11-17 (2014-06-04)
In recent years, many papers have suggested that dietary flavonoids may exert beneficial effects in the brain tissue for the protection of neurons against oxidative stress and inflammation. However, the bioavailability of flavonoids across the blood-brain barrier and the localization
Joanna Cunanan et al.
PloS one, 15(6), e0234375-e0234375 (2020-06-20)
Renal dysplasia, the major cause of childhood renal failure, is characterized by defective branching morphogenesis and nephrogenesis. Beta-catenin, a transcription factor and cell adhesion molecule, is markedly increased in the nucleus of kidney cells in human renal dysplasia and contributes

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